CAS: 1999-33-3; (S)-4-Amino-2-(2-Aminoacetamido)-4-Oxobutanoic Acid

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CAS号974-17-4 N-[(Benzyloxy)c... | CAS号35181-18-1 pht-gly-asn-oh | CAS号974-17-4 N-[(Benzyloxy)c... | CAS号7664-41-7 氨

📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于乙醇,钯体系中,化学反应生成Nα-甘氨酰-L-天冬酰胺酸
参考文献:Leach; Lindley,Australian Journal Of Chemistry,1954,Vol. 7,P. 173,178
标题:Leach; Lindley,Australian Journal Of Chemistry,1954,Vol. 7,P. 173,178

专利信息

专利号:US-5945312-A
优先权日:1996-04-15
标 题 :Synthesis of fluorophore-labeled DNA
发明人：GOODMAN MYRON F; REHA-KRANTZ LINDA J
权利人:UNIV SOUTHERN CALIFORNIA; UNIV ALBERTA
摘要:Sequencing methods and methods for synthesizing DNA probes using mutant bacteriophage T4 DNA polymerases which have increased ability to incorporate modified nucleotides for the synthesis of long or short chains of complementary, modified, e.g., fluorophore-labeled DNA. In general, the mutant T4 DNA polymerases retain 3'→5' exonuclease activity; hence, reduction or elimination of 3'→5' exonuclease activity is not a prerequisite for efficient synthesis of a complementary fluorophore-labeled or other modified DNA. In fact, retention of 3'→5' exonuclease activity increases accuracy of DNA replication, because these exonucleases proofread or edit the product of DNA replication.

专利号:WO-9720061-A1
优先权日:1995-11-30
标题:Synthesis of hyaluronic acid
发明人：WONG CHI-HUEY; DELUCA CLAUDIO
权利人:SCRIPPS RESEARCH INST; WONG CHI HUEY; DELUCA CLAUDIO
摘要:A preparative enzymatic synthesis of hyaluronic acid (HA) from UDP-N-acetyl-D-glucosamine (UDP-GlcNAc) and UDP-glucuronic acid (UDP-GlcA) catalyzed by hyaluronic acid synthase is coupled with regeneration of the sugar nucleotides. Polymerizing UDP-GlcA and UDP-GlcNAc to form hyaluronic acid results in the formation of released UDP. The released UDP is, in turn, employed in the regeneration of UDP-GlcA and UDP-GlcNAc. Use of the released UDP for regenerating UDP-GlcA and UDP-GlcNAc prevents a build-up of these compounds and prevents or reduces feed back inhibition of the hyaluronic acid synthase reaction that would otherwise be caused by such build-up. Accordingly, the product yield is enhanced by the recycling of these compounds.

专利号:US-12024731-B2
优先权日:2017-05-03
标 题 :Methods and enzyme catalysts for the synthesis of non-canonical amino acids
发明人：BOVILLE CHRISTINA E; BRINKMANN-CHEN SABINE; BULLER ANDREW R; ROMNEY DAVID K; PRIER CHRISTOPHER K; KOCH PHILIPP; SCHEELE REMKES A
权利人:CALIFORNIA INST OF TECHN
摘要:The present disclosure provides methods for preparing β-substituted tryptophan compounds. The methods include: combining i) an unsubstituted indole or a substituted indole, ii) a β-substituted serine, and iii) a tryptophan synthase β-subunit (i.e., a TrpB); and maintaining the resulting mixture under conditions sufficient to form the β-substituted tryptophan. The TrpB contains at least one amino acid mutation which promotes formation of an amino-acrylate intermediate. New TrpB variants and new β-substituted tryptophan analogs are also described.

专利号:US-6699981-B2
优先权日:1999-09-22
标题 :Method and compositions for improved polynucleotide synthesis
发明人：YANG SHUWEI
权利人:GENECOPOEIA INC
摘要:The sensitivity and specificity of polynucleotide synthesis is increased by protecting the 3'-end of an oligonucleotide used as a primer in the synthesis of the polynucleotide. Protection of the 3'-end of an oligonucleotide prevents non-specific chain elongation. Removal of blocking group an elevated temperature, using a thermostable enzyme, permits template-specific polynucleotide synthesis. The present invention also provides oligonucleotides with a 3' end protected by a blocking group and a thermostable enzyme capable of removing the blocking group at an elevated temperature. The compositions and methods of the invention are very useful in a variety of techniques for DNA/RNA amplification and analysis, including medical genetics research and diagnosis, pathogen detection, forensic, and animal and plant genetics applications, among others.

专利号:WO-9217496-A1
优先权日:1991-03-18
标题 :Isolation and sequence of the acetyl coa:deacetylcephalosporin acetyltransferase gene
发明人：MATHISON LORILEE; SOLIDAY CHARLES L; RAMBOSEK JOHN A
权利人:PANLABS INC
摘要:The invention relates to a DNA sequence with a nucleotide sequence encoding a polypeptide in a host cell having Cephalosporin C synthetase (DAC acetyltransferase) activity which is the last enzyme in the synthesis of cephalosporins. Embodiments of the invention relate to methods and compositions for detecting the gene or its product, mutants and hybrids of the gene, replicative cloning and expression vectors, and processes for preparing recombinant DAC acetyltransferase polypeptide useful for host cell synthesis of, as well as cell-free synthesis of natural and synthetic cephalosporin antibiotics.

专利号:US-6075183-A
优先权日:1997-04-11
标 题:Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants
发明人：KNUTZON DEBORAH; MUKERJI PRADIP; HUANG YUNG-SHENG; THURMOND JENNIFER; CHAUDHARY SUNITA
权利人:ABBOTT LAB; CALGENE LLC
摘要:The present invention relates to compositions and methods for preparing poly-unsaturated long chain fatty acids in plants, plant parts and plant cells, such as leaves, roots, fruits and seeds. Nucleic acid sequences and constructs encoding fatty acid desaturases, including Δ5-desaturases, Δ6-desaturases and Δ12-desaturases, are used to generate transgenic plants, plant parts and cells which contain and express one or more transgenes encoding one or more desaturases. Expression of the desaturases with different substrate specificities in the plant system permit the large scale production of poly-unsaturated long chain fatty acids such as docosahexaenoic acid, eicosapentaenoic acid, α-linoleic acid, gamma-linolenic acid, arachidonic acid and the like for modification of the fatty acid profile of plants, plant parts and tissues. Manipulation of the fatty acid profiles allows for the production of commercial quantities of novel plant oils and products.