CAS: 26472-41-3; (6S)-3,5,6-Trihydroxy-2-(3-Methylbutanoyl)-4,6-Bis(3-Methylbut-2-Enyl)Cyclohexa-2,4-Dien-1-One

上下游产品

CAS号4374-93-0 3-methyl-1-[2,4... | CAS号504-85-8 4-甲基-3-戊烯酸 | CAS号78-84-2 异丁醛 | CAS号67-64-1 丙酮 | CAS号78-78-4 异戊烷

📜Humulon置于(1S,2S)-4-环己烯-1,2-二胺,硫酸体系中,用 异丙醇,Hexanes,水 用作溶剂,化学反应生成律草酮
参考文献:Cis 3,4-Dihydroxy-2-(3-Methylbutanoyl)-5-(3-Methylbutyl)-4-(4-Methylpentanoyl)Cyclopent-2-En-1-One Derivatives,Substantially Enantiomerically Pure Compositions And Methods
标题:Cis 3,4-Dihydroxy-2-(3-Methylbutanoyl)-5-(3-Methylbutyl)-4-(4-Methylpentanoyl)Cyclopent-2-En-1-One Derivatives,Substantially Enantiomerically Pure Compositions And Methods
摘要:本申请提供了顺式3,4-二羟基-2-(3-甲基丁酰基)-5-(3-甲基丁基)-4-(4-甲基戊酰基)环戊-2-烯-1-酮衍生物及其基本对映纯组合物.这些衍生物包括(+)-(4S,5R)-3,4-二羟基-2-(3-甲基丁酰基)-5-(3-甲基丁基)-4-(4-甲基戊酰基)环戊-2-烯-1-酮,(-)-(4R,5S)-3,4-二羟基-2-(3-甲基丁酰基)-5-(3-甲基丁基)-4-(4-甲基戊酰基)环戊-2-烯-1-酮,以及它们的盐和晶体.该申请还提供了使用所披露的化合物和组合物来激活pparγ,激活gpr120,抑制炎症,并治疗对pparγ调节敏感的病症,对gpr120调节敏感的病症以及代谢紊乱如糖尿病的方法.

专利信息

专利号:US-7919125-B2
优先权日:2001-06-20
标 题:Modulation of inflammation by hops fractions and derivatives
发明人：TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE M
权利人:METAPROTEOMICS LLC
摘要:A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandin selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops.

专利号:US-2007036742-A1
优先权日:2005-08-09
标题 :Methods and compositions for modulating hair growth or regrowth
发明人：ROUFS JAMES B; DUVEL LANE A; FAST DAVID J; GLYNN KELLY M
权利人:ACCESS BUSINESS GROUP INT LLC
摘要:The present invention relates to compositions and methods for modulating hair growth or regrowth. The compositions of the present invention comprise extracts of one or more of the following: Boswellia serrata, Undaria pinnatifida, green tea (e.g., Camellia sinensis ), shiso, Pureraria mirifica, luteolin (e.g. Perilla ocymoides leaf extract), astilbin, vitamin E, amentoflavone, tetrahydropiperine, licochalcone, astaxanthin, red clover, Brassica juncea, unfermented green rooibos, enzyme CoQ10, salvia, ximenynic acid, hops oleoresin, apple, soy, saw palmetto, or ellagic extract, or any derivative thereof. In particular, the compositions and methods of the present invention can be used to stimulate or increase hair growth and/or prevent or slow the loss of hair by having one or more of the following functions: (a) inhibiting synthesis of DHT; (b) inhibiting proteasomal activity; (c) inhibiting IL-1 activity; (d) increasing vascularization; (e) increasing expression of vascular endothelial growth factor; (f) increasing expression of keratinocyte growth factor; (g) inhibiting inflammation; or (h) acting as an antibacterial.

专利号:US-2008031986-A1
优先权日:2005-12-09
标题:Protein kinase modulation by hops and acacia products
发明人：TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; HALL AMY J; KONDA VEERA; PACIORETTY LINDA M; DESAI ANU
权利人:METAPROTEOMICS LLC
摘要:Botanical compounds to modulate kinase activity are disclosed. The compounds and methods disclosed also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively. The compositions contain at least one fraction isolated or derived from hops or Acacia.

专利号:US-8257754-B2
优先权日:2002-10-21
标 题:Synergistic compositions that treat or inhibit pathological conditions associated with inflammatory response
发明人：TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE M
权利人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE M; METAPROTEOMICS LLC
摘要:A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

专利号:US-8486457-B2
优先权日:2002-10-21
标 题:Compositions that treat or inhibit pathological conditions associated with inflammatory response
发明人：TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE
权利人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE; METAPROTEOMICS LLC
摘要:A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

专利号:US-8557306-B2
优先权日:2001-06-20
标 题 :Compositions that treat or inhibit pathological conditions associated with inflammatory response
发明人：TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE
权利人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE; METAPROTEOMICS LLC
摘要:A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.