CAS: 931-49-7; 1-Ethynylcyclohexene

该化合物是一种有机化合物,其特点是环状结构,并存在一个苯乙烯组;其特点是环环环,这是一个六人组成的碳环,一个双环,一个环内碳原子的一个环,一个环内碳原子的一个环,一个环内环环环,一个环内碳原子的一个环环,一个环环内环环.该化合物一般是没有色的,可粉色的黄色液体,有独特的气味.由于苯乙烯组中存在三联体,该化合物具有反应性,使其成为有机合成的有用中间体,特别是在生产各种药品和精美化学品方面.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号78-27-3 乙炔基环己醇 | CAS号932-66-1 1-乙酰基-1-环己烯 | CAS号17497-53-9 1-iod°Cyclohexene | CAS号1066-26-8 乙炔化钠,二甲苯溶液 | CAS号6209-75-2 Cyclohexane, 1-... | CAS号108-94-1 环己酮 | CAS号23293-77-8 Cyclohexanol,1-... | CAS号1940-19-8 1-乙烯基环己醇 | CAS号28075-50-5 1-环状己烯三氟甲烷磺酸 | CAS号31271-90-6 N-(对甲苯磺酰)吲哚 | CAS号4292-75-5 己基环己烷 | CAS号22031-58-9 2-Propenenitril... | CAS号201859-33-8 1-(2-iodoetheny... | CAS号21983-34-6 Cyclohexene,1-(... | CAS号1967-99-3 1H-Indazole,4,5... | CAS号932-66-1 1-乙酰基-1-环己烯 | CAS号27944-90-7 methyl 3-(cyclo... | CAS号245432-97-7 反式-2-(1-环己烯基)乙烯...

合成工艺路线路线简述

  • 75029-45-7 = 931-49-7
    反应条件:1.1 Solvents: Pentane
    标题:Photochemistry Of Strained Cycloalkynes
    作者:Meier,Herbert; Koenig,Peter
    参考文献:Nouveau Journal De Chimie 日期:1986 卷标:10(8-9) 页码:437-8]

    78-27-3 = 931-49-7
    反应条件:1.1 Catalysts: Ammonium Tetrafluoroborate,Ruthenium,Dichlorobis[μ-(Methanethiolato)]Bis[(1,2,3,4,5-η)-1,2,3,4,5-Pentameth... Solvents: 1,2-Dichloroethane; Rt; Rt -> 60 °C; 15 Min,60 °C
    标题:Ruthenium-Catalyzed Propargylic Substitution Reactions Of Propargylic Alcohols With Oxygen-,Nitrogen-,And Phosphorus-Centered Nucleophiles
    作者:Nishibayashi,Yoshiaki; Milton,Marilyn Daisy; Inada,Youichi; Yoshikawa,Masato; Wakiji,Issei; Et Al
    参考文献:Chemistry - A European Journal 日期:2005 卷标:11(5) 页码:1433-1451]

    17497-53-9 + 1112-00-1 = 931-49-7
    反应条件:1.1 Catalysts: Tetrakis(Triphenylphosphine)Palladium Solvents: Tetrahydrofuran
    标题:The Stille Reaction
    作者:Farina,Vittorio; Krishnamurthy,Venkat; Scott,William J.
    参考文献:Organic Reactions (Hoboken 日期:1997 卷标:50]

    78-27-3 = 931-49-7
    反应条件:1.1 Reagents: Triethylamine,Phosphorus Oxychloride Solvents: Dichloromethane; 20 Min,0 °C; 0 °C -> Rt; 3 H,Rt
    标题:Znii- And Aui-Catalyzed Regioselective Hydrative Oxidations Of 3-En-1-Ynes With Selectfluor. Realization Of 1,4-Dioxo And 1,4-Oxohydroxy Functionalizations
    作者:Jadhav,Appaso Mahadev; Gawade,Sagar Ashok; Vasu,Dhananjayan; Dateer,Ramesh B.; Liu,Rai-Shung
    参考文献:Chemistry - A European Journal 日期:2014 卷标:20(7) 页码:1813-1817]

    23293-77-8 = 931-49-7 [标题:Reaction Conditions
    标题:Formation Of α,β-Unsaturated Ketones From The Gas-Phase Pyrolysis Of α-Substituted Propargyl Esters
    作者:Trahanovsky,Walter S.; Emeis,Susan L.
    参考文献:Journal Of The American Chemical Society 日期:1975 卷标:97(13) 页码:3773-7]

    78-27-3 = 931-49-7
    反应条件:1.1 Reagents: Copper Sulfate
    标题:Kinetic Study Of The Diels-Alder Reaction Of Branched And Nonbranched Disymmetric Dienophiles
    作者:Gillois-Doucet,Jeannine; Rumpf,Paul
    参考文献:Compt. Rend. 日期:1956 卷标:243 页码:853-6]

    78-27-3 = 931-49-7
    反应条件:1.1 Reagents: Pyridine,Phosphorus Oxychloride; 0 °C; 5 H,Rt; Rt -> 0 °C1.2 Solvents: Water; Cooled
    标题:Borylation Of Propargylic Substrates By Bimetallic Catalysis. Synthesis Of Allenyl,Propargylic,And Butadienyl Bpin Derivatives
    作者:Zhao,Tony S. N.; Yang,Yuzhu; Lessing,Timo; Szabo,Kalman J.
    参考文献:Journal Of The American Chemical Society 日期:2014 卷标:136(21) 页码:7563-7566]

    78-27-3 = 931-49-7
    反应条件:1.1 Reagents: Alumina
    标题:Analogs Of Vitamin A
    作者:Sobotka,Harry; Chanley,J. D.
    参考文献:Journal Of The American Chemical Society 日期:1948 卷标:70 页码:3914-18]

    4187-88-6 = 931-49-7
    反应条件:1.1 Reagents: Isopropanol Catalysts: [(1,2,3,4,5-η)-1,2,3,4,5-Pentamethyl-2,4-Cyclopentadien-1-Yl][[2,2′-(Phenylphosp... Solvents: 1,2-Dichloroethane; 2 H,Rt -> 60 °C; Cooled
    标题:Preparation Of Thiolate-Bridged Dinuclear Ruthenium Complexes Bearing A Phosphine Ligand And Application To Propargylic Reduction Of Propargylic Alcohols With 2-Propanol
    作者:Yuki,Masahiro; Miyake,Yoshihiro; Nishibayashi,Yoshiaki
    参考文献:Organometallics 日期:2010 卷标:29(22) 页码:5994-6001]

    17497-53-9 + 1112-00-1 = 931-49-7
    反应条件:1.1 Catalysts: Tetrakis(Triphenylphosphine)Palladium Solvents: Tetrahydrofuran
    标题:Stereospecific Palladium-Catalyzed Coupling Reactions Of Vinyl Iodides With Acetylenic Tin Reagents
    作者:Stille,J. K.; Simpson,James H.
    参考文献:Journal Of The American Chemical Society 日期:1987 卷标:109(7) 页码:2138-52]

    78-27-3 = 931-49-7
    反应条件:1.1 Reagents: Phosphorus Oxychloride Solvents: Pyridine
    标题:Photosensitized Cis/trans Isomerization Of 1-(1-Propenyl)Cycloalkenes
    作者:Inman,Wayne D.; Sanchez,Kenneth A. J.; Chaidez,Manuel A.; Paulson,Donald R.
    参考文献:Journal Of Organic Chemistry 日期:1989 卷标:54(20) 页码:4872-81]

    78-27-3 = 931-49-7
    反应条件:1.1 Reagents: Phosphorus Oxychloride Solvents: Pyridine; 0 °C; 5 H,Rt1.2 Reagents: Water; Rt
    标题:Unearthing The Subtleties Of Rhodium(Ii)-Catalyzed Carbenoid Cycloadditions To Furans With An N-Sulfonyl-1,2,3-Triazole Probe
    作者:Bettencourt,Christian J.; Krainz,Tanja; Chow,Sharon; Parr,Brendan T.; Tracy,William F.; Et Al
    参考文献:Organic Letters 日期:2022 卷标:24(50) 页码:9290-9295]

    78-27-3 = 931-49-7
    反应条件:1.1 Reagents: Triethylamine,Methanesulfonyl Chloride Solvents: Dichloromethane; 0 °C; 0 °C -> Rt; Overnight,Rt1.2 Solvents: Water; Rt
    标题:Dual Proton/silver-Catalyzed Serial (5+2)-Cycloaddition And Nazarov Cyclization Of (E)-2-Arylidene-3-Hydroxyindanones With Conjugated Eneynes: Synthesis Of Indanone-Fused Benzo[cd]Azulenes
    作者:Zhu,Hai-Tao; Liang,Chun-Miao; Li,Ting-Yan; Li,Lin-Yan; Zhang,Rui-Ling; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2023 卷标:88(6) 页码:3409-3423]

    17988-44-2 = 931-49-7
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Methanol; 2 H,Rt
    标题:Iron(Ii)-Based Metalloradical Activation: Switch From Traditional Click Chemistry To Denitrogenative Annulation
    作者:Roy,Satyajit; Khatua,Hillol; Das,Sandip Kumar; Chattopadhyay,Buddhadeb
    参考文献:Angewandte Chemie 日期:2019 卷标:58(33) 页码:11439-11443]

    78-27-3 = 931-49-7
    反应条件:1.1 Reagents: Thionyl Chloride Solvents: Diethyl Ether,Pyridine
    标题:The Synthesis And Reduction Of Some Polyfunctional Acetylene Compounds
    作者:Newman,Melvin S.; Waltcher,Irving; Ginsberg,Helen F.
    参考文献:Journal Of Organic Chemistry 日期:1952 卷标:17 页码:962-70]

    78-27-3 = 931-49-7
    反应条件:1.1 Reagents: Triethylamine,Methanesulfonyl Chloride Solvents: Dichloromethane; 0 °C; 0 °C -> Rt; Overnight,Rt1.2 Reagents: Water; Rt
    标题:Dual Gold-Catalyzed Formal Tetradehydro-Diels-Alder Reactions For The Synthesis Of Carbazoles And Indolines
    作者:Wang,Hong-Fa; Wang,Shi-Yue; Qin,Tian-Zhu; Zi,Weiwei
    参考文献:Chemistry - A European Journal 日期:2018 卷标:24(68) 页码:17911-17914]

    6180-21-8 + 63006-94-0 = 931-49-7
    反应条件:1.1 2 H,40 °C1.2 Reagents: Oxonium
    标题:Lithium Chloroacetylide
    作者:Reich,Ieva L.; Reich,Hans J.
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2001 卷标:1]

    78-27-3 = 931-49-7
    反应条件:1.1 Reagents: Pyridine,Phosphorus Oxychloride; 0 °C; 5 H,Rt; Rt -> 0 °C1.2 Reagents: Water; Cooled
    标题:Copper-Catalyzed Silylation Reactions Of Propargyl Epoxides: Easy Access To 2,3-Allenols And Stereodefined Alkenes
    作者:Chang,Xi-Hao; Liu,Zheng-Li; Luo,Yun-Cheng; Yang,Chao; Liu,Xiao-Wei; Et Al
    参考文献:Chemical Communications (Cambridge 日期:2017 卷标:53(67) 页码:9344-9347]

    78-27-3 = 931-49-7
    反应条件:1.1 Reagents: Tosyl Chloride Solvents: Pyridine
    标题:Acetylenic Compounds. Xxvii. The Preparation And Properties Of The P-Toluenesulfonates Of Acetylenic Alcohols
    作者:Eglinton,G.; Whiting,M. C.
    参考文献:Journal Of The Chemical Society 日期:1950 卷标:3650 页码:3650-6]

    78-27-3 = 931-49-7
    反应条件:1.1 Reagents: Aluminum Sulfate
    标题:New Synthetic Rubbers. Ii. Homologs Of Chloroprene And Their Polymers
    作者:Carothers,Wallace H.; Coffman,Donald D.
    参考文献:Journal Of The American Chemical Society 日期:1932 卷标:54 页码:4071-6
📜炔环己醇置于吡啶,三氯氧磷体系中,化学反应 5.0H,以40%的收率获得产物1-乙炔基环己烷
参考文献:炔丙基环氧丙烷的铜催化硅烷化反应:易于获得2,3-烯丙醇和立体定义的烯烃
标题:炔丙基环氧丙烷的铜催化硅烷化反应:易于获得2,3-烯丙醇和立体定义的烯烃
摘要:已经开发了由铜催化剂催化的炔丙基环氧化物的高效甲硅烷基化反应.在温和的反应条件下,可以通过调节反应中使用的碱和溶剂,以中等至高收率选择性地获得三和四取代的官能化烯丙醇和烯烃.这项工作为从相同的炔丙基环氧化合物原料合成多官能化的2,3-烯醇和立体定义的烯烃提供了直接有效的方法.
DOI:10.1039/c7Cc04588C

海关参考信息

专利信息


专利号:US-2025026768-A1
优先权日:2023-06-30
标题:Method for the synthesis of axially chiral organoboron compounds
发明人：PING YIFAN; CHE CHI-MING
权利人:LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LTD
摘要:A highly efficient and atroposelective Rh-catalyzed [2+2+2] cycloaddition for the synthesis of axially chiral aryboron compounds is developed. The reactions of diynes and alkynylborons smoothly occur in an atom-economical manner, affording a variety of C—B atropisomers in excellent yields and enantioselectivities. The protocol features mild conditions, broad substrate scope, and good functional tolerance. The obtained C—B atropisomers show powerful synthetic applications in terms of producing novel chiral phosphine ligands.

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-6235957-B1
优先权日:1998-06-29
标 题 :Process for the preparation of cyclopropylacetylene
发明人：CHOUDHURY ANUSUYA
权利人:DU PONT PHARM CO
摘要:The present invention relates generally to novel methods for the synthesis of cyclopropylacetylene which is an essential reagent in the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one; a useful human immunodeficiency virus (HIV) reverse transcriptase inhibitor.

专利号:US-8674143-B2
优先权日:2008-10-15
标 题 :Synthesis of green ketone intermediate
发明人：BONRATH WERNER; LETINOIS ULLA; SCHUETZ JAN
权利人:BONRATH WERNER; LETINOIS ULLA; SCHUETZ JAN; DSM IP ASSETS BV
摘要:A process for the preparation of 1-ethynyl-3,3-dimethylcyclohexan-1-ol from dimedone by a reaction sequence of reduction and ethynylation and its further transformation into green ketone.

专利号:US-8487109-B2
优先权日:2007-07-03
标题:Process for the palladium-catalyzed coupling of terminal alkynes with aryl tosylates
发明人：RKYEK OMAR; NAZARE MARC; LINDENSCHMIDT ANDREAS; URMANN MATTHIAS; HALLAND NIS; ALONSO JORGE
权利人:RKYEK OMAR; NAZARE MARC; LINDENSCHMIDT ANDREAS; URMANN MATTHIAS; HALLAND NIS; ALONSO JORGE; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), n nwherein R1; R2; R3; R4; R5; J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process for aryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional aryl-1-alkynes of the formula I.

专利号:US-8420812-B2
优先权日:2007-07-03
标题:Process for the palladium-catalyzed coupling of terminal alkynes with heteroaryl tosylates and heteroaryl benzenesulfonates
发明人：RKYEK OMAR; NAZARE MARC; LINDENSCHMIDT ANDREAS; ALONSO JORGE; URMANN MATTHIAS; HALLAND NIS
权利人:RKYEK OMAR; NAZARE MARC; LINDENSCHMIDT ANDREAS; ALONSO JORGE; URMANN MATTHIAS; HALLAND NIS; SANOFI SA
摘要:A process for the palladium-catalyzed coupling of terminal alkynes with heteroaryl tosylates and heteroaryl benzenesulfonates n The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), n nwherein D, J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process of heteroaryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional heteroaryl-1-alkynes of the formula I.

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合成参考文献


摘要:Wang, K. K., Science of Synthesis, (2008) 44, 259.
摘要:Roy, K.-M., Science of Synthesis, (2010) 47, 1141.
摘要:Burmester, C.; Haß, O.; Faust, R., Science of Synthesis, (2008) 43, 274.
摘要:Batrice, R. J.; Karmel, I.-S. R.; Eisen, M. S., Science of Synthesis Knowledge Updates, (2012) 4, 185.
摘要:Anderson, E. A.; Lim, D. S. W., Science of Synthesis Knowledge Updates, (2015) 1, 73.
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