CAS: 23501-93-1; (3-(Dimethylamino)Phenyl)Methanol

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3-(dimethylamino)benzoic acid methyl ester 3-(methoxycarbonyl)-N,N,N-trimethylbenzenaminium iodide 2-(3-(dimethylamino)benzyl)-1-(N,N-diethylamino)-diazen-1-ium-1,2-diolateO2-(3-(dimethylamino)benzyl)-1-(N,N-diethylamino)-diazen-1-ium-1,2-diolate 3-(dimethylamino)benzoic acid Tris-p-dimethylamino-o-hydroxymethyltriphenylmethan 3-(dimethylamino)benzaldehyde 3-(bromomethyl)-N,N-dimethylaniline 2-iodo-5-(N,N-dimethylamino)benzyl alcohol

📜3-(Methoxycarbonyl)-N,N,N-Trimethylbenzenaminium Iodide置于lithium Aluminium Tetrahydride体系中,化学反应生成3-(二甲氨基)苯甲基醇
参考文献:O2-苄基取代的二氮烯二醇盐中一氧化氮的受控光化学释放
标题:O2-苄基取代的二氮烯二醇盐中一氧化氮的受控光化学释放
摘要:已经启动了对二氮烯二醇 (R2N-N(O)=no-) 潜在光敏保护基团的研究,这里研究了间位给电子基团对 O2-苄基取代的二氮烯二醇 (R2N-N(O) )=noch2Ar) 被报道.母体苄基衍生物 (Ar = Ph) 的光解几乎完全导致不希望的光化学反应-亚硝胺和氧氮烯中间体的形成,如果有的话,二氮烯二醇的光释放很少.我们已经能够使用元取代来调整这些苄基系统的光化学.已显示所需的二氮烯二醇光离型剂随着更强的 Pi 供体间位取代基变得更加坚固.这种效应已经通过用 1H NMR 光谱直接观察光释放的二氮烯二醇和在高和低 Ph 溶液中进行的 No 定量测量得到证实.此外,观测到的 No 释放速率与二氮烯二醇在水溶液中正常热分解的预期速率一致,并且也显示出相同的 Ph 依赖性.
Doi:10.1021/ja026900S

专利信息

专利号:US-7179918-B2
优先权日:2001-06-11
标 题:HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
发明人：CANAN KOCH STACIE S; ALEXANDER THERESE N; BURKE BENJAMIN J; JEWELL TANYA M; KUCERA DAVID J; LINTON MARIA ANGELICA; MITCHELL JR LENNERT J; REICH SIEGFRIED H; SKALITZKY DONALD J; TATLOCK JOHN H; VARNEY MICHAEL D; VIRGIL SCOTT C; WEBBER STEPHEN E; WORLAND STEPHEN T; BARVIAN MARK; BOLTON GARY; BOYER JR FREDERICK EARL; MACHAK JEFFREY J; HOLLER TOD; MURPHY SEAN T; MELNICK MICHAEL; JOSYULA VARA PRASAD
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n nwhere the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:US-7169932-B2
优先权日:2001-06-11
标题:HIV protease inhibitors, compositions containing the same, their pharmaceutical uses, material for their synthesis
发明人：KUCERA DAVID JOHN; SCOTT ROBERT WILLIAM
权利人:PFIZER
摘要:Compounds of the formula: n nwhere the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:US-7094909-B2
优先权日:2001-06-11
标 题 :HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
发明人：KUCERA DAVID JOHN; SCOTT ROBERT WILLIAM
权利人:AGOURON PHARMA
摘要:The present invention concerns processes for preparing compounds of formula (I-H), or a prodrug, pharmaceutically active metabolite, or pharmaceutically active salt or solvate thereof, n nwhich are useful as inhibitors of the HIV protease enzyme.