CAS: 138775-05-0; (R)-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)(Methyl)Amino)-3-Phenylpropanoic Acid

相似化合物

77128-73-5 1161-13-3 13734-34-4

上下游产品

氯甲酸-9-芴基甲酯 (Fluorenylmethoxy)Carbonyl Chloride 28920-43-6
9-芴甲基-N-琥珀酰亚胺基碳酸酯 N-(9H-Fluoren-2-Ylmethoxycarbonyloxy)Succinimide 82911-69-1
N-Tert-Butoxycarbonyl-N-Methyl-D-Phenylalanine

Boc-D-苯丙氨酸置于盐酸体系中,用 1,4-二氧六环,N,N-二甲基甲酰胺 用作溶剂,化学反应 15.75H,反应生成N-芴甲氧羰酰基-N-甲基-D-苯丙氨酸
参考文献:首次全合成星野酰胺a
标题:首次全合成星野酰胺a
摘要:Hoshinoamides A,B 和 C,线性脂肽,是从海洋蓝藻caldora Penicillata中分离出来的,对氯喹敏感的恶性疟原虫具有有效的抗疟原虫活性.在此,我们通过液相和固相肽合成的组合描述了 Hoshinoamide A 的首次全合成.液相合成是为了提高ʟ-Val 3和n-Me-ᴅ-Phe 2的偶联产率.连接其他氨基酸的效率和收敛是通过固态合成实现的.我们的合成策略可以以高产率和高纯度合成目标肽
Doi:10.3762/bjoc.17.201

专利信息

专利号:CN-104284891-A
优先权日:2012-03-17
标 题:Conformational Restricted Total Synthesis of Macrocyclic Compounds

专利号:EP-2311786-A2
优先权日:2005-06-09
标题 :Methods for synthesis of encoded libraries

专利号:US-10017481-B2
优先权日:2012-03-17
标 题 :Conformationally constrained, fully synthetic macrocyclic compounds
发明人：OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; PIETTRE ARNAUD; GOSALBES JEAN-FRANÇOIS; THOMMEN MARC
权利人:POLYPHOR AG
摘要:The conformationally restricted, spatially defined macrocyclic ring system of formula (I) is constituted by three distinct molecular parts: Template A, conformation Modulator B and Bridge C. Macrocycles described by this ring system I are readily manufactured by parallel synthesis or combinatorial chemistry in solution or on solid phase. They are designed to interact with a variety of specific biological target classes, examples being agonistic or antagonistic activity on G-protein coupled receptors (GPCRs), inhibitory activity on enzymes or antimicrobial activity. In particular, these macrocycles show inhibitory activity on endothelin converting enzyme of subtype 1 (ECE-1) and/or the cysteine protease cathepsin S (CatS), and/or act as antagonists of the oxytocin (OT) receptor, thyrotropin-releasing hormone (TRH) receptor and/or leukotriene B4 (LTB4) receptor, and/or as agonists of the bombesin 3 (BB3) receptor, and/or show antimicrobial activity against at least one bacterial strain. Thus they are showing great potential as medicaments for a variety of diseases.

专利号:US-2024124517-A1
优先权日:2020-12-25
标题:Method for producing peptide compound containing n-substituted-amino acid residue
发明人：MORITA YUYA; NOMURA KENICHI
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:An object of the present invention is to provide a method for efficiently producing a high-purity peptide compound with a high yield. It has been found that the object can be achieved by supporting a peptide on a solid phase synthesis resin prior to a first elongation reaction in a solid phase process.

专利号:CN-114085269-A
优先权日:2021-11-12
标 题:A kind of all-solid-phase synthesis method of Hoshinoamide A

专利号:CN-114085269-B
优先权日:2021-11-12
标题:A total solid-phase synthesis method of Hoshinoamide A