CAS: 99768-12-4; (4-(Methoxycarbonyl)Phenyl)Boronic Acid

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CAS号67-56-1 甲醇 | CAS号14047-29-1 4-羧基苯硼酸 | CAS号5720-05-8 对甲基苯基硼酸 | CAS号619-44-3 4-碘苯甲酸甲酯 | CAS号18107-18-1 (三甲硅烷)重氮甲烷 | CAS号7664-93-9 硫酸 | CAS号77-78-1 硫酸二甲酯 | CAS号619-42-1 对溴苯甲酸甲酯 | CAS号705254-34-8 4-甲氧羰基苯基三氟硼酸钾 | CAS号109963-61-3 4-[4-(甲氧羰基)苯基]苯甲酸 | CAS号106047-17-0 4-(吡啶-4-基)苯甲酸甲酯 | CAS号105417-32-1 methyl 4-phenyl... | CAS号53355-29-6 4-(5-甲酰基-2-呋喃基)苯甲酸甲酯 | CAS号49742-56-5 4’-甲基[1,1’-联苯]-... | CAS号17595-86-7 4-噻吩-2-硼酸甲酯 | CAS号403-33-8 对氟苯甲酸甲酯 | CAS号171364-80-0 4-甲氧羰基苯硼酸频哪醇酯 | CAS号20442-96-0 Methyl 4-azidob... | CAS号99-76-3 尼泊金甲酯

4-碘苯甲酸甲酯置于双二甲胺基乙基醚,异丙基氯化镁,硼酸三甲酯体系中,用 四氢呋喃 作为反应溶剂,以77%的收率获得产物4-甲氧羰基苯硼酸
参考文献:使用i-Prmgcl-双[2-(n,N-二甲基氨基)乙基]醚络合物对带有敏感官能团的芳族卤化物进行非低温i / Br-Mg交换.
标题:使用i-Prmgcl-双[2-(n,N-二甲基氨基)乙基]醚络合物对带有敏感官能团的芳族卤化物进行非低温i / Br-Mg交换.
摘要:[反应:见正文]在环境温度下,在双[2-(n,N-二甲基氨基)乙基]醚存在下,对带有敏感羧酸酯和氰基的碘代和溴代芳烃与异丙基氯化镁进行选择性卤化物-镁交换,得到相应的格氏试剂.使新形成的反应性格氏试剂与亲电子试剂如硼酸三甲酯反应,以非常好或优异的收率获得产物芳基硼酸.
DOI:10.1021/ol052704P

专利信息

专利号:US-9951095-B2
优先权日:2014-05-16
标 题:Chromium metal organic frameworks and synthesis of metal organic frameworks
发明人：ZHOU HONG-CAI; Liu tian-fu; LIAN XIZHEN; ZOU LANFANG; FENG DAWEI
权利人:TEXAS A & M UNIV SYS
摘要:The present invention relates to monocrystalline metal organic frameworks comprising chromium ions and carboxylate ligands and the use of the same, for example their use for storing a gas. The invention also relates to methods for preparing metal organic frameworks comprising chromium, titanium or iron ions and carboxylate ligands. The methods of the invention allow such metal organic frameworks to be prepared in monocrystalline or polycrystalline forms.

专利号:US-8530689-B2
优先权日:2008-05-05
标 题 :Processes for the preparation of biphenyl compounds
发明人：PERCEC VIRGIL; ROSEN BRAD MATTHEW; WILSON DANIELA A; WILSON CHRISTOPHER J
权利人:PERCEC VIRGIL; ROSEN BRAD MATTHEW; WILSON DANIELA A; WILSON CHRISTOPHER J; UNIV PENNSYLVANIA
摘要:The invention concerns processes for the synthesis of a compound of the formula: wherein: R 1 and R 2 are each, independently, C 1 -C 12 alkyl, CO 2 R 3 , OR 4 , R 5 (OR 6 ), or C 6 -C 18 aryl; R 3 -R 6 are each, independently, C 1 -C 12 alkyl or C 6 -C 12 aryl; and n and m are each, independently, O or an integer from 1-5; said process comprising:—contacting a compound of the formula H0-R 7 -0H with BH 3 and a compound of the formula in the presence of a nickel-containing catalyst to produce a first product, where R 7 is a C 2 -C 12 hydrocarbon group and X is a halogen, OMs or OTs;—contacting the first product in situ with a compound of the formula: in the presence of a nickel-containing catalyst to produce a compound of formula I, where Z is a halogen.

专利号:US-6943254-B2
优先权日:1997-03-07
标 题 :Synthesis of pyrazinyl pyridine-3-sulfonamide compounds
发明人：HOGAN PHILIP JOHN
权利人:ASTRAZENECA UK LTD
摘要:A process for the manufacture of: n n nwherein R is (1-4C)alkyl, carboxyl(1-4C)alkyl or 1,3,4-oxadiazol-2-yl comprises:n (a) reaction of the diazonium salt of 3-amino-2-chloropyridine with thionyl chloride in water and an electron transfer catalyst; (b) reaction with isobutyl-(3-methoxy-5-methylpyrazin-2-yl)carbamate and an alkali metal hydride in inert solvent; and (I) where R is (1-4C)alkyl, carboxy(1-4C)alkyl: (c) reaction with a boronic acid: n n (or an anhydride or ester therof) in the presence of a base and a palladium or nickel catalyst in solvent; and removal of the isobutoxy carbonyl group; or (ii) where R is 1,3,4-oxadiazol-2-yl (c) reaction with 4-methoxycarbonylphenylboronic acid (or an anhydride or ester thereof) with a source fluoride ion under aqueous conditions; (d) removal of the isobutoxycarbonyl protecting group; (e) conversion of the methyl ester group to the hydrazide; and (f) conversion to a 1,3,4-oxadiazol-2-yl moiety.

专利号:US-11767302-B2
优先权日:2020-10-01
标题 :Reagents and methods for tetrazine synthesis
发明人：FOX JOSEPH M; LAMBERT WILLIAM; FANG YINZHI; AM ENDE CHRISTOPHER WILLIAM; MAHAPATRA SUBHAM; XIE YIXIN; WANG CHUANQI
权利人:UNIV DELAWARE
摘要:Disclosed herein are mono- and di-substituted tetrazines and methods of their preparation and converting an oxetanyl ester to a thio-substituted tetrazine, which is then converted to a mono-substituted tetrazine, a di-substituted tetrazine, or a vinylether disubstituted tetrazine.

专利号:US-2008119524-A1
优先权日:2002-08-14
标题 :Prenylation inhibitors containing dimethylcyclobutane and methods of their synthesis and use
发明人：BROWN BRADLEY B; REHDER KENNETH S; STRACHAN JON-PAUL; EAVES JERON H; LOWDEN CHRISTOPHER T
权利人:BROWN BRADLEY B; REHDER KENNETH S; STRACHAN JON-PAUL; EAVES JERON H; LOWDEN CHRISTOPHER T
摘要:The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.

专利号:US-2025270185-A1
优先权日:2024-02-28
标题 :Method for preparation of iptacopan hydrochloride
发明人：ZHANG YIPING; LIU QIAOLING; WU YIHUA; ZHENG XUCHUN
权利人:HANGZHOU CHEMINSPIRE TECH CO LTD
摘要:A synthesis method for iptacopan is provided, which includes the asymmetric addition of compound 1 as the starting material with compound 2 benzyl 4-oxo-3,4-dihydropyridine-1(2H)-carboxylate under the action of a metal catalyst and ligand to obtain intermediate compound 3; then, carbonyl group being enzymatically reduced to obtain compound 4; compound 4 undergoing catalytic conversion from the cyano group to the carboxyl group under the action of a cyano hydrolysis enzyme in a one-pot reaction; subsequently, hydroxy groups completing the ethylation reaction; after palladium hydrogenation, key intermediate compound 6 of iptacopan being obtained; finally, compounds 6 and 7 undergoing reduction amination condensation, followed by removing the Boc group to form the target product: hydrochloride salt of iptacopan. This method features a simple process route, high yield, and low costs, which is suitable for industrial production.