CAS: 99016-42-9; Alitame Hydrate

该化合物是一种高效的糖替代物.该化合物在高温和酸性条件下表现出极佳的稳定性,适合烤制成品和碳酸饮料.其清洁的,类似糖的口味特征将后塔萨特值降至最低,将其与其他甜料区别开来.亚格朗水合物代谢后不会影响血糖水平,使其适合糖尿病制剂.监管批准情况因地区而异,因此遵守当地准则至关重要.其低使用率确保了工业生产的成本效益.

英文名称Alitame Hydrate
中文名称L-天门冬酰-D-丙氨酰胺
IUPAC名称bis(3-amino-4-oxo-4-((1-oxo-1-((2,2,4,4-tetramethylthietan-3-yl)amino)propan-2-yl)amino)butanoic acid) pentahydrate
其它别名D-Alaninamide, L-.Alpha.-Aspartyl-N-(2,2,4,4-Tetramethyl-3-Thietanyl)-, Hydrate (2:5); Alitanle; Alitame [usan]; Unii-6Ki9M51Jog; 3'-N-[[4-(Acetylamino)Phenyl]Sulfonyl]-3'-N-Demethylazithromycin; Alitame(P); Alitame Hydrate
CAS编号99016-42-9
MFCD编号:MFCD28101485
FDA UNII编号:6KI9M51JOG
分子式:C28H60N6O13S2分子量:752.95
产品CID: 2028834
产品分类食品添加剂 → 甜味剂

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InChIKey: NUFKRGBSZPCGQB-FLBSXDLDSA-N
InChI=1S/2C14H25N3O4S.5H2O/c2*1-7(16-11(21)8(15)6-9(18)19)10(20)17-12-13(2,3)22-14(12,4)5;;;;;/h2*7-8,12H,6,15H2,1-5H3,(H,16,21)(H,17,20)(H,18,19);5*1H2
计算化学: 氢键受体数*氢键供体数*可旋转键数*

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UN编号NONH for all modes of transport

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专利信息

专利号:US-2017204442-A1
优先权日:2014-05-29
标题 :Enzymatic synthesis of soluble glucan fiber
发明人：DICOSIMO ROBERT; CHENG QIONG; ELIOT ANDREW C; OUWEHAND ARTHUR; PAYNE MARK S; YOU ZHENG
权利人:DU PONT
摘要:An enzymatically produced soluble Î±-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble Î±-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble Î±-glucan fiber are also provided.

专利号:US-10907185-B2
优先权日:2014-05-29
标题 :Enzymatic synthesis of soluble glucan fiber
发明人：CHENG QIONG; DICOSIMO ROBERT; OUWEHAND ARTHUR; YOU ZHENG; LAI JIAN PING; YU ZHEYONG; ZHANG ZHENGHONG
权利人:DUPONT IND BIOSCIENCES USA LLC
摘要:An enzymatically produced soluble Î±-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble Î±-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble Î±-glucan fiber are also provided.

专利号:WO-2005020930-A3
优先权日:2003-09-02
标题 :Improved syntheses of alitame
发明人：KNOBLOCK KEN; SHAH PANKAJ
权利人:KNOBLOCK KEN; SHAH PANKAJ
摘要:The present invention relates to an improved synthesis of alitame (3-L-alpha-aspartyl-D-alanylamido-2,2,4,4-tetramethylthietanylamine) in which residual iodine species formed during the deodorization step are eliminated, resulting in an improved yield and a purer, more consistent product.

专利号:US-2017198323-A1
优先权日:2014-05-29
标题:Enzymatic synthesis of soluble glucan fiber
发明人：CHENG QIONG; DICOSIMO ROBERT; OUWEHAND ARTHUR; YOU ZHENG; PAYNE MARK S; PRASAD JAHNAVI CHANDRA
权利人:DU PONT
摘要:An enzymatically produced soluble Î±-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble Î±-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble Î±-glucan fiber are also provided.

专利号:US-2017198322-A1
优先权日:2014-05-29
标题:Enzymatic synthesis of soluble glucan fiber
发明人：CHENG QIONG; DICOSIMO ROBERT; ELIOT ANDREW C; OUWEHAND ARTHUR; ROESCH BRIAN MICHAEL; ROTHMAN STEVEN CARY; RUEBLING-JASS KRISTIN; YOU ZHENG
权利人:DU PONT
摘要:An enzymatically produced soluble Î±-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble Î±-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble Î±-glucan fiber are also provided.

专利号:US-12110347-B2
优先权日:2014-05-29
标题:Enzymatic synthesis of soluble glucan fiber
发明人：CHENG QIONG; DICOSIMO ROBERT; OUWEHAND ARTHUR; YOU ZHENG; PAYNE MARK S; LAI JIAN PING; RUEBLING-JASS KRISTIN; ROTHMAN STEVEN CARY
权利人:NUTRITION & BIOSCIENCES USA 4 INC
摘要:An enzymatically produced soluble Î±-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble Î±-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble Î±-glucan fiber are also provided.

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主要参考文献

1: Lakade SS, Zhou Q, Li A, Borrull F, Fontanals N, Marcé RM. Hypercrosslinked particles for the extraction of sweeteners using dispersive solid-phase extraction from environmental samples. J Sep Sci. 2018 Apr;41(7):1618-1624. doi: 10.1002/jssc.201701113. Epub 2018 Jan 25. doi: 10.1016/j.clnesp.2017.01.004. Epub 2017 Feb 4. Review. doi: 10.1007/s00216-014-8355-x. Epub 2014 Dec 4.
4: Chattopadhyay S, Raychaudhuri U, Chakraborty R. Artificial sweeteners - a review. J Food Sci Technol. 2014 Apr;51(4):611-21. doi: 10.1007/s13197-011-0571-1. Epub 2011 Oct 21. Review.
5: Tsuruda S, Sakamoto T, Akaki K. [Simultaneous determination of twelve sweeteners and nine preservatives in foods by solid-phase extraction and LC-MS/MS]. Shokuhin Eiseigaku Zasshi. 2013;54(3):204-12. Japanese. Chinese. doi: 10.1080/19440049.2012.699475. Epub 2012 Jul 24. doi: 10.1007/s00216-011-4937-z. Epub 2011 Apr 5.

合成参考文献

摘要:Lee TD; Kirk-Othmer Encyclopedia of Chemical Technology. (2006). NY, NY: John Wiley & Sons; Sweeteners. Online Posting Date: March 24, 2006
摘要:Rowe, R.C., Sheskey, P.J., Quinn, M.E.; (Eds.), Handbook of Pharmaceutical Excipients 6th edition Pharmaceutical Press, London, England 2009, p. 28