CAS: 98603-84-0; (2S,4S,5R,6R)-5-Acetamido-2-(((2S,3R,4S,5S,6R)-2-(((2R,3R,4R,5R)-5-Acetamido-1,2-Dihydroxy-6-Oxo-4-(((2S,3S,4R,5S,6S)-3,4,5-Trihydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)Hexan-3-yl)Oxy)-3,5-Dihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-4-yl)Oxy)-4-Hydr
该化合物是一种碳水化合物结构,在细胞粘合和识别过程中起着重要作用,特别是在免疫反应和癌症转移过程中,是一种甘油,特别是硅化的烟烟烟,它含有硅酸和烟花残留物,这种化合物经常出现在甘油蛋白和甘油脂表面,它有助于形成介质液球贩运和炎热的精选液浆,而硅酸的存在则产生负电荷,影响其与蛋白质和其他生物分子的相互作用.
- 英文名称(2S,4S,5R,6R)-5-Acetamido-2-(((2S,3R,4S,5S,6R)-2-(((2R,3R,4R,5R)-5-Acetamido-1,2-Dihydroxy-6-Oxo-4-(((2S,3S,4R,5S,6S)-3,4,5-Trihydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)Hexan-3-yl)Oxy)-3,5-Dihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-4-yl)Oxy)-4-Hydr
- 中文名称唾液酸化酶X
- IUPAC名称(2S,4S,5R,6R)-5-acetamido-2-(((2S,3R,4S,5S,6R)-2-(((2R,3R,4R,5R)-5-acetamido-1,2-dihydroxy-6-oxo-4-(((2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)hexan-3-yl)oxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)oxy)-4-hydroxy-6-((1R,2R)-1,2,3-trihydroxypropyl)tetrahydro-2H-pyran-2-carboxylic acid
- 其它别名5-Acetamido-3,5-Di-Deoxy-D-Glycero-Alpha-D-Galacto-2-Noulopyranosyl(2-3)-Beta-D-Galactopyranosyl(1-4)-[alpha-L-Fucopyranosyl(1-4)]-2-Acetamido-2-Deoxy-Beta-D-Glucopyranoside; 3'-Sialyl Lewis; 3'-Sialyl-Lewisx; 3'-Sialyl-Lewis-X Tetrasaccharide; Neu5Ac-Alpha2,3Gal-Beta1,4(Fuc-Alpha1,3)Glcnac; Neu5Ac-Alpha2,3Galbeta1,4(Fucalpha1,3)Glcnac, Sodium Salt; Neunac-Alpha2-3Gal-Beta1-4(Fuc-Alpha1-3)Glcnac; Neu5Ac2-A-3Gal1-B-4[fuc1-A-3]Glcnac
- CAS编号98603-84-0
- MFCD编号:MFCD00270073
- FDA UNII编号:0PS35WG8U3
- 分子式:C31H52N2O23分子量:820.75
- 产品CID: 2027218
- 产品分类生物化工 → 糖类化合物 → 寡糖
物理性质
- 熔点157 - 161°C
- 沸点1285.8 °C at 760mmHg
- 闪点731.4 °C
- 密度1.66g/cm3
- PSA:410.71
- LogP:-8.6034
- 折射率1.653
- 溶解性Methanol (Slightly), Water (Slightly)
- 敏感性Store in freezer
- 外观形态白色至类白色固体
- 储存条件-20°C
- 产品应用该化合物是E-,P-和L-WECTINS(CD62)的高亲和紧合物,它抑制了CD62中导的肺部萎缩剂被吸收到炎热地点;它阻止HL-60细胞和人类肺部营养素被活性小板吸附;含有SLEX的脂质薄膜显示有强大的抗适应活动,显示其亲和性比非硅化的LEWS X (LEX),亲和达到1微克/毫升的最高抑制度高10倍;SLEX的功能是30倍的对肺部支聚变阻力阻力,比LEX的阻力要强,仅需要2微克/升/毫拉,而莱X的54微克/米/毫L,抑制50%;含有SLEX结构抑制通过CD62对活性板捆绑的微粒子的可溶性人类乳胶片.
MSDS等安全信息
合成工艺路线路线简述
专利信息
专利号:US-5866378-A
优先权日:1995-10-06
标 题:Process for the synthesis of nucleotide-6-deoxy-D-xylo-4-hexuloses
发明人：MARQUARDT RUEDIGER; HOERSCH BRIGITTE; SEIFFERT-STOERIKO ANDREAS; STEIN ANDREAS; ZERVOSEN ASTRID; ELLING LOTHAR; KULA MARIA REGINA; VERSECK STEFAN; DISTLER JUERGEN; PIEPERSBERG WOLFGANG
权利人:HOECHST AG
摘要:The present invention relates to processes for the enzymatic synthesis of nucleotide-6-deoxy-D-xylo-4-hexuloses starting from a nucleoside monophosphate (NMP). These processes comprise simultaneous incubation of the following substances in a buffer solution: n (a) substrates comprising a nucleoside monophosphate, phosphoenolpyruvate, adenosine triphosphate, and sucrose; and n (b) enzymes comprising pyruvate kinase, nucleoside-monophosphate kinase, sucrose synthase and deoxythymidine-D-glucose 4,6dehydratase.
专利号:WO-9616071-A1
优先权日:1994-11-21
标题:PROCESSES FOR THE SYNTHESIS OF 3'-SUBSTITUTED LEWISx COMPOUNDS
发明人：SRIVASTAVA OM; IPPOLITO ROBERT; SRIVASTAVA GEETA; SZWEDA ROMAN; OHUCHI TOSHIO
权利人:GLYCOMED INC; SRIVASTAVA OM; IPPOLITO ROBERT; SRIVASTAVA GEETA; SZWEDA ROMAN; OHUCHI TOSHIO
摘要:Disclosed are processes for the chemical synthesis of 3'-substituted Lewis
专利号:US-7655445-B2
优先权日:2003-11-12
标题 :Methods for synthesis of sulfated saccharides
发明人：ROSENBERG ROBERT D; BALAGURUNATHAN KUBERAN
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The present invention provides methods, processes and reaction mixtures, which produce sulfated heparosan polysaccharides. This invention also provides methods and reaction mixtures for the synthesis of N-deacetylate N-sulfate derivatives of non-sulfated N-acetyl heparosan (HS) polysaccharides.
专利号:US-5352670-A
优先权日:1991-06-10
标题:Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides
发明人：VENOT ANDRE P; UNGER FRANK M; KASHEM MOHAMMED A; BIRD PAUL; MAZID M ABDUL
权利人:ALBERTA RES COUNCIL
摘要:Disclosed are methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides. Specifically, in the disclosed methods, sialyltransferase is activated to transfer an analogue of sialic acid, employed as its CMP-nucleotide derivative, to an oligosaccharide glycoside. The analogue of sialic acid and the oligosaccharide employed in this method are selected to be compatible with the sialyltransferase employed.
专利号:US-7223845-B2
优先权日:1998-06-16
标 题:Synthetic glycosulfopeptides and methods of synthesis thereof
发明人：CUMMINGS RICHARD D; MCEVER RODGER P
权利人:UNIV OKLAHOMA
摘要:A new class of synthetic glycosulfopeptides (GSPs) which have one or more sulfated tyrosine residues and a glycan linked to the peptide, the glycan preferably including a sialyl Lewis x group or a sialyl Lewis a group. In a preferred version the GSPs have an O-glycan comprising a β1,6 linkage to a GalNAc. The present invention further contemplates in vitro methods of the synthesis of these GSPs without the use of the cells and methods of their use in vivo as powerful anti-inflammatory antithrombotic, or anti-metastatic compounds. The invention also contemplates a method of synthesizing oligosaccharides by cleaving the glycan from the GSP.
专利号:US-6713287-B1
优先权日:1995-10-24
标 题 :Enzymatic synthesis of L-fucose and L-fucose analogs
发明人：WONG CHI-HUEY
权利人:SCRIPPS RESEARCH INST
摘要:Fucose and fucose analogs are synthesized enzymatically in a three step synthetic protocol. In the first step, L-fuculose-1-phosphate of analog thereof is produced by means of an aldolase catalyzed aldol addition reaction. In the second step, the fuculose-1-phosphate or analog thereof is dephosphorylated to form L-fuculose or an analog thereof using acid dephosphorylase as a catalyst. In the third step, the L-fuculose or analog thereof is converted to L-fucose or an analog thereof using L-fucose isomerase as a catalyst. The synthesis may be a one pot reaction involving the addition substrates and each of the above enzymes to a single reaction vessel. Alternatively, the synthesis may be carried out with purification steps after each reaction.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Polley MJ, Phillips ML, Wayner E, et al. CD62 and endothelial cell-leukocyte adhesion molecule 1 (ELAM-1) recognize the same carbohydrate ligand, sialyl-Lewis x. Proc Natl Acad Sci U S A. 1991;88(14):6224‐6228. doi:10.1073/pnas.88.14.6224.
2: Lasky LA. Selectins: interpreters of cell-specific carbohydrate information during inflammation. Science. 1992;258(5084):964‐969. doi:10.1126/science.1439808.
合成参考文献
参考文献:10.1016/0169-5002(96)00569-7
摘要:Kawai T, Hiroi S, Hanai N, Shitara K. KM195 as an immunohistochemical marker of adenocarcinoma of the lung. Lung Cancer. 1996 Aug;15(1):41–50. doi: 10.1016/0169-5002(96)00569-7.
参考文献:10.1007/bf00336822|10.1111/j.1432-2277.1996.tb00988.x
摘要:Hamarnoto I, Ahossain M, Takashi SM, Maeta MH. Impact of adhesion molecules of the selectin family on liver microcirculation at reperfusion following cold ischemia. Transplant Int. 1996 Sep;9(5):454–60. doi: 10.1111/j.1432-2277.1996.tb00988.x.
参考文献:10.1016/0968-0896(96)00105-8
摘要:Kiyoi T, Nakai Y, Kondo H, Ishida H, Kiso M, Hasegawa A. A highly practical synthesis of the sialyl Lewis X pentasaccharide and an investigation of binding to E-, P-, and L-Selectins. Bioorganic & Medicinal Chemistry. 1996 Aug;4(8):1167–76. doi: 10.1016/0968-0896(96)00105-8.
参考文献:10.1177/172460089901400207
摘要:Yoshimasu T, Maebeya S, Suzuma T, Bessho T, Tanino H, Arimoto J, Sakurai T, Naito Y. Disappearance curves for tumor markers after resection of intrathoracic malignancies. Int J Biol Markers. 1999 Apr;14(2):99–105. doi: 10.1177/172460089901400207.
参考文献:10.1016/s0968-0896(98)00245-4
摘要:Huwe CM, Woltering TJ, Jiricek J, Weitz-Schmidt G, Wong C. Design, synthesis and biological evaluation of aryl-substituted sialyl Lewis X mimetics prepared via cross-metathesis of C-fucopeptides. Bioorganic & Medicinal Chemistry. 1999 May;7(5):773–88. doi: 10.1016/s0968-0896(98)00245-4.
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