CAS: 127-48-0; 3,5,5-Trimethyloxazolidine-2,4-Dione

该化合物是被归类为二酮的有机化合物,主要以其用作抗convulsant 药物而闻名,特别是在治疗癫痫方面.三甲基乙酮的化学结构具有五人环,内含两个碳基组,有助于其药理特性.它一般是白色至白色的,在有机溶剂中溶解但水溶性有限的晶体固体.三甲基乙酮通过对大脑...

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上下游产品

diazomethane dimethadione dimethyl sulfate methyl iodide dimethadione

合成工艺路线路线简述

  • 合成目标产物 3,5,5-Trimethyloxazolidine-2,4-Dione 主要起始原料 5,5-Dimethyl-2-Thioxooxazolidin-4-One
  • (文献来源)合成步骤主要原料 5,5-Dimethyl-2-Thioxooxazolidin-4-One
📜3,5,5-Trimethyl-Oxazolidine-2,4-Dione 2-[(1-Phenyl-Ethylidene)-Hydrazone]置于盐酸体系中,用 乙醇 用作溶剂,化学反应生成三甲双酮
参考文献:Beyer,H.; Spoerl,R.,Chemische Berichte,1966,Vol. 99,P. 2719-2724
标题:Beyer,H.; Spoerl,R.,Chemische Berichte,1966,Vol. 99,P. 2719-2724

海关参考信息

专利信息


专利号:US-6159673-A
优先权日:1996-07-17
标 题:Oxonol compound, light-sensitive material and process for the synthesis of oxonol compound
发明人:NISHIGAKI JUNJI; DEGUCHI YASUAKI
权利人:FUJI PHOTO FILM CO LTD
摘要:An oxonol compound is represented by the following formula (I): in which Z is an atomic group that forms a cyclic amide ring; each of W1 and W2 independently is an atomic group that forms an acidic nucleus ring; and M is a cation. Other oxonol compounds, a light-sensitive material containing an oxonol compound and a process for the synthesis of an oxonol compound are also disclosed.

专利号:US-2008214827-A1
优先权日:2004-02-03
标 题:Synthesis of Cyanoimino-Benzoimidazoles
发明人:GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
权利人:EURO CELTIQUE SA
摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.

专利号:EP-4630405-A1
优先权日:2022-12-06
标题 :Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels

专利号:WO-2012014114-A1
优先权日:2010-07-30
标 题:Matrix metalloproteinase inhibitors
发明人:KHERA MANOJ KUMAR; SATTIGERI JITENDRA; SATTIGERI VISWAJANANI; YADAV NEERAJ KUMAR; KUMAR KEWAL; RAUF ABDUL REHMAN ABDUL; CLIFFE IAN A; BHATNAGAR PRADIP KUMAR; RAY ABHIJIT; SRIVASTAVA PUNIT; DASTIDAR SUNANDA GHOSH
权利人:RANBAXY LAB LTD; KHERA MANOJ KUMAR; SATTIGERI JITENDRA; SATTIGERI VISWAJANANI; YADAV NEERAJ KUMAR; KUMAR KEWAL; RAUF ABDUL REHMAN ABDUL; CLIFFE IAN A; BHATNAGAR PRADIP KUMAR; RAY ABHIJIT; SRIVASTAVA PUNIT; DASTIDAR SUNANDA GHOSH
摘要:The present invention relates to certain hydroxy propionic acid derivatives and the processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, dry eye, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by over-expression and over activation of a matrix metalloproteinase using the compounds.

专利号:CA-2555219-A1
优先权日:2004-02-03
标 题 :Synthesis of cyanoimino-benzoimidazoles

专利号:WO-2024123815-A1
优先权日:2022-12-06
标 题:Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels

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✅ COA系统入驻 | 共享模式

主要参考文献


1: Pastore V, Wasowski C, Higgs J, Mangialavori IC, Bruno-Blanch LE, Marder M. A synthetic bioisoster of trimethadione and phenytoin elicits anticonvulsant effect, protects the brain oxidative damage produced by seizures and exerts antidepressant action in mice. Eur Neuropsychopharmacol. 2014 Aug;24(8):1405-14. doi: 10.1016/j.euroneuro.2014.04.005. Epub 2014 May 2. doi: 10.1016/j.bmc.2012.12.033. Epub 2013 Jan 3. Chinese. doi: 10.1002/bdrb.20302. Epub 2011 Jun 2. Epub 2005 Sep 19. Review. Japanese. Review. Japanese. Review.

合成参考文献


参考文献:10.1001/jama.1970.03170260058019
摘要:Booker HE. Myasthenia Gravis Syndrome Associated With Trimethadione. JAMA. 1970 Jun 29;212(13):2262. doi: 10.1001/jama.1970.03170260058019.
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