📜4-Pyridiniummethylisothiouronium Chloride Hydrochloride置于水,Sodium Hydroxide,盐酸体系中,用 水 用作溶剂,化学反应 0.5H,以47%的收率获得4-吡啶甲硫醇 参考文献: Carbacephem ß-Lactam Antibiotics[fr] Antibiotiques De Type-Lactame à Base De Carbacéphème 标题: Carbacephem ß-Lactam Antibiotics[fr] Antibiotiques De Type-Lactame à Base De Carbacéphème
专利号:US-4500535-A 优先权日:1979-10-15 标 题:Method of regulating the immune response with pyridine derivatives 发明人:LOMBARDINO JOSEPH G; HARBERT CHARLES A 权利人:PFIZER 摘要:A series of 4-(2-carboxymethylthiomethyl)pyridines and related compounds, and their pharmaceutically acceptable salts, are disclosed as having immunoregulatory activity. Preferred compounds include 4-(2-carboxymethylthiomethyl)pyridine [alternatively named 2-(4-picolylthio)acetic acid] and (C 1 -C 4 )alkyl esters thereof, and 4-(1-formylmethylthiomethyl)-pyridine [alternatively named 2-(4-picolylthio)acetaldehyde] and bis(C 1 -C 4 )alkyl or cyclic acetals thereof. These acids, esters, aldehydes and acetals also have utility as intermediates in the synthesis of the corresponding 4-(2-hydroxyethylthiomethyl)pyridines.
专利号:US-4371696-A 优先权日:1980-07-14 标 题 :Certain pyridine methylthio acetaldehyde derivatives and non-cyclic and cyclic acetals thereof 发明人:LOMBARDINO JOSEPH G; HARBERT CHARLES A 权利人:PFIZER 摘要:A series of 4-(2-carboxymethylthiomethyl)pyridines and related compounds, and their pharmaceutically acceptable salts, are disclosed as having antiinflammatory and immunoregulatory activity. Preferred compounds include 4-(2-carboxymethylthiomethyl)pyridine [alternatively named 2-(4-picolylthio)acetic acid] and (C 1 -C 4 )alkyl esters thereof, and 4-(1-formylmethylthiomethyl)pyridine [alternatively named 2-(4-picolylthio)-acetaldehyde] and bis(C 1 -C 4 )alkyl or cyclic acetals thereof. These acids, esters, aldehydes and acetals also have utility as intermediates in the synthesis of the corresponding 4-(2-hydroxyethylthiomethyl)pyridines.
专利号:RU-2039050-C1 优先权日:1989-09-26 标 题:Derivatives of 1,2,4-triazole, optically inert or containing r- or s-configuration at c-2 and c-3 asymmetric centers, or their salts showing fungicide activity, and a method of their synthesis
参考文献:10.1038/s41557-023-01178-1 摘要:Dief EM, Low PJ, Díez-Pérez I, Darwish N. Advances in single-molecule junctions as tools for chemical and biochemical analysis. Nat Chem. 2023 May;15(5):600–14. doi: 10.1038/s41557-023-01178-1.