CAS: 137391-68-5; (R)-4-Nitrobenzyl 2-Diazo-4-((2R,3S)-3-((R)-1-Hydroxyethyl)-4-Oxoazetidin-2-yl)-3-Oxopentanoate

专利信息

专利号:US-8093378-B2
优先权日:2006-04-28
标题 :Crystallization method for intermediates of carbapenem antibiotics
发明人：NISHINO KEITA; KOGA TERUYOSHI; FUKAE MASAFUMI; UEDA YASUYOSHI
权利人:NISHINO KEITA; KOGA TERUYOSHI; FUKAE MASAFUMI; UEDA YASUYOSHI; KANEKA CORP
摘要:An improved crystallization method for an azetidinone compound represented by the formula 1: , which is extremely useful as a common intermediate for the synthesis of 1β-methylcarbapenem compounds. The present method provides crystals having higher quality and stability than conventional crystals and excellent filterability at the time of recovery; and an azetidinone compound having a low content of impurity, and which has a controlled particle size distribution of crystals and improved handleability and stability. The crystallization is carried out by adding a hydrocarbon solvent to a solution in which an azetidinone compound extremely useful as a common intermediate for the synthesis of 1β-methylcarbapenem compounds is dissolved in the presence of a seed crystal in an amount of 200% by weight or less based on the weight of the azetidinone compound.