CAS: 639-43-0; Akuammicine

上下游产品

3-(Tert-Butyl) 6-Methyl 1,2,3A,4,6A,7-Hexahydro-3H-Pyrrolo[2,3-D]Carbazole-3,6-Dicarboxylate
Methyl (3As,6Ar,11Br)-2,3,3A,4,6A,7-Hexahydro-1H-Pyrrolo[2,3-D]Carbazole-6-Carboxylate 1322613-98-8
(+/-)-Dehydrotubifoline
(+/-)-(1R*,7R*,8S*)-2-(E)-Ethylidene-7-<2-<5-(1,3-Dimethylhexahydro-2-Oxo-1,3,5-Triazine)>Phenyl>-4-Azatricyclo<5.2.2.04,8>Undecan-11-One
(1Rs,7Rs,8Sr)-7-(2-Nitrophenyl)-2-Vinylidene-4-Azatricyclo[5.2.2.04,8]Undecan-11-One
1-Chloroethyl (3Ar,7As)-3A-(2-Nitrophenyl)-4-Oxo-2,3,7,7A-Tetrahydroindole-1-Carboxylate
16-Decarbomethoxy-21-Oxotetrahydroalstonine
(3Ar,7As)-3A-(2-Nitrophenyl)-1-(4-Trimethylsilylbut-2-Ynyl)-2,3,7,7A-Tetrahydroindol-4-One 192431-40-6
1-Chloroethyl (3Ar,7As)-3A-(2-Nitrophenyl)-4-Oxo-2,3,5,6,7,7A-Hexahydroindole-1-Carboxylate
(+/-)-(19α,20α)-19-Methyloxayohimban-17,21-Dione

📜Methyl (3As,6Ar,11Br)-2,3,3A,4,6A,7-Hexahydro-1H-Pyrrolo[2,3-D]Carbazole-6-Carboxylate置于palladium Diacetate,三乙胺,N,N-二异丙基乙胺,三苯基膦体系中,用 乙腈 作为反应溶剂,化学反应 5.0H,反应生成 (19E)-2,16,19,20-四去氢枯苒-17-酸甲酯
参考文献:通过区域和立体控制的合作催化下的马钱子和白屈菜碱生物碱的对映选择性合成.
标题:通过区域和立体控制的合作催化下的马钱子和白屈菜碱生物碱的对映选择性合成.
摘要:我们描述的对映选择性合成马钱子和白屈菜生物碱.在第一种情况下,吲哚乙酸酯被确定为对映选择性协同异硫脲/ Pd催化α-烷基化的优秀伴侣亲核试剂.这提供了以高收率和出色的对映体诱导水平包含吲哚的立构中心的产品,其方式明显独立于n取代基.这导致了(−)‐ Akuammicine和(−)‐ Strychnine的简明合成.在第二种情况下,邻位表现不佳对映选择性协同异硫脲/ Ir催化的α-烷基化反应中的预取代肉桂酸亲电试剂可通过适当的取代基选择来克服,从而导致(+)-螯合碱,(+)-去甲螯合碱和(+)-螯合胺的对映选择性合成.
DOI:10.1002/anie.202005151

专利信息

专利号:US-12435094-B1
优先权日:2024-11-12
标题:Methods of preparing isomers, analogs, and synthetic derivatives from akuamma seeds
发明人：MITCHELL HAYWOOD MAX; PAGE CECIL; MERINO JOSEPH WILLIAM
权利人:MITCHELL HAYWOOD MAX; PAGE CECIL; MERINO JOSEPH WILLIAM
摘要:Methods are provided for the extraction, isolation, and synthesis of akuammine and other naturally occurring alkaloids from the seeds of the plant Picralima nitida (Akuamma), and their conversion to a variety of isomers, analogs, and synthetic derivatives.

专利号:US-11072613-B2
优先权日:2016-03-02
标 题:Compositions and methods for making terpenoid indole alkaloids
发明人：DE LUCA VINCENZO; QU YANG
权利人:WILLOW BIOSCIENCES INC
摘要:Methods that may be used for the manufacture of a class of chemical compounds known as terpenoid indole alkaloids, including tabersonine and catharanthine are provided. Compositions useful for the synthesis of terpenoid indole alkaloids, including tabersonine and catharanthine are also provided. The provided compounds are useful in the manufacture of chemotherapeutic agents.