CAS: 26652-12-0; (2S,3R,4S,5S,6R)-2-(4-Hydroxy-2-(Hydroxymethyl)Phenoxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol

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4-hydroxy-2-(hydroxymethyl)phenyl β-D-glucopyranoside 6-benzoate sodium methylate

📜Nigracin; 4-羟基-2-(羟基甲基)苯基 6-苯甲酰 Beta-D-吡喃葡萄糖苷置于barium Hydroxide octahydrate,硫酸体系中,用 水 用作溶剂,化学反应 2.0H,以99%的收率获得柳匍匐次苷
参考文献:Poliothrysoside And Its Derivatives As Novel Insulin Sensitizers Potentially Driving Ampk Activation And Inhibiting Adipogenesis
标题:Poliothrysoside And Its Derivatives As Novel Insulin Sensitizers Potentially Driving Ampk Activation And Inhibiting Adipogenesis
摘要:In Our Efforts To Develop Safe And Active Chemical Entities From Nature,We First Identified Poliothrysoside (1),A Phytoconstituent Isolated From Flacourtia Indica,Possessing Antidiabetic Potential. Subsequently,Fifteen Derivatives (2-16) Were Synthesized To Assess The Activity Profile Of This Class. All The Compounds Were Analyzed For Their Glucose Uptake Potency In Chronic Insulin-Induced Insulin Resistant 3T3-L1 Adipocytes. Interestingly,Compound 2 Exhibited Strong Ability To Increase The Insulin Sensitivity,Primarily Activating The Ampk Signaling Pathway And Also Inhibited The Adipogenesis In 3T3-L1 Adipocytes,In Concentration Dependent Manner. Overall,These Studies Suggest The Potential Of Poliothrysoside And Its Derivatives As Promising Leads For Non-Insulin Dependent Type 2 Diabetes (T2D). (C) 2014 Elsevier Masson Sas. All Rights Reserved.
Doi:10.1016/j.Ejmech.2014.09.015