专利号:US-5455157-A 优先权日:1989-05-22 标 题:Method for the non-radioactive measurement of the nucleic acid synthesis in eukaryotic cells 发明人:HINZPETER MATTHIAS; ELTZ HERBERT VON DER 权利人:BOEHRINGER MANNHEIM GMBH 摘要:For the determination of the rate of nucleic acid synthesis in eukaryotic cells a nucleotide which is non-radioactively labelled or derivatized with a hapten is introduced into the cells with the addition of liposomes and the rate of synthesis of the nucleic acids is determined by means of the incorporation of the nucleotide via its label or derivatization.
专利号:US-2023111600-A1 优先权日:2019-12-17 标题 :Polymeric fatty acid compounds for the treatment of fibrous amino acid-based substrates, especially hair 发明人:WAGNER ROLAND; STREICHER KATHARINA; ROHMANN LAURA; WENSKE CHRISTIAN; HAVELI SHRUTISAGAR DATTATRAYA 权利人:MOMENTIVE PERFORMANCE MAT GMBH 摘要:The present invention is directed at mono-, di- or polyquaternary ammonium compounds of the formula (I) wherein x is 1 to 50, and F can be the same or different and is represented by the general formula (II) wherein at least one of the optionally substituted and optionally functional-group-containing hydrocarbon radicals R 1 , R 2 , R 3 , R 4 or R 5 contains at least one estolide moiety comprising two or more ester or amide moieties. The invention also relates to a process for the synthesis of such compounds, the use of the compounds in cosmetic formulations for skin and hair care, cosmetic compositions for the treatment of fibers, and compositions containing one or more of the compounds for the treatment of hair.
专利号:EP-1406599-B1 优先权日:2001-07-07 标 题 :Cosmetic and dermatological preparations containing creatine for treating and actively preventing dry skin and other negative alterations of the physiological homeostasis of healthy skin 发明人:SAUERMANN GERHARD; SCHREINER VOLKER; DOERING THOMAS; SIEFKEN WILFRIED; GATERMAN CORNELIA; CARSTENSEN STEFANIE; BIERGIESSER HELGA; BLATT THOMAS 权利人:BEIERSDORF AG 摘要:Topical compositions containing creatine and its precursors and derivatives, are used to improve skin condition and to treat or prevent skin disorders, abnormal lipid peroxidation, reduced cell-cell communication, deficient intracellular DNA synthesis, DNA damage, deficient DNA repair, abnormal post-translational modification of connective tissue components and dandruff. Topical compositions comprising creatine and its precursors and derivatives and optionally electrolytes, polyols, urea and osmolytes are used: (1) to treat or prevent dry skin, to enhance the barrier function of the skin, for treatment, care and prophylaxis of sensitive skin and/or for treatment and prophylaxis of symptoms of a negative change in the physiological homeostasis of normal skin; (2) to treat or prevent inflammatory skin conditions, atopic eczema, polymorphic photodermatitis, psoriasis, vitiligo and sensitive, itching or irritated skin; (3) to treat or prevent abnormal lipid peroxidation; (4) to treat or prevent abnormal ceramide, lipid and energy metabolism of the skin, abnormal transepidermal water loss, reduced skin hydration and moisture content and altered Natural Moisturizing Factor content; (5) to treat or prevent reduced cell-cell communication, deficient intracellular DNA synthesis, DNA damage, reduced endogenous DNA repair, activation of metalloproteinases and/or other proteases or inhibition of corresponding DNA repair mechanisms and abnormal post-translational modification of connective tissue components; (6) to treat or prevent abnormal skin hyaluronic acid and glucosaminoglycan content; and (7) to treat or prevent dandruff of the hair and scalp and skin aging.
专利号:US-6150403-A 优先权日:1997-10-14 标 题 :Topical compositions for regulating the oily/shiny appearance of skin 发明人:BIEDERMANN KIMBERLY A; SCHUBERT HARRY L; PARRAN JR JOHN J 权利人:PROCTER & GAMBLE 摘要:The present invention relates to methods for inhibiting sebaceous gland activity in mammalian skin comprising administration of a topical composition comprising dehydroacetic acid or pharmaceutically acceptable salts thereof, and a dermatologically-acceptable carrier. The present invention also relates to methods and topical compositions further comprising agents which regulate the oily and/or shiny appearance of skin, and agents which treat acne and related skin disorders in mammalian skin and scalp. Methods of reducing sebum synthesis with the use of dehydroacetic acid, methods of regulating the oily and/or shiny appearance of skin, and methods of treating acne and other skin disorders are also encompassed by the present invention.
专利号:US-2004220137-A1 优先权日:2001-07-07 标 题:Cosmetic and dermatological preparations containing osmolytes for the treatment of and active prevention of dry skin and of other negative alterations in the physiological homeostasis of healthy skin 发明人:SAUERMANN GERHARD 摘要:Use of n a) one or more compounds from the group of osmolytes or precursors and derivatives thereof, n b) optionally one or more compounds from the group of electrolytes and n c) optionally one or more compounds from the group formed by polyols and urea, n in preparations (cosmetics, dermatological preparations) to be applied topically for the treatment and active prevention of dry skin and for strengthening the barrier function of the skin, and for the treatment, care and prophylaxis of sensitive skin and/or for the treatment and prophylaxis of the symptoms of a negative change in the physiological homeostasis of healthy skin, in particular deficient, sensitive or hypoactive skin conditions or n deficient, sensitive or hypoactive conditions of skin appendages, inflamed skin conditions, and of atopic eczema, polymorphous photodermatosis, psoriasis, vitiligo, n sensitive, itching or irritated skin, n changes in normal lipid peroxidation, n a change in the ceramide, lipid and energy metabolism of healthy skin, n a change in the physiological transepidermal water loss, n a reduction in skin hydration and decrease in the moisture content of the skin, n change in the natural moisturizing factor content, n reduction in cell-cell communication, n deficiency symptoms of intracellular DNA synthesis, n DNA damage and reduction in endogenous DNA repair mechanisms, n activation of metalloproteinases and/or other proteases or inhibition of the corresponding endogenous DNA repair mechanisms, n deviations from the normal post-translational modifications of connective tissue constituents, n changes in the normal hyaluronic acid and glucosaminoglycan content of healthy skin, dandruff formation by the hair, flaking of the scalp and skin ageing.
专利号:WO-2009058613-A1 优先权日:2007-11-01 标 题 :Methods for stimulating synthesis of pro-collagen or collagen and hyaluronic acid
摘要:GOSSELIN. CTCP 5TH ED 1984 p.V-387 摘要:SRI. 1994 Directory of Chemical Producers -United States of America. Menlo Park, CA: SRI International, 1994., p. 931 摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118 摘要:Journal of the American College of Toxicology 1(4):143-167, 1982 摘要:International Journal of Toxicology 32(Suppl. 1):59-83, 2013