CAS: 33708-72-4; Pachypodol

该化合物是一种自然形成的化学化合物,被归类为氟氯素,具体地说是一种花草酮,主要来自各种植物来源,特别是五氯酚* 的植物来源,该化合物以潜在的生物活动而著称,包括抗氧化剂,抗炎和抗微生物特性.帕奇波多尔展示了一种以铬骨质为特征的复杂结构,这是氟氯酮的典型特征,有助于它与生物系统的再活动与互动.该化合物因其潜在的治疗用途而引起了对药理研究的兴趣,尽管关于该化合物的功效和行动机制的详细研究仍在进行中.就溶性而言,如帕奇波尔多的氟化物一般在有机溶剂中溶解,但在水中的溶解性可能有限.与许多天然产品一样,提取和净化过程可以极大地影响用于研究和潜在医药用途的青激素的产量和纯度.

结构式图片

上下游产品

CAS号77813-31-1 2-(4-benzyloxy-... | CAS号70390-87-3 1-(2,6-dihydrox... | CAS号854873-13-5 4-benzoyloxy-3-... | CAS号117-39-5 槲皮素 | CAS号77-78-1 硫酸二甲酯

合成工艺路线路线简述

    📜2-(4-Benzyloxy-3-Methoxy-Phenyl)-5-Hydroxy-3,7-Dimethoxy-Chromen-4-One置于钯 Ethyl Acetate N-Hexane体系中,用 乙醇 用作溶剂,化学反应 1.0H,以there Was Obtained 0.58 G (90% Yield) Of 4',5-Dihydroxy-3,3',7-Trimethoxyflavone As Yellow Crystals的收率获得霍香酮醇
    参考文献:3-Alkoxyflavone Antiviral Agents
    标题:3-Alkoxyflavone Antiviral Agents
    摘要:揭示了含有3-烷氧基黄酮化合物作为其活性成分的抗病毒组合物.

    海关参考信息

    专利信息


    专利号:US-2019314312-A1
    优先权日:2016-07-11
    标题 :Combination therapy to increase endogenous nitric oxide (no) synthesis
    发明人:EREZ AYELET; STETTNER NOA
    权利人:YEDA RES & DEV
    摘要:Provided are uses of a therapeutically effective amount of citrulline for the manufacture of a medicament for treatment of a subject having an inflammatory bowel disease (IBD) and/or colon cancer. Also provided are pharmaceutical compositions comprising a therapeutic effective amount of citrulline and a therapeutically effective amount of a flavonoid for the treatment of an inflammatory bowel disease (IBD) and/or colon cancer and kits comprising same.

    专利号:US-12036300-B2
    优先权日:2021-03-31
    标题:Methods and compositions for improving skin
    发明人:LIAO I-CHIEN; BRIEVA PATRICIA; JUCHAUX FRANCK; BOUEZ CHARBEL; ZHENG QIAN; QIAN KUN
    权利人:OREAL
    摘要:A method for managing skin tone comprising reducing the synthesis of melanin by applying a skin treatment composition to skin. The skin treatment composition may include about 0.1 to about 25 wt. % of acetyl trifluoromethylphenyl valylglycine; about 0.5 to about 30 wt. % of a polyol; about 0.1 to about 30 wt. % of a silicone, fatty compound, or a mixtures thereof, wherein the skin treatment composition is an emulsion, and all weight percentages are based on the total weight of the skin treatment composition.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Arita M, Philipov S, Galabov AS. Phosphatidylinositol 4-kinase III beta is the target of oxoglaucine and pachypodol (Ro 09-0179) for their anti-poliovirus activities, and is located at upstream of the target step of brefeldin A. Microbiol Immunol. 2015 Jun;59(6):338-47. doi: 10.1111/1348-0421.12261. doi: 10.1021/acs.jafc.5b02842. Epub 2015 Sep 14. doi: 10.1002/ptr.2539. French. doi: 10.1371/journal.pone.0127060. eCollection 2015.
    9: Puripattanavong J, Weber S, Brecht V, Frahm AW. Phytochemical investigation of Aglaia andamanica. Planta Med. 2000 Dec;66(8):740-5. Chinese. doi: 10.1021/acs.jafc.6b00337. Epub 2016 Apr 12. Chinese. doi: 10.1021/acs.jafc.6b05390. Epub 2017 Mar 10. Chinese. Chinese.

    合成参考文献


    参考文献:10.1021/np50001a002
    摘要:Edwards JM, Raffauf RF, Le Quesne PW. Antineoplastic activity and cytotoxicity of flavones, isoflavones, and flavanones. J Nat Prod. 1979 Jan;42(1):85–91. doi: 10.1021/np50001a002.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知