CAS: 945863-21-8; N-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Picolinamide

英文名称N-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Picolinamide
中文名称N-甲基-5-(4,4,5,5-四甲基-1,3,2-二氧杂硼杂环戊烷-2-基)吡啶酰胺
IUPAC名称N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinamide
其它别名2-(N-甲氨基羰基)-5-吡啶硼酸频那醇酯; 7 2-(N-Methylaminecarbonyl)-5-Pyridineboronic Acid Pincol
CAS编号945863-21-8
MFCD编号:MFCD08458483
分子式:C13H19BN2O3
分子量:262.11
产品CID: 1997434
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: LUMBLRWRRONQMO-UHFFFAOYSA-N
InChI=1S/C13H19BN2O3/c1-12(2)13(3,4)19-14(18-12)9-6-7-10(16-8-9)11(17)15-5/h6-8H,1-5H3,(H,15,17)…
计算化学: 氢键受体数4.0氢键供体数1.0可旋转键数2.0

相似化合物

1217340-94-7 1257553-74-4 1006876-27-2

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

上下游产品

5-bromo-2-(N-methylamin°Carbonyl)pyridine bis(pinacol)diborane 5-{2-fluoro-4-[3-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-a]pyrimidin-6-yl]phenyl}-N-methylpyridine-2-carboxamide N-methyl-5-{4-[7-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-b][1,2,4]triazin-2-yl]phenyl}pyridine-2-carboxamide 5-3-fluoro-4-[(5S)-2-(cis-4-hydroxycyclohexyl)-1-oxo-2,7-diazaspiro[4.5]dec-7-yl]phenyl-N-methylpyridine-2-carboxamide

合成工艺路线路线简述

73183-34-3 + 845305-87-5 = 945863-21-8
反应条件:1.1 Reagents: Potassium Acetate Catalysts: Dichloro[1,1′-Bis(Diphenylphosphino)Ferrocene]Palladium(Ii) Dichloromethane Addu... Solvents: 1,4-Dioxane; Rt -> 80 °C; 12 H,80 °C
标题:Preparation Of Disubstituted Imidazo[4,5-B]Pyridine And Disubstituted [1,2,3]Triazolo[4,5-B]Pyridine Compounds As C-Met Protein Kinases Inhibitors For Treatment Of Kinase-Mediated Diseases
参考文献:World Intellectual Property Organization]

73183-34-3 + 845305-87-5 = 945863-21-8
反应条件:1.1 Reagents: Potassium Acetate Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: Dimethylformamide; 2 H,150 °C
标题:2-Aminothiazole Compound Useful In Treatment Of Cancer And Its Preparation
参考文献:China]

73183-34-3 + 845305-87-5 = 945863-21-8
反应条件:1.1 Reagents: Potassium Acetate Catalysts: Dichloro[1,1′-Bis(Diphenylphosphino)Ferrocene]Palladium(Ii) Dichloromethane Addu... Solvents: 1,4-Dioxane; 1 H,110 °C
标题:Preparation Of Thiazolopyridinylacetamide Derivatives And Analogs For Use As Pi3K And Mtor Kinase Inhibitors
参考文献:World Intellectual Property Organization]

= 945863-21-8 [标题:Reaction Conditions
标题:Preparation Of Pyrazolo[3,4-C]Quinoline Compounds As Phosphatidylinositol 3 Kinase Inhibitors For Therapeutic Applications
参考文献:World Intellectual Property Organization]

73183-34-3 + 845305-87-5 = 945863-21-8
反应条件:1.1 Reagents: Potassium Acetate Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: 1,4-Dioxane; 2 H,110 °C
标题:Preparation Of Triazolopyrimidine Compounds Useful In The Treatment Of Diseases Or Disorders Mediated By Eed And/or Prc2
参考文献:United States]

73183-34-3 + 845305-87-5 = 945863-21-8
反应条件:1.1 Reagents: Potassium Acetate Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: 1,4-Dioxane; 2 H,90 °C
标题:1H-Imidazo[4,5-C]Quinolinone Compounds As Protein Kinase Inhibitors And Their Preparation And Use In The Treatment Of Proliferative Diseases
参考文献:World Intellectual Property Organization]

= 945863-21-8 [标题:Reaction Conditions
标题:Preparation Of Tetrahydroisoquinoline Derivatives For Use As Coagulation Factor Xia Inhibitors
参考文献:World Intellectual Property Organization]

73183-34-3 + 845305-87-5 = 945863-21-8 + 1217340-94-7
反应条件:1.1 Reagents: Potassium Acetate Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: 1,4-Dioxane; 2 H,110 °C
标题:Imidazopyrimidine Compounds Useful For The Treatment Of Cancer And Their Preparation
参考文献:World Intellectual Property Organization

N-甲基-5-溴吡啶甲酰胺,联硼酸频那醇酯置于1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 Potassium Acetate体系中,用 1,4-二氧六环作为反应溶剂,化学反应 1.0H,反应生成 2-(N-甲基氨基羰基)吡啶-5-硼酸频那醇酯
参考文献: Pi3K/m Tor Inhibitors[fr] Inhibiteurs De Pi3K/m Tor
标题: Pi3K/m Tor Inhibitors[fr] Inhibiteurs De Pi3K/m Tor