CAS: 29783-26-4; Cis-Cyclopent-4-Ene-1,3-Diol

相似化合物

54664-61-8 60410-16-4 4157-01-1

上下游产品

cyclopentadiene endoperoxide thiourea cis-3,5-dibrom°Cyclopentene tetraethylammonium acetatemaleic anhydride cis-3.5-bis-(3.5-dinitro-benzoyloxy)-cyclopentene-(1)cis-3.5-bis-(3.5-dinitro-benzoyloxy)-cyclopentene-(1) cis-cyclopentane-1,3-diolcis-cyclopentane-1,3-diol (3aR,4R,6S,6aR)-3-Phenyl-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole-4,6-diol

Cis-3,5-二乙酰氧基-1-环戊烯置于potassium Carbonate体系中,用 甲醇 用作溶剂,化学反应 2.0H,以40 G的收率获得顺式-4-环戊烯-1,3-二醇
参考文献:由糠醇制备旋光的2-环戊烯-1,4-二醇衍生物
标题:由糠醇制备旋光的2-环戊烯-1,4-二醇衍生物
摘要:描述了几种顺式-单-4-O-保护的-2-环戊烯-1,4-二醇的制备和酶促拆分.该方法开始于廉价的糠醇,并有助于制备数克量的各种受保护的旋光性2-环戊烯-1,4-二醇衍生物.描述了使用或将4-O-保护的2-环戊烯酮立体选择性地还原为顺-单-O-保护的-2-环戊烯-1,4-二醇.随后对这些顺式-(+/-)-Mono-O进行了胰酶促进的立体选择性酰化反应-经保护的环戊烯-1,4-二醇得到中等至极好的对映选择性的相应醇和乙酸酯.
Doi:10.1016/s0040-4020(96)01169-6

专利信息

专利号:US-5144034-A
优先权日:1990-04-06
标题 :Process for the synthesis of cyclopentene derivatives of purines
发明人：JOHNSON M ROSS; PEEL MICHAEL R; STERNBACH DANIEL D
权利人:GLAXO INC
摘要:This invention relates to a new process for preparing certain optically active cyclopentene derivatives and novel intermediates used in this process. In particular, the invention concerns the synthesis of the 1'R-cis isomer of carbovir, (1'R-cis)-2-amino-1,9-dihydro-9[4-(hydroxymethyl)-2-cyclopenten-1-yl]-6H-purin-6-one, an antiviral agent.

专利号:US-5126452-A
优先权日:1990-04-06
标 题 :Synthesis of purine substituted cyclopentene derivatives
发明人：VINCE ROBERT; PETERSON MARK L; LACKEY JOHN W; MOOK JR ROBERT A; PARTRIDGE JOHN J
权利人:GLAXO INC
摘要:This invention relates to new process for preparing certain optically active purine substituted cyclopentene derivatives and novel intermediates used in this process. In particular, the invention concerns the synthesis of the 1R-cis isomer of carbovir, (1R-cis)-amino-1,9-dihydro-9-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-6H-purin-6-one, an antiviral agent, and certain intermediates.

专利号:US-5057630-A
优先权日:1990-04-06
标 题 :Synthesis of cyclopentene derivatives
发明人：LACKEY JOHN W; MOOK JR ROBERT A; PARTRIDGE JOHN J
权利人:GLAXO INC
摘要:This invention relates to a new process for preparing certain optically active purine substituted cyclopentene derivatives including the antiviral agent, carbovir, and novel intermediates used in this process. In particular, this invention concerns a synthesis of (1R-cis)-4-hydroxymethyl-2-cyclopenten-1-ol, an intermediate in this process.

专利号:US-5241069-A
优先权日:1990-04-06
标题 :Carbonate intermediates for the synthesis of purine substituted cyclopentene derivatives
发明人：VINCE ROBERT; PETERSON MARK L; LACKEY JOHN W; MOOK JR ROBERT A; PARTRIDGE JOHN J
权利人:GLAXO INC; UNIV MINNESOTA
摘要:This invention relates to the new process for preparing the 1R-cis isomer of carbovir, (1R-cis)-amino-1,9-dihydro-9-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-6H-purin-6-one, an antiviral agent and intermediates of the formula (Vlb) use in that process ##STR1## wherein X is chloro, bromo or iodo and R is (C 1-6 ) alkyl.

专利号:US-4952710-A
优先权日:1988-10-07
标 题:Cyclopenteneheptenoic acid derivatives and method of preparation thereof
发明人：BABIAK KEVIN A; CAMPBELL ARTHUR L
权利人:SEARLE & CO
摘要:This invention relates to a novel cyclopenteneheptenoic acid derivative having the following formula wherein R1 is hydrogen, -COCH3, -COCF3, -CO-phenyl, or a hydroxyl protecting group such as tetrahydropyranyl, tetrahydrofuranyl, or tri-lower alkylsilyl; wherein R2 is -CH2OR1, -COOH, -COOR, -CHO, -CH2-OSi(R12)3, wherein R is lower alkyl and each R12 is independently lower alkyl or aryl; and wherein Y is ethylene, cis-vinylene, trans-vinylene, or acetylene. Also disclosed is a novel process for preparation of the above-defined cyclopenteneheptenoic acid derivative. This process involves coupling of a higher order cuprate complex with a chiral cyclopentene compound. The resultant product is particularly useful as a starting compound for high yield synthesis of optically active prostaglandins.

专利号:US-6974834-B2
优先权日:2003-01-14
标 题 :Process for preparing enantiomerically enriched (1S,4R) 1-acetoxy-4-hydroxycyclopent-2-ene
发明人：HENEGAR KEVIN EDWARD
权利人:AGOURON PHARMA
摘要:This invention relates to a process for the synthesis of enantiomerically enriched (1S,4R) 1-acetoxy-4-hydroxycyclopent-2-ene of Formula I, a compound useful as an intermediate in the synthesis of prostaglandins and prostanoids.