CAS: 7669-54-7; 2-Nitrophenyl Hypochlorothioite

该化合物是一种有机化合物,其特征是附于硝基代苯环的硫化氯功能组;其分子结构在相对于硫基氯化物组(-SCl)的正方位上有一个硝化物组 (-NO2),该物质影响其反应性和特性;该化合物一般是黄到褐的固体或液体,取决于其纯度和具体条件;其作用是有机合成中的试剂,特别是在形成硫烷和其他含硫化合物时. 2-硝基苯硫化物是反应性的,特别是核阴道,在水中可以进行水解,形成相应的硫酸.在处理该化合物时,安全防范是不可或缺的,因为它可以是腐蚀性的,如果吸入或接触皮肤,则可能构成健康风险.在冷,干燥的地方,远离湿度和不相容物质的地方适当储存对于保持其稳定性也至关重要.

结构式图片

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

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合成工艺路线路线简述

    1-(苄基磺酰基)-2-硝基苯置于磺酰氯体系中,化学反应生成 2-硝基苯硫氯
    参考文献:Derivatives Of Sulfenic Acids. Xliii. The Chlorinolysis Of Certain Aryl Benzyl Sulfides As A Route To Sulfenyl Chlorides1
    标题:Derivatives Of Sulfenic Acids. Xliii. The Chlorinolysis Of Certain Aryl Benzyl Sulfides As A Route To Sulfenyl Chlorides1
    摘要:
    DOI:10.1021/jo01042A507

    专利信息


    专利号:US-7015176-B2
    优先权日:2003-06-03
    标题 :Process for the synthesis of aryl sulfurpentafluorides
    发明人:BAILEY III WADE H; CASTEEL JR WILLIAM J; PESARESI RENO J; PROZONIC FRANK M
    权利人:AIR PROD & CHEM
    摘要:A process is described for the synthesis of an aryl sulfur pentafluoride compound. In one embodiment of the present invention, there is provided a process for preparing an aryl sulfurpentafluoride compound comprising: combining an at least one aryl sulfur compound with a fluorinating agent to at least partially react and form an intermediate aryl sulfurtrifluoride product; and exposing the intermediate aryl sulfurtrifluoride product to the fluorinating agent and optionally a fluoride source to at least partially react and form the aryl sulfurpentafluoride compound.

    专利号:US-2008221303-A1
    优先权日:2004-02-18
    标 题:Method for the Preparation of Peptide-Oligonucleotide Conjugates
    发明人:KATZHENDLER JEHOSHUA; KLAUZNER YAKIR; BEYLIS IRENA; MIZHIRITSKII MICHAEL; SHPERNAT YAACOV; ASHKENAZI BORIS; FRIDLAND DMITRI
    权利人:KATZHENDLER JEHOSHUA; KLAUZNER YAKIR; BEYLIS IRENA; MIZHIRITSKII MICHAEL; SHPERNAT YAACOV; ASHKENAZI BORIS; FRIDLAND DMITRI
    摘要:The present invention relates to the synthesis of peptide-oligonucleotide conjugates (POC). More specifically, the invention relates to a novel method for the preparation of peptide-oligonucleotide conjugates, which can be conducted under mild conditions on solid support, can be performed manually or by a synthesizer, can be used to synthesize alternating sequences of peptides and oligonucleotides, and is applicable to the synthesis of a wide variety of peptide-oligonucleotide conjugates constructed from alternate peptide and oligonucleotide blocks.

    专利号:US-2003232952-A1
    优先权日:2001-02-02
    标题:Design and synthesis of instant - degradable plastics
    发明人:ROSEN OREN
    摘要:A novel class of instant degradable synthetic polymeric plastics having the characteristics and properties of conventional forms of plastics is developed by providing a new application advantage of incorporating latent, labile, dormant chemical bond nuclei such as disulfide and sulfenyl derivatives of the plastic compounds with latent nucleophilic properties. The special advantage of the instant degradable polymers over the existing biodegradable and other degradable polymer counterparts, is their engineering and design, which makes the kinetics of their degradation instant, and the chemical and physical properties of their by-products allows soluble dissolution into non-toxic aqueous solvent media, thus enabling a practical treatment of waste and avoiding bio-hazardous pollution of the environment. These novel plastic products are made from a variety of compositions of polymers and their compatible nontoxic modifiers. The resulting novel instant degradable plastic products retain latent dormant solubility properties that are triggered upon mild chemical reaction, thus enabling cost effective and facile recycling of plastic refuge.

    专利号:US-8101665-B2
    优先权日:2007-12-17
    标题 :Process for synthesis of tritiated and deuterated thiorphan and acetorphan
    发明人:MASJEDIZADEH MOHAMMAND R; WU SHAO-YONG
    权利人:MASJEDIZADEH MOHAMMAND R; WU SHAO-YONG; ROCHE PALO ALTO LLC
    摘要:Methods for preparing tritium or deuterium labeled thiorphan comprising reacting a compound of formula j n nwherein m is from 1 to 5 and X is halo, with Z 2 wherein Z is tritium or deuterium, in the presence of a catalyst, to form a compound of formula kn n nwherein n is from 1 to 5, provided that n is less than or equal to m.

    专利号:US-7408023-B2
    优先权日:2001-04-06
    标 题 :Peptoids incorporating chemoselective functionalities
    发明人:HORN THOMAS; ZUCKERMANN RONALD N
    权利人:NOVARTIS VACCINES & DIAGNOSTIC
    摘要:Molecules having potential biological activity, particularly peptoids, that are conjugated to solid phase supports, spacer groups, and/or ligation moieties, and methods of their preparation, are described. In some instances, the molecules of the invention are made entirely by solid phase synthesis. In other instances, the spacer groups are hydrophilic and compositions containing them, and to solid phase synthesis of varied structure peptoids using chemoselective ligation moieties.

    专利号:US-3560521-A
    优先权日:1967-08-07
    标题:Blocking groups for cysteine containing peptides
    发明人:MILKOWSKI JOHN D; VEBER DANIEL F; HIRSCHMANN RALPH F
    权利人:MERCK & CO INC
    摘要:NOVEL PROTECTING GROUPS FOR PEPTIDES CONTAINING A CRYSTEINE RESIDUE. PROCESS FOR THE SYNTHESIS OF PEPTIDES CONTAINING A CYSTEINE RESIDUE WHEREIN THE MERCAPTO FUNCTION OF THE CYSTEINE RESIDUE IS PROTECTED BY A LABILE BLOCKING GROUP. NOVEL INTERMEDIATES USEFUL IN PEPTIDE SYNTHESIS.
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    主要参考文献

    参考标题:The Synthesis Of α-Aminonitriles Starting From The Corresponding Amino Acids. I. Use OfO-Nitrophenylsulfenyl As An N-Protecting Group
    作者:Katsuhiro Kawashiro,Hideyuki Yoshida,Shiro Morimoto |发布日期:1977.11
    摘要:N-O-Nitrophenylsulfenylamino Acid Amides Of Glycine, Alanine (Dl And L), Leucine (Dl And L), Methionine (Dl), Phenylalanine (Dl And L), And Proline (L) Were Dehydrated In Pocl3-Pyridine. The N-Protected α-Amino-Nitriles Obtained Were Treated With Anhydrous Hcl Affording The Corresponding α-Aminonitrile Hydrochlorides. The Optical Purity Of The L-α-Aminonitriles Was Well Retained.

    合成参考文献


    参考文献:10.1007/s00216-010-3471-8
    摘要:Roeser J, Bischoff R, Bruins AP, Permentier HP. Oxidative protein labeling in mass-spectrometry-based proteomics. Analytical and Bioanalytical Chemistry. 2010 Feb 13;397(8):3441–55. doi: 10.1007/s00216-010-3471-8.
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