CAS: 1322062-57-6; Moxifloxacin Decarboxy Analog
- 英文名称Moxifloxacin Decarboxy Analog
- 中文名称莫西沙星去羧基类似物
- IUPAC名称7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-8-methoxyquinolin-4-one
- CAS编号1322062-57-6
- MFCD编号:MFCD34469893
- EINECS号:806-080-0
- FDA UNII编号:689HB56KKU
- 分子式:C20H24FN3O2分子量:357.42
- 产品CID: 488134
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
moxifloxacin合成工艺路线路线简述
📜莫西沙星置于sodium Cyanide体系中,用 二甲基亚砜 用作溶剂,化学反应 17.0H,以99%的收率获得莫西沙星去羧基类似物
参考文献:Synthesis And Evaluation Of 1-Cyclopropyl-2-Thioalkyl-8-Methoxy Fluoroquinolones
标题:Synthesis And Evaluation Of 1-Cyclopropyl-2-Thioalkyl-8-Methoxy Fluoroquinolones
摘要:Novel Fluoroquinolone Derivatives Substituted With A 2-Thioalkyl Moiety,With And Without A Concomitant 3-Carboxylate Group,Were Synthesized To Evaluate The Effect Of C-2 Thioalkyl Substituents On Gyrase Binding And Inhibition. The Presence Of A 2-Thioalkyl Group Universally Decreased Activity As Compared To Parent Fluoroquinolones. However,With Derivatives Of Moxifloxacin The Presence Of Either A 2-Thioalkyl Group Or A 3-Carboxylate Moiety Increased Activity Over The 2,3-Unsubstituted Derivative. Energy Minimization Of Structures Provides An Explanation For Relative Activities Of Fluoroquinolones Having A C-2 Thio Moiety. (C) 2011 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2011.05.112
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- 2905110000-甲醇
2921211000-乙二胺
2933310010-吡啶
2908199090-其他酚的卤化衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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合成参考文献
参考文献:10.1016/j.bmcl.2011.05.112
摘要:Marks KR, Malik M, Mustaev A, Hiasa H, Drlica K, Kerns RJ. Synthesis and evaluation of 1-cyclopropyl-2-thioalkyl-8-methoxy fluoroquinolones. Bioorganic & Medicinal Chemistry Letters. 2011 Aug;21(15):4585–8. doi: 10.1016/j.bmcl.2011.05.112.
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