CAS: 32214-80-5; Lupeol Palmitate

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羽扇豆醇 Lupeol 545-47-1

📜羽扇豆醇,棕榈酸置于4-二甲氨基吡啶,N,N'-二异丙基碳二亚胺体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 羽扇烯基棕榈酸酯
参考文献:Gastroprotective Properties Of Lupeol-Derived Ester: Pre-Clinical Evidences Of Lupeol-Stearate As A Potent Antiulcer Agent
标题:Gastroprotective Properties Of Lupeol-Derived Ester: Pre-Clinical Evidences Of Lupeol-Stearate As A Potent Antiulcer Agent
摘要:Lupeol (1) Was Isolated From Hexane Branch Extract Of Maytenus Salicifolia And The Lupeol Stearate (2),Lupeol Palmitate (3),Lupeol Myristate (4),Lupeol Laurate (5) And Lupeol Caprylate (6) Were Obtained Reacting 1 With An Adequate Carboxylic Acid. Swiss Mice Were Treated With Vehicle,Carbenoxolone Or Lupeol Esters Before Administration Of Ethanol/hcl Or Indomethacin. Additionally,The Involvement Of Nitric Oxide (No),Sulfhydryl Compounds (Np-Sh),Alpha-2 Adrenergic Receptors (Alpha 2-Ar) And Prostaglandins (Pge) In Antiulcer Effects Was Investigated Using Appropriate Inhibitors Or Antagonist. Oxidative And Inflammatory Parameters Were Measured After Euthanasia And Anti-Secretory Effects Was Evaluated In Pylorus-Ligated Rats. Ethanol/hcl Ulcerated The Gastric Mucosa By 64.45 +/-6.58 Mm(2),Which The Oral Treatment With 1,4 And 6 (10 Mg/kg),And 3 And 5 (30 Mg/kg) Reduced The Lesion Area. Interestingly,2 Reduced The Gastric Ulcer By Oral Route In A Potent And Dosedependent Manner (Ed50 = 0.40 Mg/kg),Which Was Accompanied By The Increase In Reduced Glutathione Levels And By The Reduction Of Lipids Peroxidation And Myeloperoxidase And Superoxide Dismutase Activities. Moreover,2 (0.1 Mg/kg) Also Prevented The Ulcerogenesis By Intraperitoneal Route. The Participation Of No,Np-Sh,Alpha 2-Ar And Pge In 2-Mediated Gastroprotection Was Confirmed. In Indomethacin-Induced Ulcer,2 (1 Mg/kg,P.O) Also Reduced The Ulcer Area And Increased The Pge 2 Levels. However,2 Did Not Alter The Gastric Acid Secretion. Therefore,These Findings Indicate That The Obtention Of 2 Potentiated The Antiulcer Activity Of 1 And That This Compound Can Elicit Gastroprotective Action Due A Diversified Mode Of Action.
DOI:10.1016/j.Cbi.2020.108964