CAS: 14464-32-5; 2,5-Dioxopyrrolidin-1-Yl Stearate

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14464-31-4 14464-30-3 69888-86-4

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CAS号6066-82-6 N-羟基琥珀酰亚胺 | CAS号57-11-4 硬脂酸 | CAS号105955-10-0 STEARDA | CAS号111-57-9 硬脂酰胺MEA | CAS号67603-50-3 N-Stearoyl-L-cy... | CAS号54336-64-0 N-(1,3-dihydrox... | CAS号6162-69-2 N-(2-sulfanylet...

📜硬脂酸 以 乙醇 用作溶剂,化学反应 1.0H,反应生成N-羟基琥珀酰亚胺硬酯酸酯
参考文献:脂肪酸接枝的壳聚糖聚合物及其纳米蛋白的合成和表征,用于非病毒基因递送应用.
标题:脂肪酸接枝的壳聚糖聚合物及其纳米蛋白的合成和表征,用于非病毒基因递送应用.
摘要:这项研究的目的是合成和表征脂肪酸接枝的壳聚糖(脂肪酸-G-Cs)聚合物及其纳米胶束,以用作基因传递的载体.Cs使用增加的脂肪酰基链长度的饱和脂肪酸进行疏水改性.碳二亚胺与n-羟基琥珀酰亚胺一起用于将脂肪酸的羧基与cs的胺基偶联.质子核磁共振和傅里叶变换红外光谱用于量化脂肪酰基取代到cs骨架上.使用尺寸排阻高效液相色谱法测定了合成聚合物的分子量分布,发现该分子量在母体cs聚合物的范围内(〜50 Kda).使用pyr作为荧光探针确定聚合物的临界胶束浓度(cmc).发现cmc随着脂肪酰基链长度的增加而降低.两亲脂肪酸-G-Cs聚合物在水性环境中自组装,形成约200 Nm粒径的纳米胶束,并且由于cs分子上游离伯氨基的阳离子性质,其净电荷略微为正.这些高分子纳米胶束分别通过体外溶血和mtt细胞活力测定法表现出优异的血液和细胞相容性,与未修饰的脱乙酰壳多糖和裸露的dna相比,转染效率更高.这些纳米胶束
Doi:10.1021/acs.Bioconjchem.7B00505

专利信息

专利号:US-4315909-A
优先权日:1978-09-25
标题 :Process for the preparation of solid drug formulations
发明人：HUETTENRAUCH REINHARD
权利人:JENAPHARM VEB
摘要:In order to allow for the greatest possible range of variation in the rate of liberation of active agents within an organism and to allow for the use of a wide variety of active agents in solid drug formulations, cellulose graft copolymers are employed as adjuvant. The excellent flow properties and compacting behavior of these cellulose graft copolymers allow for formulation without the need for additional process steps, while variations in the type and proportion of the grafted components allows for the synthesis of adjuvants ideally suited for a specific intended use.

专利号:US-8697888-B2
优先权日:2012-01-06
标题 :Substituted (1-(methylsulfonyl)azetidin-3-yl)(heterocycloalkyl)methanone analogs as antagonists of muscarinic acetylcholine M1 receptors
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; MELANCON BRUCE J; CHEUNG YIU-YIN
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted (1-(methylsulfonyl)azetidin-3-yl)(heterocycloalkyl)methanone analogs, derivatives thereof, and related compounds, which are useful as antagonists of the muscarinic acetylcholine receptor M 1 (mAChR M 1 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-2006084805-A1
优先权日:2004-09-30
标题:Synthesis of thienopyridinone compounds and related intermediates

专利号:WO-03016469-A2
优先权日:2001-08-17
标题:Chemo-enzymatic synthesis of sialylated oligosaccharides

专利号:US-9012445-B2
优先权日:2012-01-12
标题 :Substituted 4-(1H-pyrazol-4-yl)benzyl analogues as positive allosteric modulators of mAChR M1 receptors
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; MELANCON BRUCE J; POSLUSNEY MICHAEL S; TARR JAMES C
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted 4-(1H-pyrazol-4-yl)benzyl analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 1 (mAChR M 1 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-9751877-B2
优先权日:2012-09-21
标题 :Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; PATEL NANDINI CHATURBHAI; STIFF CORY MICHAEL; TRAN TUAN PHONG; KAUFFMAN GREGORY WAYNE; STEPAN ANTONIA FRIEDERIKE; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.