CAS: 56092-81-0; Ionomycin

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📜(2E,6E)-8-Bromo-3,7-Dimethylocta-2,6-Dienyl Acetate置于palladium Dihydroxide,四丙基高钌酸铵,4 A Molecular Sieve 吡啶,Chromium(Vi) Oxide,Titanium(Iv) Isopropylate,盐酸,叔丁基过氧化氢,4-二甲氨基吡啶,Lithium Hydroxide,正丁基锂,高氯酸,Samarium Diiodide,草酰氯,Bis(Acetylacetonate)Oxovanadium,L-(+)-Diisopropyl Tartrate,18-冠醚-6,三氟甲磺酸二丁硼,氢氟酸,4-甲基苯磺酸吡啶,双(三甲基硅烷基)氨基钾,Sodium Hydride,二甲基亚砜,N-甲基吗啉氧化物,三乙胺,N,N-二异丙基乙胺,2,3-二氯-5,6-二氰基-1,4-苯醌,Sodium Iodide体系中,用 四氢呋喃,乙二醇二甲醚,癸烷,乙醇,正己烷,二氯甲烷,环己烷,水,甲苯,乙腈,丁酮 作为反应溶剂,化学反应 130.58H,反应生成 罗红霉素
参考文献:使用开环策略进行离子霉素的全合成.
标题:使用开环策略进行离子霉素的全合成.
摘要:[结构:见正文]描述了聚醚抗生素离子霉素,钙离子载体的全合成.该合成证明了用于合成聚丙烯酸酯和脱氧聚丙烯酸酯亚基的开环方法的实用性,它们在合成的四个片段中的两个中被发现.
DOI:10.1021/ol025872F

专利信息

专利号:WO-2010144434-A1
优先权日:2009-06-09
标题 :Derivatives of mefloquine and associated methods for making and using
发明人：DOW GEOFFREY S; MILNER ERIN E; WIPF PETER; MO TINGTING
权利人:US OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY ON BEHALF OF U S; DOW GEOFFREY S; MILNER ERIN E; WIPF PETER; MO TINGTING
摘要:The present invention relates to new mefloquine derivatives and therapeutic compositions comprising one or more mefloquine derivatives. Mefloquine derivatives of the invention have a pentafluorosulfanyl moiety substitution at the 8-position. Certain mefloquine derivatives further include a quinoline methanol moiety substitution at the 4-position. The present invention also relates to new intermediate compounds useful in the synthesis of the mefloquine derivatives, which intermediates also have a pentafluorosulfanyl moiety substitution at the 8-position.

专利号:US-6238875-B1
优先权日:1991-03-12
标题:Diagnostic methods useful in the characterization of lymphoproliferative disease characterized by increased EPR-1
发明人：ALTIERI DARIO C
权利人:SCRIPPS RESEARCH INST
摘要:A new class of cellular receptors extensively homologous but not identical to coagulation factors V and VIII is identified. These new cell surface receptors are designated effector cell protease receptors (EPRs) and include EPR-1, which is shown to bind protease ligands. The DNA and amino acid residue sequences of the receptor are also described. The invention also discloses methods, sequences and vectors useful in the purification and synthesis of cellular receptors of the present invention. n Antibody compositions capable of immunoreacting with the receptor or with polypeptides containing the identified amino acid residue sequences and related therapeutic and diagnostic protocols are also described, as are polypeptides, compositions and methods relating to the inhibition of T lymphocyte proliferation using the antibodies disclosed herein. The receptors are also demonstrated to bind coagulation factor Xa, which binding is inhibited by various disclosed monoclonal antibodies to the receptors. The present invention also discloses polypeptides, antibodies and compositions capable of stimulating or co-stimulating lymphocyte proliferation.

专利号:US-10370455-B2
优先权日:2014-12-05
标题 :Identification of VSIG8 as the putative VISTA receptor (V-R) and use thereof to produce VISTA/VSIG8 agonists and antagonists
发明人：MOLLOY MICHAEL; GUO YALIN; ROTHSTEIN JAY; ROSENZWEIG MICHAEL
权利人:IMMUNEXT INC
摘要:The receptor for VISTA is identified (VSIG8) as well as the use of this receptor in the identification or synthesis of agonist or antagonist compounds, preferably antibodies, polypeptides and fusion proteins which agonize or antagonize the effects of VSIG8 and/or VISTA and/or the VSIG8/VISTA binding interaction. These antagonists may be used to suppress VISTA's suppressive effects on T cell immunity, and more particularly used in the treatment of cancer, or infectious disease. These agonist compounds may be used to potentiate or enhance VISTA's suppressive effects on T cell immunity and thereby suppress T cell immunity, such as in the treatment of autoimmunity, allergy or inflammatory conditions. Screening assays for identifying these agonists and antagonist compounds are also provided.

专利号:US-5214130-A
优先权日:1990-02-27
标题 :Synthesis of novel immunosuppressive cyclosporin analogs with modified amino acids at position-8
发明人：PATCHETT ARTHUR A; TAUB DAVID; GOEGELMAN ROBERT T
权利人:MERCK & CO INC
摘要:New immunosuppressive cyclosporin analogs are disclosed consisting of [dehydro-Ala]8 cyclosporins and derived therefrom cyclosporins having a sulfur containing amino acid at position-8.

专利号:US-9650407-B2
优先权日:2011-11-02
标 题 :Reprogramming of cellular adhesion
发明人：GARTNER ZEV JORDAN; SELDEN NICHOLAS SCOTT; TODHUNTER MICHAEL E; LIANG SAMANTHA ISABEL; WEBER ROBERT JOSEPH; JEE NOEL YOUNGHO; LIU JENNIFER S
权利人:UNIV CALIFORNIA
摘要:Disclosed are membrane-anchored polynucleotides, and compositions comprising the membrane-anchored polynucleotides. Also disclosed are the processes for the synthesis of these compounds, compositions comprising such compounds, and the use of such compounds and compositions in research and therapeutic applications.

专利号:US-9643934-B2
优先权日:2006-10-04
标 题:Process for synthesis of phenoxy diaminopyrimidine derivatives
发明人：DVORAK CHARLES ALOIS; GREEN KEENA LYNN; LEE GARY R
权利人:ROCHE PALO ALTO LLC
摘要:A method for preparing a compound of formula k n n n n n n n n n n n n or a salt or solvate thereof,n wherein R 1 is as defined herein, n n the method comprising treating a compound of formula j n n n n n n n n n n n n n n n n or a salt or solvate thereof, n with ammonia, to form the compound of formula k.