CAS: 1822-53-3; Pyridin-4-Ylmethanethiol

该化合物是一种含有硫磺的衍生物,其特征为反应性硫醇(-SH)功能组,附于一个环,该化合物是有机合成的多功能构件,特别是在准备三环化合物,金属协调用离心机和功能化材料时.其碱碱为金属离子提供了协调点,而硫醇组则通过硫醇-乙烯反应或分硫化形成,使该化合物能够形成易变的聚合或改变.该化合物由于具有双重反应性,在制药和材料化学中特别有用.建议由于硫醇组对氧化的敏感度,在惰性条件下进行适当处理.

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586-95-8 1822-51-1 135207-19-1

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CAS号1822-51-1 4-氯甲基吡啶盐酸盐 | CAS号1822-52-2 4-pyridiniummet... | CAS号10445-91-7 4-氯甲基吡啶 | CAS号586-95-8 4-吡啶甲醇 | CAS号2196-13-6 硫代异烟酰胺

合成工艺路线路线简述

    📜4-Pyridiniummethylisothiouronium Chloride Hydrochloride置于水,Sodium Hydroxide,盐酸体系中,用 水 用作溶剂,化学反应 0.5H,以47%的收率获得4-吡啶甲硫醇
    参考文献: Carbacephem ß-Lactam Antibiotics[fr] Antibiotiques De Type-Lactame à Base De Carbacéphème
    标题: Carbacephem ß-Lactam Antibiotics[fr] Antibiotiques De Type-Lactame à Base De Carbacéphème

    海关参考信息

    专利信息


    专利号:US-4500535-A
    优先权日:1979-10-15
    标 题:Method of regulating the immune response with pyridine derivatives
    发明人:LOMBARDINO JOSEPH G; HARBERT CHARLES A
    权利人:PFIZER
    摘要:A series of 4-(2-carboxymethylthiomethyl)pyridines and related compounds, and their pharmaceutically acceptable salts, are disclosed as having immunoregulatory activity. Preferred compounds include 4-(2-carboxymethylthiomethyl)pyridine [alternatively named 2-(4-picolylthio)acetic acid] and (C 1 -C 4 )alkyl esters thereof, and 4-(1-formylmethylthiomethyl)-pyridine [alternatively named 2-(4-picolylthio)acetaldehyde] and bis(C 1 -C 4 )alkyl or cyclic acetals thereof. These acids, esters, aldehydes and acetals also have utility as intermediates in the synthesis of the corresponding 4-(2-hydroxyethylthiomethyl)pyridines.

    专利号:US-4371696-A
    优先权日:1980-07-14
    标 题 :Certain pyridine methylthio acetaldehyde derivatives and non-cyclic and cyclic acetals thereof
    发明人:LOMBARDINO JOSEPH G; HARBERT CHARLES A
    权利人:PFIZER
    摘要:A series of 4-(2-carboxymethylthiomethyl)pyridines and related compounds, and their pharmaceutically acceptable salts, are disclosed as having antiinflammatory and immunoregulatory activity. Preferred compounds include 4-(2-carboxymethylthiomethyl)pyridine [alternatively named 2-(4-picolylthio)acetic acid] and (C 1 -C 4 )alkyl esters thereof, and 4-(1-formylmethylthiomethyl)pyridine [alternatively named 2-(4-picolylthio)-acetaldehyde] and bis(C 1 -C 4 )alkyl or cyclic acetals thereof. These acids, esters, aldehydes and acetals also have utility as intermediates in the synthesis of the corresponding 4-(2-hydroxyethylthiomethyl)pyridines.

    专利号:RU-2039050-C1
    优先权日:1989-09-26
    标 题:Derivatives of 1,2,4-triazole, optically inert or containing r- or s-configuration at c-2 and c-3 asymmetric centers, or their salts showing fungicide activity, and a method of their synthesis

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1038/s41557-023-01178-1
    摘要:Dief EM, Low PJ, Díez-Pérez I, Darwish N. Advances in single-molecule junctions as tools for chemical and biochemical analysis. Nat Chem. 2023 May;15(5):600–14. doi: 10.1038/s41557-023-01178-1.
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