CAS: 343262-51-1; 2-Bromo-5-(Methylsulfonyl)Pyridine

相似化合物

445491-71-4 1227384-81-7 1245648-96-7

上下游产品

2-bromo-5-methylthiopyridine 2,5-dibromopyridine isopropylmagnesium chloride methanesulfonyl chloride 5-methylsulfonyl-2-[5-phenyl-3-difluoromethyl-1H-pyrazol-1-yl]pyridine 5-methanesulfonylpyridine-2-carboxylic acid ethyl ester 2-[3-(benzyloxy)-4-nitrophenoxy]-5-(methylsulfonyl)pyridine 2-[3-(1-methylethoxy)-4-nitrophenoxy]-5-(methylsulfonyl)pyridine

📜2-溴-5-(硫代甲基)吡啶置于间氯过氧苯甲酸体系中,用 二氯甲烷 用作溶剂,化学反应 2.0H,以95%的收率获得2-溴-5-甲砜基吡啶
参考文献:2-(3-二氟甲基-5-苯基吡唑-1-基)-5-甲磺酰吡啶(一种有效的,选择性的和口服活性的犬cox-2抑制剂)的体内和体外概况.
标题:2-(3-二氟甲基-5-苯基吡唑-1-基)-5-甲磺酰吡啶(一种有效的,选择性的和口服活性的犬cox-2抑制剂)的体内和体外概况.
摘要:描述了新型犬cox-2选择性抑制剂2-(3-二氟甲基-5-苯基吡唑-1-基)-5-甲磺酰吡啶的合成及其体外和体内特性.吡唑8在体外和离体全血测定中均表现出对犬cox-2的出色效价和选择性.这种新型的cox-2抑制剂在口服(po),静脉内(iv)和皮下(sc)给药后也显示出非常好的药代动力学特征(pk),并且在犬滑膜炎模型中显示出出色的体内功效.
Doi:10.1016/j.Bmc.2004.11.048

专利信息

专利号:US-2007275968-A1
优先权日:2004-09-07
标 题 :Substituted Biphenyl Derivative
发明人：KURATA HITOSHI; NISHIMATA TOYOKI; WATANABE YUKIKO; EBISAWA MASAYUKI; FUJIMOTO TEPPEI; KOBAYASHI HIDEKI
权利人:KURATA HITOSHI; NISHIMATA TOYOKI; WATANABE YUKIKO; EBISAWA MASAYUKI; FUJIMOTO TEPPEI; KOBAYASHI HIDEKI
摘要:The present invention relates to a biaryl derivative or a pharmacologically acceptable salt thereof having an excellent collagen-synthesis inhibition activity. A biaryl derivative having a structure represented by the following General Formula (I) or a pharmacologically acceptable salt thereof: n nwherein n R 1 represents a C 6 -C 10 aryl group which is substituted with one to three group(s) each independently selected from the group consisting of a group defined by formula R-L-, a di-(C 1 -C 6 alkyl)amino group, a di-(C 1 -C 6 alkyl)aminosulfonyl group, a hydroxyaminocarbonyl group, and a halogen atom, and so on; R represents a C 1 -C 6 alkyl group, and so on; L represents a sulfonyl group, an aminosulfonyl group, or a sulfonylamino group, and so on; R 2 represents a hydrogen atom, and so on; A represents a group defined by formula (II), (III), or (IV); R 3 represents a C 1 -C 6 alkyl group, and so on; and R 4 represents a C 1 -C 6 alkyl group, and so on.