CAS: 35737-10-1; Fmoc-ß-Ala-Oh

相似化合物

107-95-9 2304-94-1 3303-84-2

上下游产品

CAS号28920-43-6 芴甲氧羰酰氯(Fm°C-Cl) | CAS号107-95-9 β-丙氨酸 | CAS号82911-69-1 9-芴甲基-N-琥珀酰亚胺碳酸酯 | CAS号359009-97-5 4-((1-(4,4-dime... | CAS号29022-11-5 Fm°C-甘氨酸 | CAS号267410-86-6 9H-fluoren-9-yl... | CAS号172965-84-3 N-Fm°C-N-甲基-beta-丙氨酸 | CAS号183720-79-8 9H-fluoren-9-yl... | CAS号58579-19-4 3,4,6,11-tetrah...

Fmoc-Glycyl(Diazo)Methane置于silver Benzoate体系中,用 1,4-二氧六环 作为反应溶剂,化学反应 6.0H,以80%的收率获得产物fmoc-Beta-丙氨酸
参考文献:Homologation Of α-Amino Acids To β-Amino Acids Using Boc2O
标题:Homologation Of α-Amino Acids To β-Amino Acids Using Boc2O
摘要:在利用arndt-Eistert方法将n-羟基脲保护的α-氨基酸同系化为其β-同系物的过程中,使用boc2O作为偶联剂的方法已被描述.该同系化反应能够获得非常好的产率,且不会发生消旋化.使用boc2O作为偶联剂不仅使得过程易于放大,而且在成本方面也是经济有效的.
DOI:10.1039/b204652K

专利信息

专利号:US-2009171097-A1
优先权日:2005-11-22
标题 :Automated solid phase synthesis of pyrrole-imidazole polyamide
发明人：SUGIYAMA HIROSHI; DOHNO CHIKARA; FUKUDA NOBORU
权利人:SUGIYAMA HIROSHI; DOHNO CHIKARA; FUKUDA NOBORU
摘要:A synthesis method for pyrrole-imidazole polyamide is automated at a higher level and can produce a product with a high yield in a more stable manner. In a solid phase synthesis method, the automated synthesis of a polyimide can be promoted by using HCTU as a condensation-activator, the yield of a product can be increased by charging a monomer in a solid form, and a pyrrole-imidazole polyamide having any sequence can be synthesis by combining the synthesis method with a manual synthesis with an acid chloride.

专利号:US-12421628-B2
优先权日:2018-07-23
标题:Massively parallel enzymatic synthesis of nucleic acid strands
发明人：HORGAN ADRIAN; GODRON XAVIER; YBERT THOMAS; NICOL ROBERT
权利人:DNA SCRIPT
摘要:The invention is directed to methods for massively parallel template-free enzymatic synthesis of a plurality of different polynucleotides of predetermined sequences. In one aspect, methods of the invention employ large scale arrays of reaction sites each associated with at least one working electrode for controlling deprotection and deblocking steps at predetermined user selected sites. In another aspect, the invention provides template-free enzymatic synthesis with proofreading, wherein completed polynucleotides at predetermined reaction sites are sequenced using a sequencing by synthesis technique, particularly employing electrochemically labile blocking groups.

专利号:US-7138526-B1
优先权日:1999-06-15
标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
发明人：HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
权利人:AVENTIS PHARMA INC
摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

专利号:US-2024336649-A1
优先权日:2021-06-21
标 题 :Synthesis of covalent protein dimers that can inhibit myc-driven transcription
发明人：LOAS ANDREI; PENTELUTE BRADLEY L; POMPLUN SEBASTIAN; JBARA MUHAMMAD; SCHISSEL CARLY KATHERINE; RODRIQUEZ JACOB JOSHUA LEE; BUCHWALD STEPHEN LEFFLER; BOIJA ANN; KLEIN ISAAC; HAWKEN SUSANA WILSON; LI CHARLES HAN
权利人:MASSACHUSETTS INST TECHNOLOGY; WHITEHEAD INSTITUTE OF BIOMEDICAL RES
摘要:The disclosure relates to covalent protein dimers of MYC, MAX, and Omomyc; pharmaceutical compositions comprising the covalent protein dimers; methods of making the covalent protein dimers; and methods of treating disorders associated with MYC dysregulation (e.g., cancer) with the covalent protein dimers.

专利号:US-2023272006-A1
优先权日:2021-08-31
标题:Peptidomimetics and method of synthesis thereof
发明人：NEFZI ADEL
权利人:NEFZI ADEL; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
摘要:The subject invention provides compounds, peptidomimetics, and methods of synthesis thereof. The subject invention provides the synthesis and use of guanidino acids and/or poly guanidino acids not only as vehicles for drug delivery but as toolbox for drug discovery. The peptidomimetic of the subject invention comprises oligo(guanidino acid)s or poly(guanidino acid)s with guanidines as peptide bond surrogates. The incorporation of the guanidine as amide bond surrogates offers significant differences in polarity, hydrogen bonding capability, and acid-base character.

专利号:US-8178474-B1
优先权日:1999-04-21
标题 :Functionalised solid support for alpha-oxoaldehyde synthesis
发明人：MELNYK OLEG; FRUCHART JEAN-SEBASTIEN; BOUREL LINE; GRAS-MASSE HELENE
权利人:MELNYK OLEG; FRUCHART JEAN-SEBASTIEN; BOUREL LINE; GRAS-MASSE HELENE; PASTEUR INSTITUT; CENTRE NAT RECH SCIENT
摘要:The invention relates to a functionalised solid support for the synthesis of compounds comprising at least one α-oxoaldehyde function, to a process for preparing it and to its applications, in particular for the preparation of a library of organic compounds, of a diagnostic reagent, of a microtitration plate and of a biochip, such as a DNA chip. The present invention also relates to a process for the synthesis of organic compounds comprising at least one α-oxoaldehyde function and to the α-oxoaldehyde peptides obtained using this process.