专利号:US-11161823-B2 优先权日:2019-03-11 标 题 :Anticancer 1,3-dioxane-4,6-dione derivatives and method of combinatorial synthesis thereof 发明人:ISLAM IMADUL; AL-KAYSI RABIH O; BOUDJELAL MOHAMED; ALI RIZWAN; NEHDI ATEF; ALGHANEM BANDAR 权利人:NAT GUARD HEALTH AFFAIRS; KING SAUD BIN ABDULAZIZ UNIV FOR HEALTH SCIENCES; KING ABDULLAH INTERNATIONAL MEDICAL RES CENTER; KING ABDULLAH INETRNATIONAL MEDICAL RES CENTER 摘要:Compounds, methods of synthesis, and methods of cancer treatment by arylidene-1,3-dioxane-4,6-diones. A Meldrum's acid-based chemistry and hybrid solid-liquid method. The method includes protection of ketone and aldehyde components and simultaneous immobilization on the solid phase, introduction of substituents, grafts and derivatives compatible with the protection, detachment and restoration of active carbonyl reactivity, reaction of ketone library with malonate, reacting of the products with the aldehyde library in liquid phase and separation of the products by preparative HPLC.
专利号:US-4469872-A 优先权日:1982-08-20 标 题:Substituted pyridyloxyphenoxyhydroxyketones 发明人:ANDERSON RICHARD J; LEE SHY-FUH 权利人:ZOECON CORP 摘要:Substituted phenoxyhydroxyketones, intermediates therefor, synthesis thereof, and the use of said compounds for the control of weeds.
专利号:US-2020290975-A1 优先权日:2019-03-11 标题 :Anticancer 1,3-dioxane-4,6-dione derivatives and method of combinatorial synthesis thereof
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