CAS: 78919-13-8; (E)-5-((3As,4R,5R,6As)-5-Hydroxy-4-((3S,E)-3-Hydroxy-4-Methyloct-1-En-6-Yn-1-yl)Hexahydropentalen-2(1H)-Ylidene)Pentanoic Acid

上下游产品

CAS号101314-49-2 Methyl (1S,5S,6... | CAS号70073-58-4 3-甲基-2-氧代-5-乙炔基... | CAS号79812-95-6 (3aS,4R,5R,6aR)...

📜在 Manganese(Iv) Oxide,2,6-二叔丁基-4-甲基苯酚,水,二异丁基氢化铝,Sodium Hydroxide体系中,用 四氢呋喃,乙酸乙酯,甲苯 作为反应溶剂,化学反应生成 伊洛前列素
参考文献: Process For The Preparation Of Iloprost[fr] Procédé De Préparation D'Iloprost
标题: Process For The Preparation Of Iloprost[fr] Procédé De Préparation D'Iloprost

专利信息

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-4964846-A
优先权日:1986-05-16
标 题 :Process for the E/Z stereoselective synthesis of homochiral five and six ring intermediate products
发明人：GAIS HANS-JOACHIM; ERDELMEIER IRENE; BIRK ROLF
权利人:SCHERING AG
摘要:This invention comprises a process for the production of unsymmetrical olefins from prochiral symmetrical ketones by addition of lithiosulfoximine from n-butyllithium and N-substituted S-methyl-S-phenyl-sulfoximine derivatives and then reaction with n-butyllithium/trimethychlorosilane.

专利号:US-8183409-B2
优先权日:2004-05-06
标题:High yield and rapid synthesis methods for producing metallo-organic salts
发明人：CHRISTGAU STEPHAN; ANDERSEN JENS E T
权利人:CHRISTGAU STEPHAN; ANDERSEN JENS E T; OSTEOLOGIX AS
摘要:A new method for preparing salts of metal cations and organic acids, especially divalent salts of alkaline earth metal ions from group II of the periodic system and carboxylic acids. The method comprising the use of a high temperature (about 90° or more) and, optionally. high pressure, in order to obtain a higher yield, purity and faster reaction speed than obtained with known synthesis methods. In particular, the present invention relates to the production of strontium salts of carboxylic acids. Novel strontium salts are also provided by the present method.

专利号:US-6653345-B2
优先权日:1997-09-16
标题 :C-C chemokine synthesis inhibitor
发明人：KURUMATANI HAJIMU; SASAKI RIE; KUMAGAI HIROKI
权利人:TORAY INDUSTRIES
摘要:A method of inhibiting mammalian C-C chemokine production by using a mammalian C-C chemokine synthesis inhibitor containing a prostaglandin I derivative as an active component to treat a variety of circulatory diseases, inflammation, allergic diseases, and renal diseases.

专利号:US-2014114086-A1
优先权日:2012-10-22
标 题:Clinprost, Isocarbacyclin And Analogs Thereof And Methods Of Making The Same
发明人：CROATT MITCHELL
权利人:UNIV NORTH CAROLINA AT GREENSBORO
摘要:In one aspect, methods of synthesizing clinprost, isocarbacyclin and analogs thereof are described herein which, in some embodiments, permit an abbreviated synthetic pathway in comparison to one or more prior synthetic methods. By providing a compact synthetic scheme, methods described herein can reduce cost, waste and time of clinprost and isocarbacyclin synthesis while facilitating the development and investigation of analogs of these compounds.