CAS: 40851-95-4; 6-Chloropyridine-2,3-Diamine

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上下游产品

CAS号27048-04-0 2-氨基-3-硝基-6-氯吡啶 | CAS号75-65-0 叔丁醇 | CAS号16013-85-7 2,6-二氯-3-硝基吡啶 | CAS号139086-97-8 N-(6-氯-3-硝基吡啶-2... | CAS号139086-98-9 2-acetamido-3-a... | CAS号4214-75-9 2-氨基-3-硝基吡啶 | CAS号7647-01-0 盐酸 | CAS号40851-98-7 5-氯-1H-咪唑[4,5-b... | CAS号68236-03-3 6-氯吡啶并[3,2-B]吡嗪

2,6-二氯-3-硝基吡啶置于氨,铁粉,氯化铵体系中,用 乙醇,水,乙酸乙酯 作为反应溶剂,化学反应 24.0H,反应生成 6-氯-2,3-二氨基吡啶
参考文献:吡啶并[2,3-B]吡嗪-3(4H)-酮类衍生物及其用途
标题:吡啶并[2,3-B]吡嗪-3(4H)-酮类衍生物及其用途
摘要:本发明提供吡啶并[2,3‑b]吡嗪‑3(4H)‑酮类衍生物及其用途,所述吡啶并[2,3‑b]吡嗪‑3(4H)‑酮类衍生物的结构通式为式ⅴ,包括其药学上可接受的盐,溶剂化物,水合物或晶型.本发明提供的化合物是成纤维细胞生长因子受体(Fgfr)的活性配体,研究表明结构ⅴ所示化合物对katoⅲ胃癌细胞(Fgfr2扩增)和huh‑7肝癌细胞(Fgfr4过表达)具有较好的抗增殖活性,作为fgfr抑制剂在制备治疗由fgfr异常激活导致肿瘤相关疾病的药物中应用.结构通式ⅴ如下:

专利信息

专利号:US-11590142-B2
优先权日:2018-03-28
标题 :Oxazolidinone antibiotic compounds and process of preparation
发明人：PEER MOHAMED SHAHUL HAMEED; BHARATHAM NAGAKUMAR; KATAGIHALLIMATH NAINESH; SHARMA SREEVALLI; NANDISHAIAH RADHA; RAMACHANDRAN VASANTHI
权利人:BUGWORKS RES INC
摘要:Compounds of Formula I, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivative thereof and pharmaceutical compositions containing them as the active ingredient which can be used as medicaments are provided. The aforementioned substances can also be used in the manufacture of medicaments for treatment, prevention, or suppression of diseases, and conditions mediated by microbes. Methods for the synthesis and characterization of the aforementioned substances are also provided.