CAS: 33643-94-6; 2-Phenyl-4(3H)-Pyrimidinone

该化合物是一个七环化合物,其核心为二点位置的二氢基,代之以一个苯基组;这一结构是有机合成的关键中间体,特别是在制药和生物活性分子的制作方面;其硬脚手架在药用化学方面提供多种用途,有利于改变有针对性的生物活动;该复合体在标准条件下表现出稳定性,便于处理和储存;其合成效用因与各种反应条件相容而进一步提高,使其对建设复杂的分子结构具有价值;研究人员赞赏其在开发具有潜在治疗用途的类似物,包括动脉抑制和抗微生物活动.

结构式图片

欧盟法规

C&L通报

上下游产品

CAS号1670-14-0 苄脒盐酸盐 | CAS号623-47-2 丙炔酸乙酯 | CAS号59938-07-7 (E)-1,1,1-三氯-4-... | CAS号14735-70-7 4-氧代-3-AZA-三环[4... | CAS号825-60-5 Benzamidic acid... | CAS号141-90-2 2-硫脲嘧啶 | CAS号960-16-7 三丁基苯基锡 | CAS号5751-20-2 2-甲硫基-4-嘧啶酮 | CAS号98-88-4 苯甲酰氯 | CAS号151227-74-6 1-oxido-1-pheny... | CAS号26786-28-7 2-苯基-5-溴-4-羟基嘧啶 | CAS号14790-42-2 4-氯-2-苯基嘧啶

合成工艺路线路线简述

  • 合成目标产物 4-Hydroxy-2-Phenylpyrimidine 主要起始原料 2-Thiouracil And Tributylphenyltin
  • (文献来源)合成步骤主要原料 2-Thiouracil 和 Tributylphenyltin
📜4-Phenyl-3,5-Diazatricyclo[6.2.1.02,7]Undeca-3,9-Dien-6-One 以88%的收率获得产物
参考文献:Stajer G.; Szabo E.; Bernath G.; Sohar P.,Magy. Kem. Folyoirat,92,(1986) N 5,234-236
标题:Stajer G.; Szabo E.; Bernath G.; Sohar P.,Magy. Kem. Folyoirat,92,(1986) N 5,234-236

海关参考信息

专利信息


专利号:US-6271392-B1
优先权日:1994-10-07
标题:Intermediates useful for the synthesis of 1-arylpyrrole pesticides
发明人:CHENE ALAIN; HUBER SCOT KEVIN
权利人:RHONE POULENC INC
摘要:The present invention pertains to novel 3-substituted-4-thiopyrrole intermediates for the preparation of 1-arylpyrrole compounds that are useful for the control of insects, acarids and nematodes. n The compounds, including their isomers, e.g., diastereomers and optical isomers, are compounds of a general formula (I) n wherein the structural variables are as defined in the description.

专利号:EP-0708090-B1
优先权日:1994-10-07
标 题:Intermediates useful for the synthesis of pesticides

专利号:EP-0708090-A1
优先权日:1994-10-07
标题:Intermediates useful for the synthesis of pesticides

专利号:DE-69529049-T2
优先权日:1994-10-07
标题 :Intermediates for the synthesis of pesticides

专利号:US-12233062-B2
优先权日:2018-09-26
标 题 :Heterocyclic derivatives useful as SHP2 inhibitors
发明人:HAN HUIFENG; GAO PANLIANG; MA CUNBO; KANG DI
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:This invention provides a compound of formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention provides a pharmaceutical composition comprising the said compound.

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品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 431.
摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 257.
参考文献:10.1007/bf00058171
摘要:Roh MS, Kahky MP, Oyedeji C, Klostergaard J, Wang L, Curley SA, Lotzová E. Murine Kupffer cells and hepatic natural killer cells regulate tumor growth in a quantitative model of colorectal liver metastases. Clinical & Experimental Metastasis. 1992 Sep;10(5):317–27. doi: 10.1007/bf00058171.
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