CAS: 19614-12-1; 1-Bromo-2-(Bromomethyl)-4-Methoxybenzene

上下游产品

CAS号27060-75-9 2-溴-5-甲氧基甲苯 | CAS号77-48-5 二溴海因 | CAS号150192-39-5 2-溴-5-甲氧基苯甲醇 | CAS号100-84-5 间甲基苯甲醚 | CAS号874-98-6 3-甲氧基苄溴 | CAS号7507-86-0 2-溴-5-甲氧基苯甲醛 | CAS号22921-68-2 2-溴-5-甲氧基苯甲酸 | CAS号591-31-1 3-甲氧基苯甲醛 | CAS号104174-43-8 4-(3-Methoxyphe... | CAS号19962-23-3 1-methoxy-3-phe... | CAS号74-96-4 溴乙烷 | CAS号391957-02-1 diethyl 2-bromo... | CAS号27387-23-1 2-(2-溴-5-甲氧基苯基)乙腈 | CAS号7507-86-0 2-溴-5-甲氧基苯甲醛 | CAS号139962-95-1 2-甲酰基-4-甲氧基苯硼酸 | CAS号138642-47-4 2-溴-5-甲氧基苯甲腈 | CAS号150192-39-5 2-溴-5-甲氧基苯甲醇 | CAS号120455-03-0 5-甲氧基-2-苯基-2H-吲唑

📜间甲基苯甲醚置于n-溴代丁二酰亚胺(Nbs),偶氮二异丁腈体系中,用 四氯化碳 用作溶剂,化学反应生成2-溴-5-甲氧基溴苄
参考文献:Synthesis Of Benzo-And Naphtho-Fused Bicyclo[n.3.1]Alkane Frameworks With A Bridgehead Nitrogen Function By Palladium-Catalyzed Intramolecular α'-Arylation Of α-Nitroketones
标题:Synthesis Of Benzo-And Naphtho-Fused Bicyclo[n.3.1]Alkane Frameworks With A Bridgehead Nitrogen Function By Palladium-Catalyzed Intramolecular α'-Arylation Of α-Nitroketones
摘要:环状α-硝基酮与α-卤苄卤化物在dbu存在下进行c-烷基化反应,再经pd催化的分子内c-芳基化反应,成功合成了苯并和萘并融合的双环[n.3.1]烷烃衍生物(n = 3,4,5),在这两步反应中得到了非常好的整体产率.在某些以α-硝基环辛酮为起始材料的反应中,主要产物为融合的吲哚衍生物,源于中间pd物种对羰基的分子内攻击,随后发生消除反应.
Doi:10.1039/c0Ob00526F

专利信息

专利号:US-7189864-B2
优先权日:1990-11-19
标 题:Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:US-6022996-A
优先权日:1990-11-19
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:EP-0641333-B1
优先权日:1992-05-20
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO; MONSANTO CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide compound of formula (I) from a chiral alpha amino aldehyde and halomethyllithium as an organometallic methylene-adding reagent. In formula (I) R<1> is selected from alkyl, aryl, cycloalkyl, cycloalkylalkyl and arylalkyl, which are optionally substituted with a group selected from alkyl, halogen, NO2, OR<9> or SR<9>, where R<9> represents hydrogen or alkyl; and P<1> and P<2> independently are selected from amine protecting groups, including but not limited to, arylalkyl, substituted arylalkyl, cycloalkenylalkyl and substituted cycloalkenylalkyl, allyl, substituted allyl, acyl, alkoxycarbonyl, aralkoxycarbonyl and silyl.

专利号:EP-0855388-B1
优先权日:1993-11-23
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P; FRESKOS JOHN J; DECRESCENZO GARY A; BERTENSHAW DEBORAH E; HEINTZ ROBERT M; ZHANG SUHONG; LIU CHIN; LANEMAN SCOTT A
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a cyanohydrin from a chiral alpha amino aldehyde.

专利号:US-6172235-B1
优先权日:1996-08-09
标题 :Asymmetric conjugate addition reaction
发明人：DOLLING ULF H; FREY LISA F; TILLYER RICHARD D; TSCHAEN DAVID M
权利人:MERCK & CO INC
摘要:This invention relates to a key intermediate in the synthesis of an endothelin antagonist and the synthesis of this key intermediate using an asymmetric conjugate addition reaction.

专利号:US-6353110-B1
优先权日:1997-08-08
标 题:Asymmetric conjugate addition reaction
发明人：DEVINE PAUL N; TILLYER RICHARD D; HEID JR RICHARD M; TSCHAEN DAVID M
权利人:MERCK & CO INC
摘要:This invention relates to a key intermediate in the synthesis of an endothelin antagonist the synthesis of this key intermediate via an asymmetric conjugate addition reaction.