CAS: 90878-19-6; Phenethylmagnesium Chloride

该化合物是一种有机磁性化合物,被归类为甘甘地试剂,广泛用于有机合成;其特点是反应性很强,特别是针对电极,使其成为形成碳-碳键的宝贵工具;该化合物一般表现为无色的轻黄色液体或固体,视其形态和纯度而定;在二乙醚和四氢呋喃等有机溶剂中可溶解,但它与水和水分,碳氢化合物释放和形成氢氧化镁发生强烈反应;氯化苯乙酰胺经常用于酒精,氯酮和其他功能组的合成中,通过核脑激素添加反应.由于其反应,该化合物必须在惰性大气中处理,例如氮或丙贡,以防止脱腐蚀和确保安全.此外,必须指出,诸如氯化苯乙酰胺等硫酸等红色剂对空气和水分很敏感,需要实验室环境中谨慎储存和处理.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

合成工艺路线路线简述

  • 3277-89-2 = 90878-19-6 [标题:Reaction Conditions
    标题:Synthesis Of Optically Pure α-Alkylated α-Amino Acids And A Single-Step Method For Enantiomeric Excess Determination
    作者:Kruizinga,Wim H.; Bolster,John; Kellogg,Richard M.; Kamphuis,Johan; Boesten,Wilhelmus H. J.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1988 卷标:53(8) 页码:1826-7]

    622-24-2 = 90878-19-6
    反应条件:1.1 Reagents: Magnesium Solvents: 1-Chloro-1-Methoxypentane; 0.5 H,170 °C; 90 °C; 1.5 H,90 °C; 1 H,Reflux
    标题:Method For Catalytic Enantioselective Alkylation Of Aldehydes Using Grignard Reagents As Alkyl Sources
    作者:Tanaka,Kento; Tomihama,Munehisa; Yamamoto,Koji; Matsubara,Naoki; Harada,Toshiro
    参考文献:Journal Of Organic Chemistry 日期:2018 卷标:83(11) 页码:6127-6132]

    622-24-2 = 90878-19-6
    反应条件:1.1 Reagents: Magnesium,Iodine Solvents: Diethyl Ether; 40 °C; 0 °C; 0 °C -> Rt; 2 H,Rt
    标题:Grignard Reagent Utilization Enables A Practical And Scalable Construction Of 3-Substituted 5-Chloro-1,6-Naphthyridin-4-One Derivatives
    作者:Wang,Ming-Shu; Gong,Yi; Yu,Zhi-Cheng; Tian,Yan-Guang; Zhuo,Lin-Sheng; Et Al
    参考文献:Molecules 日期:2020 卷标:25(23)]

    622-24-2 = 90878-19-6
    反应条件:1.1 Reagents: Magnesium Solvents: Diethyl Ether; Rt -> Reflux; 15 Min,Reflux
    标题:Standardization And Control Of Grignard Reactions In A Universal Chemical Synthesis Machine Using Online Nmr
    作者:Bornemann-Pfeiffer,Martin; Wolf,Jakob; Meyer,Klas; Kern,Simon; Angelone,Davide; Et Al
    参考文献:Angewandte Chemie 日期:2021 卷标:60(43) 页码:23202-23206]

    622-24-2 = 90878-19-6
    反应条件:1.1 Reagents: Magnesium,Iodine Solvents: Tetrahydrofuran
    标题:Formyl Transfer To Grignard Reagents With N-Formylpiperidine: 3-Phenylpropionaldehyde
    作者:Olah,George A.; Arvanaghi,Massoud
    参考文献:Organic Syntheses 日期:1986 卷标:64 页码:114-17

海关参考信息

专利信息


专利号:US-7432285-B2
优先权日:1999-12-23
标 题 :Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
发明人：BANDARAGE RAMANI R; BANDARAGE UPUL K; FANG XINQIN; GARVEY DAVID S; LETTS L GORDON; SCHROEDER JOSEPH D; TAM SANG W
权利人:NITROMED INC
摘要:The present invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or optionally, at least one therapeutic agent. The present invention also provides novel compositions comprising at least one parent COX-2 inhibitor and at least one nitric oxide donor, and, optionally, at least one therapeutic agent. The present invention also provides kits and methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 inhibitors; for facilitating wound healing; for treating and/or preventing renal toxicity; and for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2.

专利号:US-2010184989-A1
优先权日:2007-03-12
标 题 :De Novo Synthesis of Conjugates
发明人：RIGGS-SAUTHIER JENNIFER; DENG BO-LIANG; REN ZHONGXU; ZHANG WEN; GU XUYUAN; DUARTE FRANCO J
权利人:NEKTAR THERAPEUTICS
摘要:The invention provides methods for the preparation of small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a water-soluble oligomer composition. Such drugs are produced through modification of a synthetic pathway to attach the oligomer to an intermediate compound followed by completion of the synthetic path.

专利号:AU-2008226820-A1
优先权日:2007-03-12
标题 :De novo synthesis of conjugates

专利号:CA-2679473-A1
优先权日:2007-03-12
标题:De novo synthesis of conjugates

专利号:EP-2125027-A2
优先权日:2007-03-12
标题:De novo synthesis of conjugates

专利号:WO-2008112286-A2
优先权日:2007-03-12
标题:De novo synthesis of conjugates

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合成参考文献


摘要:Eilbracht, P., Science of Synthesis, (2009) 48, 394.
摘要:Kantchev, E. A. B.; Organ, M. G., Science of Synthesis, (2009) 48, 38.
摘要:Molander, G. A.; Beaumard, F., Science of Synthesis Knowledge Updates, (2013) 3, 119.
摘要:Song, Z.; Takahashi, T., Science of Synthesis Knowledge Updates, (2013) 1, 107.
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