CAS: 19856-23-6; Sodium 4-Oxopentanoate

专利信息

专利号:US-6846917-B2
优先权日:2001-01-23
标题:Solid- and solution-phase synthesis of heparin and other glycosaminoglycans
发明人：SEEBERGER PETER H; ORGUEIRA HERNAN; SCHELL PETER
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Described is a modular, general synthetic strategy for the preparation in solution and on a solid support of heparin, heparin-like glycosaminoglycans, glycosaminoglycans and non-natural analogs of each of them. Additionally, the modular strategy provides the basis for the preparation of combinatorial libraries and parallel libraries of defined glycosaminoglycan oligosaccharides. The defined glycosaminoglycan structures may be used in high-throughput screening experiments to identify carbohydrate sequences that regulate a host of recognition and signal-transduction processes. The determination of specific sequences involved in receptor binding holds great promise for the development of molecular tools which will allow modulation of processes underlying viral entry, angiogenesis, kidney diseases and diseases of the central nervous system. Notably, the present invention enables the automated synthesis of glycosaminoglycans in much the same fashion that peptides and oligonucleotides are currently assembled.

专利号:WO-2014148928-A1
优先权日:2013-03-21
标 题:Method for incorporating protecting acetal and acetal ester groups, and its application for the protection of hydroxyl function
发明人：MARKIEWICZ WOJCIECH; TOÅš-MARCINIAK AGNIESZKA; CHMIELEWSKI MARCIN
权利人:INST CHEMII BIOORG POLSKIEJ AKADEMII NAUK
摘要:The present invention is the method for incorporation of acetal and acetal ester groups for protection of hydroxyl function. The method is applied in particular in the processes of RNA synthesis. The method can be employed in the synthesis of nucleosides with acetal and acetal ester groups for the protection of hydroxyl functions. The method according to the invention consists of the reaction of an organic compound containing at least one hydroxyl group, soluble in an aprotic solvent, with a compound of the general formula 1, R 1 -S-CH 2 -O-R 2 (1) in the presence of SnCl 4 , in an aprotic solvent. In the second aspect, the present invention is the method of protecting the hydroxyl function, particularly in position 2', in nucleoside derivatives, based on the incorporation of an acetal or acetal ester group.

专利号:US-9249175-B2
优先权日:2008-09-05
标 题 :RNA monomers containing O-acetal levulinyl ester groups and their use in RNA microarrays
发明人：DAMHA MASAD; LACKEY JEREMY; MITRA DEBBIE; WICKENS MARVIN; CERRINA FRANCO; SOMOZA MARK
权利人:DAMHA MASAD; LACKEY JEREMY; MITRA DEBBIE; WICKENS MARVIN; CERRINA FRANCO; AKHTAR SAIMA A; SOMOZA MARK; ROYAL INST FOR THE ADVANCEMENT OF LEARNING MCGILL UNIVERSITY; WISCONSIN ALUMNI RES FOUND
摘要:The present invention is directed to RNA monomers comprising O-acetal levulinyl protecting groups at the 2′ and/or the 5′-hydroxy functionalities of the ribose moiety. Said monomers may be incorporated into oligoribonucleotides or RNA polynucleotides. Furthermore, the invention is directed to methods for the synthesis of said RNA monomers, oligoribonucleotides and RNA polynucleotides, as well as methods for their deprotection and methods for the use of said compounds and compositions comprising said compounds. In particular, such compounds and compositions comprising them are used in methods for light-directed synthesis of RNA microarrays.

专利号:US-11692058-B2
优先权日:2021-02-26
标题:Synthesis of functional polyurethanes and polyesters from biomass-derived monomers
发明人：CHANG HOCHAN; HUBER GEORGE W; DUMESIC JAMES A
权利人:WISCONSIN ALUMNI RES FOUND
摘要:A method of making polyesters and polyurethanes from biomass-derived polyols. The polyol is biomass-derived and has the structure:wherein dashed bonds are single or double bonds and R is selected from the group consisting of —OH and â•?O. Polyurethanes are made by reacting the polyol with a diisocyanate. Polyesters are made by reacting the polyol with a dicarboxylic acid.

专利号:US-2003013862-A1
优先权日:2001-01-23
标 题:Solid- and solution-phase synthesis of heparin and other glycosaminoglycans

专利号:US-2005187381-A1
优先权日:2001-01-23
标题:Solid- and solution-phase synthesis of heparin and other glycosaminoglycans