CAS: 86329-79-5; Sodium (6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(Methoxyimino)Acetamido)-3-(((5-(Carboxylatomethyl)-4-Methylthiazol-2-yl)Thio)Methyl)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate

• 英文名称Sodium (6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(Methoxyimino)Acetamido)-3-(((5-(Carboxylatomethyl)-4-Methylthiazol-2-yl)Thio)Methyl)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate
• 中文名称头孢地嗪钠
• IUPAC名称sodium (6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(((5-(carboxylatomethyl)-4-methylthiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• 其它别名Cefodizime disodium; Kenicef; 7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(((5-(carboxymethyl)-4-methyl-2-thiazolyl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)°Ct-2-ene-2-carboxylic acid
• CAS编号86329-79-5
• MFCD编号:MFCD00897059
• EINECS号:617-833-6
• FDA UNII编号:HC1T51593A
• 分子式:C20H18N6Na2O7S4
• 分子量:628.65
• 产品CID: 1864452
• 产品分类原料药 → 抗生素类药物 → 头孢菌素类药

• 相似结构搜索
• InChIKey: WBOBLQIRACJNPA-AEKYOGSZSA-L
• LTIUKZADMUEHDC-LJYFWBPINA-N…
• 计算化学: 氢键受体数15.0氢键供体数2.0可旋转键数8.0

物理性质

• 熔点196 - 207°C
• PSA:310.14
• LogP:-0.7607
• 溶解性DMSO (Slightly), Methanol (Sparingly)
• 外观形态白色至类白色粉末
• 储存条件2-8°C
• 产品应用该化合物是第三代甲状腺素抗生素抗生物,其抗氧基克阳性和负微克细菌的活动范围广泛.

MSDS等安全信息

• GHS象形图
• GHS符号GHS08;
  注释: Health hazard
• 危险类别呼吸道致敏 类别1
  皮肤致敏 类别1
  严重眼刺激 类别2
• 警示词Danger(危险)
• 危险描述H334 |吸入可能引起过敏或哮喘症状或呼吸困难.
  H317 |可能引起皮肤过敏反应.
  H319 |造成严重眼刺激.
• 防范说明P305+P351+P338

欧盟法规

上下游产品

合成工艺路线路线简述

• 80756-85-0 + 111298-82-9 = 86329-79-5
  反应条件:1.1 Reagents: Hexamethyldisilazane Solvents: Dichloromethane; 6 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 3.52.1 Reagents: Triethylamine Solvents: Ethanol,Water; 15 - 20 °C2.2 Reagents: Sodium 2-Ethylhexanoate Solvents: Water; Ph 8.0; 2.5 H
  标题:Synthesis Of Cefodizime Disodium
  作者:Li,Mingjie; Et Al
  参考文献:Zhongguo Yiyao Gongye Zazhi 日期:2013 卷标:44(11) 页码:1089-1090]
  
  69739-16-8 = 86329-79-5
  反应条件:1.1 Reagents: Triethylamine Solvents: Ethanol,Water; 15 - 20 °C1.2 Reagents: Sodium 2-Ethylhexanoate Solvents: Water; Ph 8.0; 2.5 H
  标题:Synthesis Of Cefodizime Disodium
  作者:Li,Mingjie; Et Al
  参考文献:Zhongguo Yiyao Gongye Zazhi 日期:2013 卷标:44(11) 页码:1089-1090]
  
  80756-85-0 + 111298-82-9 = 86329-79-5
  反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane
  标题:Method Of Isolating Polybasic Aminothiazolyl β-Lactam Antibiotics In The Form Of High-Purity Sodium Salts
  参考文献:Poland]
  
  = 86329-79-5
  反应条件:1.1 Reagents: Triethylamine Solvents: Water; 5 °C1.2 30 Min,5 °C1.3 Reagents: Isooctanoic Acid,Sodium Salt Solvents: Acetone; 1 H,5 °C; 2 H,5 °C
  标题:Synthesis Of Cefodizime Disodium
  作者:Li,Aijun; Et Al
  参考文献:Zhongguo Kangshengsu Zazhi 日期:2005 卷标:30(6) 页码:332-335]
  
  34272-64-5 + 63527-52-6 = 86329-79-5
  反应条件:1.1 Reagents: Sodium Carbonate Solvents: Acetone,Water; Rt; Rt -> 60 °C; 55 - 60 °C1.2 Reagents: Potassium Carbonate Solvents: Water; Ph 6.5,55 - 60 °C; 4 H,55 - 60 °C1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 5.5,55 - 60 °C1.4 30 Min,55 - 60 °C; 60 °C -> 20 °C; 20 °C -> 5 °C1.5 Reagents: Hydrochloric Acid Solvents: Water; Ph 5.0,5 °C1.6 Reagents: Hydrochloric Acid Solvents: Water; Ph 3.0,5 °C; 1 H,5 °C2.1 Reagents: Triethylamine Solvents: Water; 5 °C2.2 30 Min,5 °C2.3 Reagents: Isooctanoic Acid,Sodium Salt Solvents: Acetone; 1 H,5 °C; 2 H,5 °C
  标题:Synthesis Of Cefodizime Disodium
  作者:Li,Aijun; Et Al
  参考文献:Zhongguo Kangshengsu Zazhi 日期:2005 卷标:30(6) 页码:332-335]
  
  34272-64-5 + 957-68-6 = 86329-79-5
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; Ph 6.5; 2.5 H,Rt -> 80 °C; 80 °C -> 30 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 3.8; 1 H2.1 Reagents: Hexamethyldisilazane Solvents: Dichloromethane; 6 H,Rt2.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 3.53.1 Reagents: Triethylamine Solvents: Ethanol,Water; 15 - 20 °C3.2 Reagents: Sodium 2-Ethylhexanoate Solvents: Water; Ph 8.0; 2.5 H
  标题:Synthesis Of Cefodizime Disodium
  作者:Li,Mingjie; Et Al
  参考文献:Zhongguo Yiyao Gongye Zazhi 日期:2013 卷标:44(11) 页码:1089-1090]
  
  34272-64-5 + 957-68-6 = 86329-79-5
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 2 H,Ph 6.5,Rt -> 80 °C; 80 °C -> 30 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; 1 H,Ph 3.82.1 Reagents: Hexamethyldisilazane Solvents: Dichloromethane; 6 H,Rt2.2 Reagents: Hydrochloric Acid; Ph 3.53.1 Reagents: Triethylamine,Sodium 2-Ethylhexanoate Solvents: Ethanol,Water; 15 - 20 °C; 2.5 H,Ph 8,15 - 20 °C
  标题:Synthesis Of Cefodizime Sodium
  作者:Li,Aijun; Et Al
  参考文献:Zhongguo Kangshengsu Zazhi 日期:2010 卷标:35(11) 页码:845-847]
  
  80756-85-0 + 957-68-6 = 86329-79-5
  反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; Rt -> 5 °C; 5 °C1.2 4 H,5 °C1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 51.4 30 Min,Rt; Rt -> 5 °C1.5 Reagents: Hydrochloric Acid Solvents: Water; Ph 2.5,5 °C; 1 H,5 °C2.1 Reagents: Sodium Carbonate Solvents: Acetone,Water; Rt; Rt -> 60 °C; 55 - 60 °C2.2 Reagents: Potassium Carbonate Solvents: Water; Ph 6.5,55 - 60 °C; 4 H,55 - 60 °C2.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 5.5,55 - 60 °C2.4 30 Min,55 - 60 °C; 60 °C -> 20 °C; 20 °C -> 5 °C2.5 Reagents: Hydrochloric Acid Solvents: Water; Ph 5.0,5 °C2.6 Reagents: Hydrochloric Acid Solvents: Water; Ph 3.0,5 °C; 1 H,5 °C3.1 Reagents: Triethylamine Solvents: Water; 5 °C3.2 30 Min,5 °C3.3 Reagents: Isooctanoic Acid,Sodium Salt Solvents: Acetone; 1 H,5 °C; 2 H,5 °C
  标题:Synthesis Of Cefodizime Disodium
  作者:Li,Aijun; Et Al
  参考文献:Zhongguo Kangshengsu Zazhi 日期:2005 卷标:30(6) 页码:332-335

海关参考信息

• 2901210000-乙烯
  2901220000-丙烯
  2912110000-甲醛
  2912120000-乙醛
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• 详情请参考：📖 海关编码查询和海关进出口税则

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
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• ➥ REACH监管