CAS: 47562-08-3; 17-Monochloroacetylajmaline

该化合物是一种化学化合物,属于被称为抗脊髓灰质炎的药物类别,主要用于抗脑膜炎特性,通过阻塞体内引起过敏症状的一种物质,帮助减轻过敏反应;Loramine的特征是能够跨越血液脑屏障,可能导致镇静作用,使其在过敏之外还有助于治疗失眠或焦虑等病症;该化合物一般在有机溶剂中表现出中等溶性,并视环境条件(如pH)和温度(pH)而具有不同稳定性;许多药物,安全情况,潜在副作用以及与其他药物的相互作用都是使用中的重要考虑因素;

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      专利信息


      专利号:US-10925977-B2
      优先权日:2006-10-05
      标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
      发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
      权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
      摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

      专利号:AU-2007308022-A2
      优先权日:2006-10-05
      标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

      专利号:AU-2007308022-A1
      优先权日:2006-10-05
      标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

      专利号:US-2008107598-A1
      优先权日:2006-10-05
      标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications

      专利号:AU-2007308022-B2
      优先权日:2006-10-05
      标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

      专利号:CA-2664826-C
      优先权日:2006-10-05
      标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

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      主要参考文献


      1: Padrini R, Piovan D, Gaglione E, Zordan R, Ferrari M. Determination of lorajmine and its metabolite ajmaline in plasma and urine by a new high-performance liquid chromatographic method. Ther Drug Monit. 1992 Oct;14(5):391-6. Italian. Italian.

      合成参考文献


      摘要:Errichiello G, Maglione S. [Preliminary clinical studies on the antiparkinson effects of 17-monochloroacetylajmaline]. Minerva Med. 1974 May 30;65(41):2357–9.
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