CAS: 50448-95-8; 2-Ethylhexyl 3-Mercaptopropanoate

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7659-86-1 29806-73-3 63321-70-0

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CAS号104-76-7 2-乙基己醇 | CAS号107-96-0 3-巯基丙酸 | CAS号881664-08-0 2-ethylhexyl 3-...

📜2-乙基己醇,3-巯基丙酸置于磷酸体系中,用 甲苯 作为反应溶剂,化学反应生成 3-巯基丙酸-2-乙己酯
参考文献:艾伦化学.八.硫醇化合物与丙二烯的二加成反应
标题:艾伦化学.八.硫醇化合物与丙二烯的二加成反应
摘要:研究了简单的脂肪族和芳香族硫醇,硫羟乙酸,二烷基二硫代磷酸(二硫代磷酸),2-巯基乙醇,巯基乙酸,2-巯基丙酸及其酯与丙二烯的自由基型加成反应.一般而言,发现这种二加成比已知的用于大规模合成三亚甲基双硫醚化合物(末端二加成的产物)的复分解反应更好.各种类型的硫醇化合物对丙二烯的反应性差异很大.叔丁烷和苯硫醇加成数据的比较表明,通常单加成的支化二加合物的量与硫醇的供氢能力成正比,并且形成的烯丙基单加合物的量与硫自由基的稳定性成正比.
DOI:10.1139/v67-196

专利信息

专利号:US-2024239799-A1
优先权日:2021-04-02
标 题:(s)-1-(5-((pyridin-3-yl)thio)pyrazin-2-yl)-4'h,6'h-spiro[piperidine-4,5'-pyrrolo [1,2-b]pyrazol]-4'-amine derivatives and similar compounds as shp2 inhibitors for the treatment of e.g. cancer
发明人：DI FABIO ROMANO; MONTALBETTI CHRISTIAN; PETROCCHI ALESSIA; GRILLO ALESSANDRO; RANDAZZO PIETRO; ROSSETTI ILARIA; CIAMMAICHELLA ALINA
权利人:C N C C S S C A R L COLLEZIONE NAZ DEI COMPOSTI CHIMICI E CENTRO SCREENING; IRBM S P A
摘要:The present invention relates to compounds of formula (I). The compounds of the formula (I) are e.g. (S)-1-(5-((pyridin-3-yl)thio) pyrazin-2-yl)-41H,6′H-spiro[piperidine-4,5′-pyrrolo[1,2-b]pyrazol]-41-amine derivatives and similar compounds. The present invention also relates to the compounds of formula (I) for use as Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitors in methods of treatment of e.g. cancer, cardiovascular diseases, immunological disorders, autoimmune disorders, fibrosis, ocular disorders, systemic lupus erythematosus, diabetes, neutropenia, and combinations thereof. The present invention also relates to pharmaceutical compositions containing said compounds and to their methods of synthesis.

专利号:US-7977371-B2
优先权日:2007-02-26
标题 :Pyrrole derivative having ureido group and aminocarbonyl group as substituents
发明人：KAWASHIMA KENJI; ENOMOTO HIROSHI; ISHIZAKA NORIKO; YAMAMOTO MINORU; KUDOU KAZUHIRO; MURAI MASAAKI; INABA TAKAAKI; OKAMOTO KAZUYOSHI
权利人:SANTEN PHARMACEUTICAL CO LTD
摘要:Objects of the present invention are to study on the synthesis of a novel pyrrole derivative having a ureido group and an aminocarbonyl group as substituents or a salt thereof, to find a pharmacological effect of the derivative or a salt thereof, and to find a medicinal agent which has a prophylactic and/or therapeutic effect on a retinal disease or the like through oral administration. A compound represented by the general formula (1) or a salt thereof has an inhibitory activity against the production of interleukin-6 and/or an inhibitory effect on choroidal neovascularization, and is therefore useful as a prophylactic and/or therapeutic agent for a disease associated with interleukin-6, an ocular inflammatory disease and/or a retinal disease. In the formula, the ring A represents a benzene ring or the like; R 1 represents a halogen atom, a hydrogen atom, a lower alkyl group or the like; R 2 represents a halogen atom, a lower alkyl group which may have a substituent, a lower alkenyl group, a lower alkynyl group which may have a substituent, a lower cycloalkyl group, an aryl group, a hydroxy group, a lower alkoxy group which may have a substituent or the like; and n represents 0, 1, 2, 3 or the like.

专利号:US-8933184-B2
优先权日:2010-07-27
标 题 :Synthesis method of polycarboxylic acid water-reducing agent
发明人：FANG JIAN
权利人:FANG JIAN; SHANGHAI TAIJIE CHEMICAL CO LTD
摘要:A method for synthesizing concrete polycarboxylic acid water-reducing agent at room temperature under non-stirring situation is disclosed, which comprises dissolving reactive materials, initiator, chain transfer agent and promoter into a solvent, reacting on standing at 0-50° C.; then adding neutralizing agent at the end of reaction. The method makes use of oxidation-reduction system reacting at low temperature, and can adapt to a variety of reactive material monomers. It does not need to control feeding speed or provide extra heating, does not need to stir during the reaction, and remarkably simplifies operation steps in traditional process, which makes it possible to not only produce in large scale, but also produce in small scale in concrete construction site at any moment.

专利号:US-2013172505-A1
优先权日:2010-07-27
标 题 :Synthesis method of polycarboxylic acid water-reducing agent

专利号:WO-2024068976-A1
优先权日:2022-09-29
标 题 :Azole derivatives as shp2 inhibitors
发明人：PETROCCHI ALESSIA; MONTALBETTI CHRISTIAN; DI FABIO ROMANO; CIAMMAICHELLA ALINA; ROSSETTI ILARIA
权利人:IRBM S P A; C N C C S S C A R L COLLEZIONE NAZ DEI COMPOSTI CHIMICI E CENTRO SCREENING
摘要:The present invention relates to new compounds capable of inhibiting the activity of SHP2 phosphatase. Compounds of the invention can be used for the treatment of disorders associated with SHP2 deregulation. The present invention also relates to pharmaceutical compositions containing said compounds and to their method of synthesis.

专利号:EP-2599807-A1
优先权日:2010-07-27
标 题:Synthesis method of polycarboxylic acid water-reducing agent