专利号:US-9409877-B2 优先权日:2013-05-09 标 题:Process for the synthesis of 5-hydroxymethylfurfural from saccharides 发明人:CAPUZZI LUIGI; DIGIOIA FRANCESCA; CAROTENUTO GIUSEPPINA 权利人:NOVAMONT SPA 摘要:This invention relates to a process for the synthesis of 5-hydroxymethylfurfural (HMF) from saccharides. In particular this invention relates to a process for the dehydration of monosaccharides having 6 carbon atoms (hexoses), disaccharides, oligosaccharides, and polysaccharides to yield highly pure 5-hydroxymethylfurfural (HMF) in high yield.
专利号:US-11203780-B2 优先权日:2016-08-25 标 题 :Process for the enzymatic synthesis and amplification of nucleic acids 发明人:CHERKASOV DMITRY; BASLER NORBERT; BECKER CLAUS; HESS HANS-JOERG; MUELLER-HERMANN ANDREAS 权利人:AGCT GMBH 摘要:A method for amplification of nucleic acids in which substantially use is made of the fact that a pre-defined nucleic acid chain (target sequence) can be multiplied/amplified in the presence of a target sequence-specific activator oligonucleotide. The target sequence-specific activator oligonucleotide causes the separation of re-synthesized complementary primer extension products by strand displacement, so that a new primer oligonucleotide can attach to the respective template strand. The thus formed complex of a primer oligonucleotide and a template strand can initiate a new primer extension reaction. The thus formed primer extension products in turn function as templates, so that an exponential amplification reaction results. Amplification of a particular target sequence takes place more efficiently in case of perfect match complementary base pair formation between the activator oligonucleotide and the corresponding target sequence. Mismatches between the activator oligonucleotide and a particular target sequence can result in less efficient amplification. The efficiency of synthesis of perfect match target sequences and mismatch sequences can be measured and compared.
专利号:US-10030001-B2 优先权日:2014-10-16 标题 :Process for the production and isolation of 5-hydroxymethylfurfural 发明人:BASTIOLI CATIA; CAPUZZI LUIGI; CAROTENUTO GIUSEPPINA; DI MARTINO ANNA; FERRARI ADRIANO 权利人:NOVAMONT SPA 摘要:The present invention relates to a process for the synthesis of 5-hydroxymethyl furfural (HMF) comprising the steps of: 1) dehydrating at least one saccharide selected from monosaccharides having 6 carbon atoms and disaccharides, oligosaccharides or polysaccharides formed from units having 6 carbon atoms or mixtures thereof in the presence of at least one quaternary ammonium salt R3R′N+X−; in which: —R, which is the same or different, represents a C1-C16 substituted or unsubstituted alkyl group; —R′ belongs to the group consisting of: hydrogen, C1-C16 substituted or unsubstituted alkyl group, monocyclic substituted or unsubstituted aryl group; —X− represents an anion selected from chloride, bromide, iodide, fluoride, hydroxide, BF4− and PF6−; at a temperature of between 80 and 120° C., removing water from the reaction medium (dehydration stage) and obtaining a reaction mixture comprising the quaternary ammonium salt, HMF, any unreacted saccharide and having a water content of less than 30% by weight relative to the weight of the product HMF; 2) separating HMF from the said reaction mixture (separation stage).
专利号:WO-2013113319-A1 优先权日:2012-01-31 标题 :Process for the preparation of strontium ranelate, intermediate or hydrates thereof 发明人:KOFTIS THEOCHARIS V; ROHIT RAVIKANT SONI; BHARAT BECHARBHAI BODA; DIPAKKUMAR NARSIBHAI BHUT; VIMALKUMAR SUBHIRBHAI PATEL 权利人:PHARMATHEN SA; KOFTIS THEOCHARIS V; ROHIT RAVIKANT SONI; BHARAT BECHARBHAI BODA; DIPAKKUMAR NARSIBHAI BHUT; VIMALKUMAR SUBHIRBHAI PATEL 摘要:The present invention relates to an improved process for the synthesis of strontium ranelate compound of formula I or its hydrates thereof. More particularly, the present invention relates to an economically viable and industrially feasible process for the preparation of strontium ranelate, intermediate or its hydrates thereof.
专利号:US-2002058824-A1 优先权日:2000-11-15 标题:Solventless synthesis of hydrophilic phenol ester derivatives 发明人:MAJERCZAK VICTORIA ANN; GIBSON MICHAEL STEVEN; ORLANDO ROBERT JAMES 摘要:Process for preparing benzenesulfonate salts from an appropriately substituted acid chloride and a hydroxybenzenesulfonic acid is conducted in the absence of solvent, in a molar excess of acid chloride and in the presence of a phase transfer catalyst selected from quaternary ammonium and quaternary phosphonium salts and the target reaction product. The molar excess of the acid chloride is used to reduce the occurrence of gelation in the product.
专利号:US-5853555-A 优先权日:1997-04-03 标 题:Synthesis of onium hydroxides from onium salts 发明人:SHARIFIAN HOSSEIN; HULME DAVID R 权利人:SACHEM INC 摘要:The present invention provides a process for preparing onium hydroxide from a corresponding onium salt and for purifying onium hydroxide including providing an electrochemical cell containing a cathode, an anode, a divider and a bipolar membrane, the bipolar membrane having an anion selective side facing the anode and a cation selective side facing the cathode, wherein the divider is positioned between the cathode and the bipolar membrane, and the bipolar membrane is positioned between the divider and the anode, thereby defining a feed compartment between the divider and the bipolar membrane, a recovery compartment between the divider and the cathode, and a water compartment between the bipolar membrane and the anode; charging a solution containing at least one of the onium salt and the onium hydroxide to be purified to the feed compartment; charging a liquid electrolyte to the other compartments; passing a current through the electrochemical cell to produce the onium hydroxide in the recovery compartment; and recovering the onium hydroxide from the recovery compartment.
参考文献:10.2116/analsci.22.667 摘要:Tsujioka N, Imakura S, Nishi N, Kakiuchi T. Voltammetry of ion transfer across the electrochemically polarized micro liquid-liquid interface between water and a room-temperature ionic liquid, tetrahexylammonium bis(trifluoromethylsulfonyl)imide, using a glass capillary micropipette. Anal Sci. 2006 May;22(5):667–71. doi: 10.2116/analsci.22.667.