CAS: 166815-96-9; Tert-Butyl 4-((Tosyloxy)Methyl)Piperidine-1-Carboxylate

该化合物是一种受保护的管状衍生物,在4号位置上有一个四氟氧基甲基组,其特性为四氯氧基甲基组,该化合物是有机合成的多用途中间体,特别是在建造复杂的含氮的剑桥时.乙丁基碳基(Boc)组在基本条件下提供稳定性,同时允许在酸性条件下有选择地取消保护,促进进一步实现功能化.

英文名称Tert-Butyl 4-((Tosyloxy)Methyl)Piperidine-1-Carboxylate
中文名称1-Boc-4-(p-甲苯磺酰氧甲基)哌啶
IUPAC名称tert-butyl 4-((tosyloxy)methyl)piperidine-1-carboxylate
其它别名凡德他尼中间体1; Tert-Butyl 4-({[(4-Methylphenyl)Sulfonyl]Oxy}Methyl)Piperidine-1-Carboxylate
CAS编号166815-96-9
MFCD编号:MFCD05864740
EINECS号:682-427-8
分子式:C18H27NO5S
分子量:369.48
产品CID: 844528
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: DARTVAOOTJKHQW-UHFFFAOYSA-N
InChI=1S/C18H27NO5S/c1-14-5-7-16(8-6-14)25(21,22)23-13-15-9-11-19(12-10-15)17(20)24-18(2,3)4/h5-8,15H,9-13H2,1-4H3…
计算化学: 氢键受体数5.0氢键供体数0.0可旋转键数4.0

相似化合物

123855-51-6 118156-56-2 916078-39-2

MSDS等安全信息

GHS象形图
GHS符号GHS09;
注释: Environment
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
严重眼刺激类别2
水生慢性毒性类别2
警示词Warning
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H411 |对水生生物有毒并具有长期持续影响.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险等级IRRITANT
危险品标志Xi

欧盟法规

C&L通报

上下游产品

合成工艺路线路线简述

合成目标产物 N-Tert-Butoxycarbonyl-4-(4-Toluenesulfonyloxymethyl)Piperidine 主要起始原料 Triethylenediamine And 2-Methylpentane And Tosyl Chloride And N-Boc-4-Piperidinemethanol
(文献来源)合成步骤主要原料 Triethylenediamine 和 2-Methylpentane 和 Tosyl Chloride 和 N-Boc-4-Piperidinemethanol

4-哌啶甲醇置于吡啶,4-二甲氨基吡啶体系中,用二氯甲烷用作溶剂,化学反应 15.0H,反应生成1-N-Boc-4-(4-甲基苯磺酰氧甲基)哌啶
参考文献:设计,合成和评估新型的有机磷酸酯抑制乙酰胆碱酯酶的非季铵盐活化剂
标题:设计,合成和评估新型的有机磷酸酯抑制乙酰胆碱酯酶的非季铵盐活化剂
摘要:本文描述了一系列新的非季铵盐共轭物,用于神经活性剂和农药抑制hache的活化.发现通过哌啶与氨基苯甲酰胺缀合的取代的水杨醛将产生沙林,Vx和塔宾抑制的hache的有效活化剂,例如l6M1R3,L6M1R5至l6M1R7,L4M1R3和l4M1R5至l4M1R7.在体外首次进行了农药抑制hache的复活实验.尽管它们的效率不如奥比多肟,但与2-Pam相比,它们中的一些被认为是同等或更有效的再活化剂.发现在大多数情况下,引入外围位点配体可以增加肟对抑制的hache的结合亲和力,从而导致更大的再活化能力.
Doi:10.1016/j.Bioorg.2018.09.025

海关参考信息

2902300000-甲苯
2905122000-异丙醇
2905143000-叔丁醇
2912110000-甲醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-9815816-B2
优先权日:2005-09-30
标题 :Chemical process for the synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline
发明人：BLIXT JORGEN; GOLDEN MICHAEL DAVID; HOGAN PHILIP JOHN; MARTIN DAVID MICHAEL GLANVILLE; MONTGOMERY FRANCIS JOSEPH; PATEL ZAKARIYA; PITTAM JOHN DAVID; SEPENDA GEORGE JOSEPH; SQUIRE CHRISTOPHER JOHN; WRIGHT NICHOLAS CARTWRIGHT ALEXANDER
权利人:ASTRAZENECA AB; GENZYME CORP
摘要:The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilizing said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

专利号:US-2019263782-A1
优先权日:2005-09-30
标题 :Chemical Process for the Synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline

专利号:US-10344015-B2
优先权日:2005-09-30
标题 :Chemical process for the synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline

专利号:US-2014378684-A1
优先权日:2005-09-30
标题 :Chemical Process for the Synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline

专利号:US-8865899-B2
优先权日:2005-09-30
标题:Chemical process for the synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline

专利号:US-2024150317-A1
优先权日:2005-09-30
标题 :Chemical Process for the Synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline