CAS: 690264-39-2; 4-Bromo-2-(Trifluoromethoxy)Phenol

该化合物是一种有机化合物,其特点是含有一种含有一种溴原子和三氟甲基苯氧化合物的苯酚结构,含有一种溴原子和一种三氟甲基苯氧化合物组;在准方位和在正方位的三氟甲基苯氧基组的存在对其化学特性,包括其再活性和溶性有重大影响;该化合物一般在室温下是固体,由于三氟氧基组的电阴性氟辛醇原子,可能会表现出中度至高度的极极分性;它有可能溶于极地有机溶剂,在水中可能具有有限的溶性;三氟氧氧基化合物组可增强化合物的稳定性和亲脂性,使其对各种应用,包括制药和农用化学品感兴趣;此外,该化合物可能展示生物活动,可在药用化学中加以探索;在处理时,应参考安全数据,因为卤化合物可能对环境和健康构成风险.

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2-(trifluoromethoxy)phenol 4-bromo-1-methoxy-2-(trifluoromethoxy)benzene 4-methoxy-3-(trifluoromethoxy)-benzoic acid 4-allyloxy-3-trifluoromethoxybenzoic acid 4-(3'-methyl-2'-butenyloxy)-3-trifluoromethoxybenzoic acid

合成工艺路线路线简述

    📜2-(三氟甲氧基)苯酚置于溴,三氟乙酸体系中,化学反应生成 4-溴-2-(三氟甲氧基)苯酚
    参考文献:P-Hydroxyphenacyl Photoremovable Protecting Groups-Robust Photochemistry Despite Substituent Diversity
    标题:P-Hydroxyphenacyl Photoremovable Protecting Groups-Robust Photochemistry Despite Substituent Diversity
    摘要:一项关于各种取代基对对羟基苯乙酯光化学重排影响的广泛研究表明,常见取代基(如 F,Meo,Cn,Co2R,Conh2 和 Ch3)对光-Favorskii 重排和酸离去基团释放的速率和量子效率影响很小,对反应三重态的寿命影响也很小.当光解在缓冲水介质中进行时,Ph 值超过发色团的基态 Pkao(其中共轭碱是主要形式),则释放和重排的量子产率在所有取代基中都会降低.否则,取代基对这些坚固发色团的光反应影响很小.
    DOI:10.1139/v10-143

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    专利信息


    专利号:US-7691843-B2
    优先权日:2002-07-11
    标 题 :N-hydroxyamide derivatives possessing antibacterial activity
    发明人：RAJU BORE G; O'DOWD HARDWIN; GAO HONGWU; PATEL DINESH V; TRIAS JAOQUIM
    权利人:PFIZER
    摘要:Novel N-hydroxyamide derivatives are disclosed. These N-hydroxyamide derivatives inhibit UPD-3-O—(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, an enzyme present in gram negative bacteria and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.

    专利号:US-9856241-B2
    优先权日:2013-07-03
    标 题:Substituted benzofuranyl and benzoxazolyl compounds and uses thereof
    发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
    权利人:KARYOPHARM THERAPEUTICS INC
    摘要:The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula (A), or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.

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    参考DOI号:10.1021/jm010579r
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