CAS: 22737-36-6; O-(Trimethylsilyl)Hydroxylamine

相似化合物

1066-40-6 10519-96-7 18027-10-6

上下游产品

trimethylsilyl amine 1,1,1,3,3,3-hexamethyl-disilazane chloro-trimethyl-silane ethyl>hydroxylamineN-1-methyl-1-4-(benzyloxy)phenylethylhydroxylamine N-(dimethylphenylsilyl)-N'-(trimethylsiloxy)urea N-Trityl-L-Methioninhydroxylamid

1,1,1-三甲基硅烷胺置于盐酸羟胺体系中,用 乙醚,氨 用作溶剂,化学反应生成O-(三甲基硅)羟胺
参考文献:Frainnet,E. Et Al.,Comptes Rendus Des Seances De L'Academie Des Sciences,Serie C: Sciences Chimiques,1970,Vol. 270,P. 240-242
标题:Frainnet,E. Et Al.,Comptes Rendus Des Seances De L'Academie Des Sciences,Serie C: Sciences Chimiques,1970,Vol. 270,P. 240-242

专利信息

专利号:US-9938282-B2
优先权日:2014-02-05
标 题:Expedient synthesis of sitagliptin
发明人：JANAGANI SATYANARAYANA; THADURI VENKATESHWAR KUMAR; VAMARAJU RAVISANKAR
权利人:STEREOKEM INC
摘要:Novel intermediates are disclosed as intermediates for preparation of a Sitagliptin. A novel synthetic method to prepare Sitagliptin using the said intermediates is also disclosed.

专利号:US-6566524-B2
优先权日:2001-12-21
标题 :Methods for synthesis of amino-tetrahydroisoquinoline-sulfonamide hydroxamic acids
发明人：LIU SONG; RENNELLS WILLIAM MARTIN
权利人:PROCTER & GAMBLE
摘要:Methods of preparing an amino-substituted-tetrahydroisoquinoline-sulfonamide hydroxamic acid include the steps of providing an amino-substituted-tetrahydroisoquinoline-carboxylate attached to a solid support; reacting the ring nitrogen of the amino-tetrahydroisoquinoline-carboxylate with a sulfonyl chloride; and cleaving the intermediate from the solid support to form an amino-tetrahydroisoquinoline-sulfonamide hydroxamic acid.

专利号:US-5332825-A
优先权日:1993-10-13
标题 :Single vessel synthesis of aminoacetonitriles
发明人：BUCKLAND PAUL R
权利人:EASTMAN KODAK CO
摘要:This invention relates to two processes for preparing aminoacetonitriles in one vessel under anhydrous conditions. Process I involves the steps of: (A) reacting trimethylsilyl cyanide and an aldehyde in a water miscible amide solvent to obtain a silyl blocked cyanohydrin solution; (B) adding a catalytic amount of water to the silyl blocked cyanohydrin solution from Step (A); and (C) passing ammonia through the solution to obtain an aminoacetonitrile. Process II involves the steps of: (A') reacting trimethylsilyl cyanide with an aldehyde in the absence of solvent to form a silyl blocked cyanohydrin; (B') adding a water miscible amide solvent to the silyl blocked cyanohydrin from Step (A') to obtain a solution; and (C') passing ammonia through the solution to obtain an aminoacetonitrile. Aminoacetonitriles are important intermediates in the preparation of amino acids, thiadiazoles, acylaminoacetonitriles, and imidazole derivatives.

专利号:US-6743811-B2
优先权日:1999-07-28
标 题:Oxazalidinone compounds and methods of preparation and use thereof
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; GADWOOD ROBERT C
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. Oxazolidinones as disclosed herein can be readily synthesized and used in a variety of applications including use as antimicrobial agents. In one embodiment, a variety of thioamidomethyloxazolidinones and methods for their synthesis and use are provided.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-2002058815-A1
优先权日:2001-12-21
标 题 :Methods for synthesis of amino-tertahydroisoquinoline-sulfonamide hydroxamic acids