CAS: 2675-77-6; Chloroneb

该化合物是氯化芳香烃类的有机化合物,在2和5个位置和1和4个位置上,用两种甲基氧组(-OCH3)和两个氯原子(-Cl)替换一个苯环,在2和5个位置和两个氯原子(-OCH3),在1和4位位置上,该化合物一般没有颜色,在室内温度下不见青色,黄色固体,以其在水中的溶性相对较低而闻名,同时在乙醇和二氯甲烷等有机溶剂中更易溶解.氯和甲氧基化合物的存在影响其化学再活动,使其有可能成为有机化学中各种合成应用的候选物.此外,它可能展示生物活动,这可能会引起药理学研究的兴趣.在处理该化合物时,应当采取安全防范措施,因为氯化化合物可能对环境和健康造成风险.建议从光处适当储存在冷干的地方保持其稳定性.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

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CAS号150-78-7 对苯二甲醚 | CAS号615-93-0 2,5-二氯-1,4-苯醌 | CAS号123-31-9 对苯二酚 | CAS号824-69-1 2,5-二氯对苯二酚 | CAS号77-78-1 硫酸二甲酯 | CAS号74-88-4 碘甲烷 | CAS号10026-13-8 五氯化磷 | CAS号7782-50-5 氯气 | CAS号18113-14-9 2,5-Dichloro-4-... | CAS号24909-17-9 2,5-Cyclohexadi... | CAS号824-69-1 2,5-二氯对苯二酚 | CAS号615-93-0 2,5-二氯-1,4-苯醌

合成工艺路线路线简述

    对苯二甲醚置于benzyltrimethylazanium Tetrachloro-λ3-Iodanuide体系中,用 溶剂黄146 用作溶剂,化学反应 1.0H,以38%的收率获得地茂散
    参考文献:Halogenated Volatiles From The Fungus Geniculosporium And The Actinomycete Streptomyces Chartreusis
    标题:Halogenated Volatiles From The Fungus Geniculosporium And The Actinomycete Streptomyces Chartreusis
    摘要:在真菌geniculosporium的头空间提取物中检测到了两种未经鉴定的氯化挥发性化合物x和y.它们的质谱指向x为氯二甲氧基苯,Y为二氯二甲氧基苯的结构.X和y的一些构造异构体的质谱已包含在我们的数据库中,证明它们非常相似,因此无法完全确定结构.为了明确结构,我们通过合成或从商业供应商处获得了x和y的所有可能的构造异构体.质谱和气相色谱保留时间的比较严格确定了这两种氯化挥发性化合物的结构.氯化挥发性化合物并不是很常见,但溴化或甚至碘化的挥发性化合物更为罕见.令人惊讶的是,从streptomyces Chartreusis的头空间提取物中发现了甲基2-碘苯甲酸酯,这是一种新的天然产物,丰富了碘化天然产物家族.
    Doi:10.3762/bjoc.9.311

    海关参考信息

    专利信息


    专利号:WO-2025056767-A1
    优先权日:2023-09-15
    标题 :Process for the preparation of enantiomerically enriched aliphatic amines
    发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

    专利号:US-9968097-B2
    优先权日:2012-05-30
    标题:Composition comprising a biological control agent and a fungicide selected from inhibitors of the lipid membrane synthesis, the melanine biosynthesis, the nucleic acid synthesis or the signal transduction
    发明人:WACHENDORFF-NEUMANN ULRIKE; ANDERSCH WOLFRAM; STENZEL KLAUS; SPRINGER BERND
    权利人:BAYER CROPSCIENCE AG
    摘要:The present invention relates to a composition comprising at least one biological control agent. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts.

    专利号:US-2007232495-A1
    优先权日:2006-03-24
    标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
    发明人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.

    专利号:WO-2021074309-A1
    优先权日:2019-10-16
    标 题:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives as fungicides for combating specific phytopathogens
    发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; SEN INDIRA; BIERI STEPHANE; DIGGELMANN MARTIN
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-3,4-dihydroisoquinoline derivative of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale) when spayed on plants), as well as comparative data against three prior art compounds (e.g. pages 52 to 85; formulation examples; examples A1 to A3; table E; compounds E.01 to E.187; biological examples). Exemplary compounds are e.g.: 5-bromo-1-(8-fluoro-3-quinolyl)spiro[4H-isoquinoline-3,1'- cyclopropane] (example A1) 5-bromo-1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline (example A2) 1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline-5-carbonitrile (example A3)

    专利号:WO-2021074311-A1
    优先权日:2019-10-16
    标题:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives as fungicides for combating specific phytopathogens
    发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; BIERI STEPHANE; DIGGELMANN MARTIN
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola, Monographella nivalis, Fusarium culmorum and/or Gibberella zeae when spayed on plants) (e.g. pages 47 to 55; examples A1 and A2; compounds E.01 to E.17; table E). An exemplary compounds is e.g.: 3-(5-bromo-3,3-dimethyl-2,4-dihydro-1 H-isoquinolin-1-yl)-8-fluoro- quinoline (example A1)

    专利号:US-8937089-B2
    优先权日:2004-07-01
    标 题:Synergistic mixtures of anthranilamide invertebrate pest control agents
    发明人:ANNAN ISAAC BILLY; FLEXNER JOHN LINDSEY; PORTILLO HECTOR EDUARDO; LAHM GEORGE PHILIP; SELBY THOMAS PAUL; STEVENSON THOMAS MARTIN
    权利人:ANNAN ISAAC BILLY; FLEXNER JOHN LINDSEY; PORTILLO HECTOR EDUARDO; LAHM GEORGE PHILIP; SELBY THOMAS PAUL; STEVENSON THOMAS MARTIN; DU PONT
    摘要:Disclosed are mixtures and compositions for controlling invertebrate pests relating to combinations comprising (a) 3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide, and its N-oxides, and suitable salts thereof n n n n n n n n n n n n andn na component (b) wherein the component (b) is at least one compound or agent selected from neonicotinoids, cholinesterase inhibitors, sodium channel modulators, chitin synthesis inhibitors, ecdysone agonists, lipid biosynthesis inhibitors, macrocyclic lactones, GABA-regulated chloride channel blockers, juvenile hormone mimics, ryanodine receptor ligands, octopamine receptor ligands, mitochondrial electron transport inhibitors, nereistoxin analogs, pyridalyl, flonicamid, pymetrozine, dieldrin, metaflumizone, biological agents, and suitable salts of the foregoing.n n n n n n Also disclosed are methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a mixture or composition of the invention.
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    主要参考文献

    [参考文献]: E K Frederick, Et Al. Degradation Of Chloroneb, Triadimefon, And Vinclozolin In Soil, Thatch, And Grass Clippings. Bull Environ Contam Toxicol. 1994 Oct;53(4):536-42.
    [参考文献]: H M Müller, Et Al. [参考文献]: Acta Histochem Suppl. 1984:30:347-51.
    [参考文献]: Jhonyson Arruda Carvalho Guedes, Et Al. Matrix Effect In Guava Multiresidue Analysis By Quechers Method And Gas Chromatography Coupled To Quadrupole Mass Spectrometry. Food Chem. 2016 May 15:199:380-6.
    [参考文献]: M A Ramesh, Et Al. The Camp Signal Transduction Pathway Mediates Resistance To Dicarboximide And Aromatic Hydrocarbon Fungicides In Ustilago Maydis. Fungal Genet Biol. 2001 Apr;32(3):183-93.
    [参考文献]: N M Martinez-Rossi, Et Al. Two-Way Selection Of Mutants And Revertants To Chloroneb Resistance In Aspergillus Nidulans. Mutat Res. 1982 Sep;96(1):31-9.

    合成参考文献


    摘要:Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-317
    摘要:Galadi A et al; Chemosphere 30: 1655-69 (1995)
    摘要:USEPA/Office of Water; Federal-State Toxicology and Risk Analysis Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and Guidelines (11/93) To Present
    摘要:IATA. Dangerous Goods Regulations. 45 th Ed. Montreal, Canada and Geneva, Switzerland. International Air Transport Association. Dangerous Goods Regulations, 2004., p. 208
    摘要:Association of American Railroads/Bureau of Explosives; Emergency Handling of Hazardous Materials in Surface Transportation. Association of American Railroads. Pueblo, CO. 2002., p. 695
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