CAS: 6610-25-9; Sodium (5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-Tetraenoate

该化合物是丙烯酸的钠盐衍生物,一种多饱和聚氨酯-6脂肪酸,该化合物的特点是5,8,11,11和14个位置有四支双链,有助于其结构特性和反应性.钠盐形式增强了水溶液的溶性,便于其在生物化学和制药研究中使用.它作为包括丙烯菊酯和脂类生物合成物在内的乙酰胺类动物的主要前体,对研究煽动性和信号路径很有价值.它的高度纯度和稳定性确保了实验应用的可靠性,特别是在细胞培养和酶学研究中的可靠性能.

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    专利信息


    专利号:US-5043328-A
    优先权日:1986-05-09
    标 题 :Formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems
    发明人:WEITHMANN KLAUS U
    权利人:HOECHST AG
    摘要:The present invention relates to formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems and to the use of such formulations for the preparation of medicaments which are suitable for curing prostaglandin deficiencies in humans or animal, for example healing or preventing diseases of the gastro-intestinal tract.

    专利号:US-4777257-A
    优先权日:1983-08-25
    标题:Certain tetrahydronaphthyl or indanylcarboxylates and derivatives thereof which inhibit the synthesis of thromboxane
    发明人:KANAO MUNEFUMI
    权利人:DAIICHI SEIYAKU CO
    摘要:Benzocycloalkane derivatives of the formula (I) ##STR1## wherein: Z represents a methylene group or an ethylene group, either one of R 1 and R 2 represents --(CH 2 ) m --COOR 3 and the other represents ##STR2## wherein R 3 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, n represents an interger of 1 to 6 and m represents an interger of 0 to 5, and the physiologically acceptable salts thereof; having a strong and selective inhibition activity of thromboxane A 2 synthesis.

    专利号:US-4129648-A
    优先权日:1977-11-21
    标 题 :Method for reducing endogenous prostaglandin synthesis
    发明人:COLLIER HARRY O J; SAEED SHEIKH A; SCHNEIDER CYRIL; MANNUZZA FRANK
    权利人:COLLIER HARRY O J; SAEED SHEIKH A; SCHNEIDER CYRIL; MANNUZZA FRANK
    摘要:A high molecular weight extract of mammalian blood plasma and serum proteins of the group Cohn fraction IV, Cohn subfraction IV1, IV4 and haptoglobin, have been found to contain activity which inhibits endogenous prostaglandin synthetase. This extract is therefore of utility in treating or alleviating pathological conditions associated with excessive or unbalanced snythesis of endogenous prostaglandins, for example, in reducing bronchoconstriction or treating arthritis. For this purpose, the extract may be administered by injection, by inhalation, or topically.

    专利号:EP-0244832-B1
    优先权日:1986-05-09
    标 题 :Preparations containing insaturated fatty acids for the synthesis of prostaglandins and of fatty hydroxy acids in biological systems

    专利号:IL-82459-A
    优先权日:1986-05-09
    标 题 :Stabilized pharmaceutical preparations containing polyunsaturated fatty acids and stimulating the synthesis of prostaglandins and hydroxy- and fatty acids in B systems

    专利号:DE-3615710-A1
    优先权日:1986-05-09
    标 题:PREPARATIONS FOR THE SYNTHESIS OF PROSTAGLANDINES AND HYDROXY FATTY ACIDS IN BIOLOGICAL SYSTEMS

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Journal of Pharmacology and Experimental Therapeutics., 224(369), 1983 []
    摘要:Thrombosis Research., 9(67), 1976 []
    参考文献:10.1007/s11418-020-01439-0
    摘要:Yang L, Kirikoshi J, Sato D, Takasugi M, Hishida A, Hayashi S, Kawahara N, Mizukami M, Wu M, Yamagishi T, Arai H. New isoflavone glucosides in yabumame (Amphicarpaea bracteata (L.) Fernald subsp. edgeworthii (Benth.) H.Ohashi var. japonica (Oliv.) H.Ohashi) and their effect on leukotriene B4 production in mast cells. Journal of Natural Medicines. 2020 Aug 16;75(1):28–36. doi: 10.1007/s11418-020-01439-0.
    参考文献:10.1007/bf00504872
    摘要:Prosdocimi M, Zatta A, Gorio A, Zanetti A, Dejana E. Action of AD6 (8-monochloro-3-beta-diethylaminoethyl-4-methyl-7-ethoxycarbonylmet hox y coumarin) on human platelets in vitro. Naunyn Schmiedebergs Arch Pharmacol. 1986 Mar;332(3):305–10. doi: 10.1007/bf00504872.
    参考文献:10.1007/bf01964968
    摘要:Lanza F, Cazenave JP, Beretz A, Sutter-Bay A, Kretz JG, Kieny R. Potentiation by adrenaline of human platelet activation and the inhibition by the alpha-adrenergic antagonist nicergoline of platelet adhesion, secretion and aggregation. Agents Actions. 1986 Aug;18(5-6):586–95. doi: 10.1007/bf01964968.
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