CAS: 16013-85-7; 2,6-Dichloro-3-Nitropyridine

上下游产品

CAS号2402-78-0 2,6-二氯吡啶 | CAS号120-43-4 N-哌嗪甲酸乙酯 | CAS号1094323-33-7 4-(6-氯-3-硝基-吡啶-... | CAS号61100-30-9 4-(6-吗啉基-3-硝基-2... | CAS号108118-69-0 2,6-二氟-3-胺基吡啶 | CAS号40851-95-4 6-氯-2,3-二氨基吡啶 | CAS号33400-49-6 2-氨基-3-硝基-6-(4-... | CAS号33742-70-0 2-甲氨基-3-硝基-6-氯吡啶 | CAS号73895-39-3 N*2*,N*6*-Dimet... | CAS号40851-91-0 2-甲氧基-3-硝基-6-氯吡啶 | CAS号38533-61-8 2-氯-6-甲氧基-3-硝基吡啶 | CAS号18677-41-3 2,6-二甲氧基-3-硝基吡啶

2,6-二氯吡啶置于硫酸,硝酸体系中,化学反应生成2,6-二氯-3-硝基吡啶
参考文献:优化 4,6-二取代吡啶并[3,2-D]嘧啶作为双重 Mnk/pim 抑制剂抑制白血病细胞生长
标题:优化 4,6-二取代吡啶并[3,2-D]嘧啶作为双重 Mnk/pim 抑制剂抑制白血病细胞生长
摘要:丝裂原激活蛋白激酶相互作用激酶 (Mnk) 和马洛尼鼠白血病病毒激酶 (Pim) 中的前病毒整合是与酪氨酸激酶抑制剂耐药相关的细胞增殖信号通路的下游酶. Mnk 和 Pim 在调节癌蛋白的帽子依赖性翻译方面具有互补作用. Mnk 和 Pim 的双重抑制剂尚未开发出来.我们开发了一种新型 4,6-二取代吡啶并[3,2-D ]嘧啶化合物21O,具有选择性抑制 Mnk 和 Pim 的作用. 21O抑制mnk1和mnk2的ic 50分别为1和7Nm,抑制pim1,Pim2和pim3的ic 50 分别为43,232和774Nm. 21O抑制髓系白血病 K562 和 Molm-13 细胞的生长,Gi 50分别为 2.1 和 1.2 μm. 21O降低p-Eif4E 和p-4Ebp1(mnk 和 Pim 的下游产物)以及帽依赖蛋白 C-Myc,细胞周期蛋白 D1 和 Mcl-1 的水平. 21O抑制
Doi:10.1021/acs.Jmedchem.1C01084

专利信息

专利号:US-9834556-B2
优先权日:2014-03-24
标题 :Process of preparing 3-(3-(4-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-B]pyridin-2-YL)pyridin-2-amine
发明人：BATES CRAIG; CHEN JIAN-XIE; MAO JIANMIN; REED DAVID P
权利人:ARQULE INC
摘要:The present invention is directed to a processes for the synthesis of 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine:

专利号:EP-2084147-B1
优先权日:2006-08-29
标 题:Heterocyclic fxr binding compounds
发明人：KREMOSER CLAUS; DEUSCHLE ULRICH; ABEL ULRICH; SCHULZ ANDREAS
权利人:PHENEX PHARMACEUTICALS AG
摘要:The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists or partial agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.

专利号:US-8389703-B1
优先权日:2004-08-28
标 题 :Ribonucleoside analogs with novel hydrogen bonding patterns
发明人：BENNER STEVEN A; KIM HYO-JOONG
权利人:BENNER STEVEN A; KIM HYO-JOONG
摘要:This invention relates to nucleoside, nucleotide, and oligonucleotide analogs that incorporate non-standard nucleobase analogs, defined to be those that present a pattern of hydrogen bonds to a paired nucleobase analog in a complementary strand that is different from the pattern presented by adenine, guanine, cytosine, and thymine. The invention is specifically concerned with nucleotide analogs that present the donor-donor-acceptor, hydrogen bonding patterns on pyrimidine analogs, and especially those that are analogs of ribonucleotides, including protected ribonucleotides suitable for phosphoramidite-based synthesis of RNA. The heterocycles on these nucleoside analogs are aminopyridones that have electron withdrawing groups attached to the position analogous to the 5-position of the ring in standard pyrimidines, including nitro, cyano, and carboxylic acid derivatives.

专利号:US-2025026766-A1
优先权日:2022-01-12
标题 :Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors
发明人：LI JING; XU WENQING; WANG ZHIWEI
权利人:BEIGENE LTD
摘要:The present invention relates to compounds containing thiazolopyridyl amide structure, the process for their synthesis, as well as the use of such compounds for inhibiting DNA Polymerase Theta (Pol Theta), and in the treatment of various diseases including cancers.

专利号:CN-120463643-A
优先权日:2025-05-27
标题:Synthesis method of 2-cyclopropylamino-3-nitro-6-chloropyridine

专利号:CN-111732536-B
优先权日:2020-08-26
标 题:Synthesis method of aminopyridine compound