CAS: 35595-03-0; 5-Hydroxy-2-(3-Hydroxy-4-Methoxyphenyl)-3,6-Dimethoxy-7-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-4H-Chromen-4-One
- 英文名称5-Hydroxy-2-(3-Hydroxy-4-Methoxyphenyl)-3,6-Dimethoxy-7-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-4H-Chromen-4-One
- 中文名称5-羟基-2-(3-羟基-4-甲氧基苯基)-3,6-二甲氧基-7-[(2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟基甲基)四氢吡喃-2-基]氧基苯并吡喃-4-酮
- IUPAC名称5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6-dimethoxy-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
- 其它别名centaurein; 2-(3-Hydroxy-4-methoxyphenyl)-3,6-dimethoxy-4-oxo-5-hydroxy-4H-1-benzopyran-7-yl β-D-glucopyranoside; 3,6,4'-Trimethoxy-5,3'-dihydroxy-7-(β-D-glucopyranosyloxy)flavone; 7-(β-D-Glucopyranosyloxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6-dimethoxy-4H-1-benzopyran-4-one; CENTAUREIN(RG)
- CAS编号35595-03-0
- FDA UNII编号:Y985P9U3S7
- 分子式:C24H26O13分子量:522.46
- 产品CID: 1364040
- 产品分类有机原料 → 苯丙烷和聚酮 → 黄酮类化合物
物理性质
- 熔点208～209°C
- 沸点836.7±65.0 °C(预测)
- 闪点285.2°C
- 密度1?+-.0.1 g/cm3(预测)
- pKa:5.90±0.40(预测)
- PSA:197.74
- LogP:1
- 折射率1.692
- 储存条件Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
- 产品应用该化合物是一种与CENTAUREA GENUS植物分离的天然裂变胶片,以其抗炎,抗氧化剂和抗微生物特性著称,研究其潜在的治疗用途,以管理与氧化性应激有关的条件,如心血管疾病和糖尿病,以及其防治微生物感染的能力.CENTUREIN通过清除自由基和抑制诸如环氧基(COX)等发炎过程中的关键酶来发挥作用.
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
2905399001-1,3-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Chang SL, Chiang YM, Chang CL, Yeh HH, Shyur LF, Kuo YH, Wu TK, Yang WC. Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-gamma expression. J Ethnopharmacol. 2007 Jun 13;112(2):232-6. doi: 10.1016/j.jep.2007.03.001. Epub 2007 Mar 7. 219(1):54-61. doi: 10.1016/j.taap.2006.11.026. Epub 2006 Dec 5. 64(2):116-9. doi: 10.1055/s-2006-957386. 29(9):2010. doi: 10.3390/molecules29092010.
5: Chiang YM, Chuang DY, Wang SY, Kuo YH, Tsai PW, Shyur LF. Metabolite profiling and chemopreventive bioactivity of plant extracts from Bidens pilosa. J Ethnopharmacol. 2004 Dec;95(2-3):409-19. doi: 10.1016/j.jep.2004.08.010. 27(21):7537. doi: 10.3390/molecules27217537.
7: Maldonado-Rojas W, Olivero-Verbel J, Marrero-Ponce Y. Computational fishing of new DNA methyltransferase inhibitors from natural products. J Mol Graph Model. 2015 Jul;60:43-54. doi: 10.1016/j.jmgm.2015.04.010. Epub 2015 Jun 3. 25(1):267-75.
合成参考文献
参考文献:10.1038/ncb3255
摘要:Lin R, Elf S, Shan C, Kang HB, Ji Q, Zhou L, Hitosugi T, Zhang L, Zhang S, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, Mitsche M, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Hurwitz SJ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Lei Q, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484–96.
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尽可能描述清楚需求与问题信息
