CAS: 243128-37-2; 4-Fluoro-3-Methoxybenzonitrile

上下游产品

CAS号870837-21-1 3-甲氧基-4-(4-甲基-1... | CAS号870837-18-6 3-甲氧基-4-(4-甲基-1... | CAS号508177-67-1 2-氟-5-(氨甲基)苯甲醚

4-氟-3-甲氧基苯乙酸置于氧气,Copper(II) Trifluoroacetate,尿素体系中,用 二甲基亚砜 用作溶剂,化学反应 24.5H,以98%的收率获得4-氟-3-甲氧基苯腈
参考文献:铜催化的脱羧cn三键形成:O2气氛下由苯乙酸直接合成苯甲腈
标题:铜催化的脱羧cn三键形成:O2气氛下由苯乙酸直接合成苯甲腈
摘要:发现在氧气气氛下,苯乙酸与尿素的铜催化反应可生成苄腈.该反应通过一系列脱羧,双氧活化,Ch键官能化和以尿素为氮源形成腈的过程而顺利进行.发现分子氧在该转化中起关键作用.该反应代表了一种以环境友好的方式并具有非常好的官能团耐受性形成苄腈的新颖方法.
Doi:10.1002/adsc.201301001

专利信息

专利号:US-2012053165-A1
优先权日:2009-03-03
标 题:Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators
发明人：ALLEN MARTIN PATRICK; AM ENDE CHRISTOPHER WILLIAM; BRODNEY MICHAEL AARON; DOUNAY AMY BETH; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SCHWARTZ JACOB BRADLEY; TRAN TUAN PHONG
权利人:ALLEN MARTIN PATRICK; AM ENDE CHRISTOPHER WILLIAM; BRODNEY MICHAEL AARON; DOUNAY AMY BETH; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SCHWARTZ JACOB BRADLEY; TRAN TUAN PHONG; PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.