CAS: 137391-68-5; (R)-4-Nitrobenzyl 2-Diazo-4-((2R,3S)-3-((R)-1-Hydroxyethyl)-4-Oxoazetidin-2-yl)-3-Oxopentanoate
该化合物是合成有机化合物,其特点是复杂的环球结构.该化合物具有一种合成有机化合物,其特征是复杂的环球循环结构结构.该化合物的溶解性和稳定性各不相同,影响其在合成和配方中的应用.与许多有机化合物一样,应注意安全性和处理预防措施,特别是由于存在可能会对健康造成危害的溴原子.
- 英文名称(R)-4-Nitrobenzyl 2-Diazo-4-((2R,3S)-3-((R)-1-Hydroxyethyl)-4-Oxoazetidin-2-yl)-3-Oxopentanoate
- 中文名称F-9(美罗培南中间体)
- 其它别名(4-nitrophenyl)methyl (4R)-2-diazo-4-[(3S)-3-(1-hydroxyethyl)-4-oxo-azetidin-2-yl]-3-oxo-pentanoate
- CAS编号137391-68-5
- MFCD编号:MFCD11111990
- FDA UNII编号:9LYL8CRR6L
- 分子式:C17H18N4O7分子量:390.35
- 产品CID: 581254
- 产品分类原料药 → 抗生素类药物 → β-内酰胺酶抑制剂
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2902300000-甲苯
2905122000-异丙醇
2906210000-苄醇
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-8093378-B2
优先权日:2006-04-28
标题 :Crystallization method for intermediates of carbapenem antibiotics
发明人：NISHINO KEITA; KOGA TERUYOSHI; FUKAE MASAFUMI; UEDA YASUYOSHI
权利人:NISHINO KEITA; KOGA TERUYOSHI; FUKAE MASAFUMI; UEDA YASUYOSHI; KANEKA CORP
摘要:An improved crystallization method for an azetidinone compound represented by the formula 1: , which is extremely useful as a common intermediate for the synthesis of 1β-methylcarbapenem compounds. The present method provides crystals having higher quality and stability than conventional crystals and excellent filterability at the time of recovery; and an azetidinone compound having a low content of impurity, and which has a controlled particle size distribution of crystals and improved handleability and stability. The crystallization is carried out by adding a hydrocarbon solvent to a solution in which an azetidinone compound extremely useful as a common intermediate for the synthesis of 1β-methylcarbapenem compounds is dissolved in the presence of a seed crystal in an amount of 200% by weight or less based on the weight of the azetidinone compound.
