专利号:US-5057633-A 优先权日:1989-11-24 标题 :Synthesis of perfluoroalkyl bromides 发明人:DRIVON GILLES; DURUAL PIERRE; GHENASSIA ELIE 权利人:ATOCHEM 摘要:The invention relates to the preparation of perfluoroalkyl bromides or bromoperfluoroalkanes C n F 2n+1 -Br (n=1 to 20). n A perfluoroalkanesulphonyl chloride C n F 2n+1 -SO 2 Cl is reacted with a compound of formula: ##STR1## in which X represents a nitrogen or phosphorus atom and R 1 , R 2 , R 3 and R 4 , which may be identical or different, each represent an optionally substituted hydrocarbon radical, it also being possible for one of these symbols to be a hydrogen atom.
专利号:US-6958145-B2 优先权日:2000-06-28 标 题:Synthesis of cyclic compounds 发明人:KUMAR NARESH; READ ROGER WAYNE 权利人:UNISEARCH LTD 摘要:A method for the preparation of a compound of formula (II) wherein R 1 and R 2 are independently H, alkyl, alkoxy, oxoalkyl, alkenyl, aryl or arylalkyl whether unsubstituted or substituted, optionally interrupted by one or more hetero atoms, straight chain or branched chain, hydrophilic, hydrophobic or fluorophilic; R 3 , R 4 , R 5 and R 6 are independently or all hydrogen or halogen; provided that at least two of the R 3 , R 4 , R 5 and R 6 are halogens.
专利号:US-6867333-B2 优先权日:2000-10-16 标题:Epothilone synthesis building blocks iii and iv: asymmetrically substituted acyloins and acyloin derivatives, methods for their production and methods for the production of epothilones b, d and epothilone derivatives 发明人:WESSJOHANN LUDGER A; SCHEID GUNTHER; BORNSCHEUER UWE; HENKE ERIK; KUIT WOUTER; ORRU ROMANO 权利人:MORPHOCHEM AG 摘要:The present invention is directed to novel acyloins, their derivatives, methods for their production and their use for the production of novel epothilones and their derivatives. In addition, the invention is directed to the building blocks for epothilone synthesis, methods for their production and the use of synthetic building blocks for the production of epothilones and their derivatives.
专利号:EP-3567040-B1 优先权日:2013-06-24 标 题 :Method for the preparation of intermediates useful for the synthesis of [1,2,4]-triazolo[4,3-a]pyridines
专利号:US-2008214386-A1 优先权日:2004-03-01 标题:Catalyst for Cyclic Carbonate Synthesis 发明人:TAKAHASHI TOSHIKAZU; WATAHIKI TSUTOMU; YASUDA HIROYUKI; SAKAKURA TOSHIYASU 权利人:TAKAHASHI TOSHIKAZU; WATAHIKI TSUTOMU; YASUDA HIROYUKI; SAKAKURA TOSHIYASU 摘要:Provided are a solid catalyst which gives a cyclic carbonate at a high yield and a high selectivity, which is stable and which may be readily separated after reaction; and a method of industrially advantageous, inexpensive and safe production of a cyclic carbonate by the use of the catalyst. The catalyst contains an inorganic solid substance having a surface modified with an ionic substance containing a Group 15 element; or contains an ionic substance containing a Group 15 element, and an inorganic solid substance. The modifying group for surface modification of an inorganic solid substance is an ionic substance containing a Group 15 element. The ionic substance containing a Group 15 element is at least one substance selected from organic phosphonium salts, organic ammonium salts, organic arsonium salts and organic antimonium salts.
专利号:US-4684724-A 优先权日:1981-12-25 标题:4-Cyano-2-azetidinones and production thereof 发明人:OCHIAI MICHIHIKO; KISHIMOTO SHOJI; MATSUO TAISUKE 权利人:TAKEDA CHEMICAL INDUSTRIES LTD 摘要:4-Cyano-2-azetidinone derivatives represented by the formula ##STR1## wherein R 1 is an amino group which may be acylated or protected, X is a hydrogen atom or a methoxy group and W is a hydrogen atom or a sulfo group, and methods of producing the same, for example, as represented by ##STR2## wherein R 2 is an acylated or protected amino group, Y is a halogen atom or a group having the formula --OCOR 3 , --SCOR 3 or --S(O) n --R 3 (R 3 being a hydrocarbyl group and n an integer 1 or 2), R 4 is an amino group which may be acylated or protected and X is as defined above. Compounds [I] are useful as advantageous intermediates for the synthesis of optically active 4-substituted-2-azetidinone derivatives, and, when W=SO 3 H, [I] are also useful as antimicrobial agents and as beta-lactamase inhibitors.
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合成参考文献
摘要:Journal of Pharmacology and Experimental Therapeutics., 99(16), 1950 []