CAS: 17412-37-2; 2-Methylimidazo[1,2-B]Pyridazine

相似化合物

14793-00-1 1936575-36-8 17412-39-4

上下游产品

3-aminopyridazine chloroacetone

📜哒嗪-3-胺,一氯丙酮 以 乙醇 用作溶剂,化学反应 16.0H,反应生成2-甲基咪唑并[1,2-B]吡嗪
参考文献: 3-(1H-Pyrazol-4-yl)Pyridine Allosteric Modulators Of The M4 Muscarinic Acetylcholine Receptor[fr] Modulateurs Allostériques De Type 3-(1H-Pyrazol-4-yl)Pyridine Du Récepteur Muscarinique M4 De L'Acétylcholine
标题: 3-(1H-Pyrazol-4-yl)Pyridine Allosteric Modulators Of The M4 Muscarinic Acetylcholine Receptor[fr] Modulateurs Allostériques De Type 3-(1H-Pyrazol-4-yl)Pyridine Du Récepteur Muscarinique M4 De L'Acétylcholine
摘要:本发明涉及吡唑并[4,3-B]吡啶化合物,其为m4毒蕈碱型乙酰胆碱受体的变构调节剂.本发明还涉及在可能治疗或预防神经和精神障碍以及涉及m4毒蕈碱型乙酰胆碱受体的疾病中使用所述化合物.本发明还涉及包含这些化合物的组合物.本发明还涉及在可能预防或治疗涉及m4毒蕈碱型乙酰胆碱受体的疾病中使用这些组合物.

专利信息

专利号:US-2024409557-A1
优先权日:2023-05-09
标 题 :5,6-fused and 6,6-fused bicyclic alcohols and ethers and compositions for use as 15-prostaglandin dehydrogenase modulators
发明人：GREENMAN KEVIN LLOYD; PICKRELL ALEXANDER J; LI KEXUE; AMEGADZIE ALBERT K; WANG HUI-LING; WEIRES NICHOLAS ANTHONY; ALLEN JOHN G; BOURBEAU MATTHEW P
权利人:AMGEN INC
摘要:The present disclosure provides novel 15-hydroxy-prostaglandin dehydrogenase inhibitors, pharmaceutical compositions comprising such compounds, and methods of using such compounds and compositions in treating 15-hydroxy-prostaglandin dehydrogenase-mediated disease. Also provided are methods of making such compounds and intermediates thereof. The compounds have a general Formula (A).Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (A).