CAS: 4562-36-1; Gitoxin

该化合物是来自植物物种Digitalis(俗称Foxglove)的心球,其特点是能够抑制纳+/K+ATPase酶,导致心脏细胞细胞内钠和钙浓度增加.这一机制增强了心脏收缩的力度,使其有助于治疗某些心脏状况,如工伤和心脏衰竭.吉托辛呈现了一种狭窄的治疗指数,这意味着有效剂量和有毒剂量之间的差别很小,需要在治疗期间仔细监测血液水平.该物质还因其潜在的副作用而闻名,其中可包括胃肠扰动,视觉变化和心律.与其他心脏肌侧一样,吉他毒素的药典基因诸如肾功能和与其他药物的相互作用等因素而受到影响.由于它的强大影响和潜在毒性,应该严格在医学监督下使用基诺毒.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号1059-21-8 gitoxigenin 3-a... | CAS号527-52-6 D(+)-洋地黄毒糖 | CAS号545-26-6 芰皂配基 | CAS号7242-07-1 16-O-acetylgitoxin

合成工艺路线路线简述

    📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid 反应生成 格列苯脲杂质a
    参考文献:真正的洋地黄葡糖苷,紫草糖苷a和b.(9.mitteilungüberherzglucoside)
    标题:真正的洋地黄葡糖苷,紫草糖苷a和b.(9.mitteilungüberherzglucoside)
    摘要:
    DOI:10.1002/hlca.19350180117

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    专利信息


    专利号:US-10925977-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
    发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
    权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
    摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

    专利号:US-10814013-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:AU-2007308022-A2
    优先权日:2006-10-05
    标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:AU-2007308022-A1
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:US-2008107598-A1
    优先权日:2006-10-05
    标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications

    专利号:AU-2007308022-B2
    优先权日:2006-10-05
    标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

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    合成参考文献


    摘要:Toxicon., 8(85), 1970 []
    摘要:Pellegrin P, Lesne M. A new alternative in the field of cardiac glycosides: gitoxin. J Pharm Belg. 1986 Jan;41(1):39–53.
    参考文献:10.1021/jm0102811
    摘要:Farr CD, Tabet MR, Ball WJ, Fishwild DM, Wang X, Nair AC, Welsh WJ. Three-dimensional quantitative structure-activity relationship analysis of ligand binding to human sequence antidigoxin monoclonal antibodies using comparative molecular field analysis. J Med Chem. 2002 Jul 18;45(15):3257–70. doi: 10.1021/jm0102811.
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