CAS: 89015-27-0; Isopropyl (R)-2-Hydroxy-2-Phenylacetate

该化合物是一种有机化合物,其特征是其酯功能组和一个助其立体化学的手艺中心.该化合物的特征是连接乙酸细胞的苯环,该物质组有-氢氧和异丙基酯.该物质的存在增强了其在极溶液中的溶解性,而苯环则具有疏水特性.(R)配置表明在阳性中心周围原子的具体三维安排,可影响其生物活动和相互作用.该化合物可被用于各种用途,包括制药和农用化学品,因为它具有潜在的再活动性和作为有机合成的构件块的能力.其特性,如熔点,沸点和溶解性,可因环境条件和相关化合物中存在其他功能组而有所变化.

结构式图片

相似化合物

4118-51-8 4358-87-6 20698-91-3

物理性质

MSDS等安全信息

上下游产品

isopropyl benzoylformate (R)-Mandelic Acid isopropyl alcohol triphenylbismuthane1-Methylethyl (R)-2-Acryloyloxy-2-phenylacetate (R)-isopropoxycarbonylbenzyl 2-benzamid°Cinnamate isopropyl (R)-(chloroformyloxy)phenylacetate phenylacetateisopropyl (R)-(2'R,5'R)-2',5'-bis(2''-naphthylethynyl)pyrrolidinylcarbonyloxyphenylacetate

合成工艺路线路线简述

  • 1074-12-0 = 89015-27-0
    反应条件:1.1 Catalysts: Copper(Ii) Triflate,(S,S)-2,2′-Isopropylidenebis[4-Phenyl-2-Oxazoline] Solvents: Dichloromethane; 3 H,Rt1.2 Solvents: 1,2-Dichloroethane; 24 H,Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; Rt
    标题:Asymmetric Intramolecular Cannizzaro Reaction Of Anhydrous Phenylglyoxal
    作者:Ishihara,Kazuaki; Yano,Takayuki; Fushimi,Makoto
    参考文献:Journal Of Fluorine Chemistry 日期:2008 卷标:129(10) 页码:994-997]

    264882-04-4 = 89015-27-0
    反应条件:1.1 Catalysts: Copper Sulfate,Sodium Tetrakis[3,5-Bis(Trifluoromethyl)Phenyl]Borate,(4S,4′s)-2,2′-[(1S)-2,2′,3,3′-Tetrahydro-1,1′-Spirobi[1H-Indene]-7,7′-Diyl]Bis[4... Solvents: Chloroform; 4 H,Rt1.2 Reagents: Water; Rt -> 40 °C; 15 Min,40 °C
    标题:Catalytic Asymmetric Reaction With Water: Enantioselective Synthesis Of α-Hydroxyesters By A Copper-Carbenoid O-H Insertion Reaction
    作者:Zhu,Shou-Fei; Chen,Chao; Cai,Yan; Zhou,Qi-Lin
    参考文献:Angewandte Chemie 日期:2008 卷标:47(5) 页码:932-934]

    1074-12-0 = 89015-27-0
    反应条件:1.1 Catalysts: Copper(Ii) Triflate,(S,S)-2,2′-Isopropylidenebis[4-Phenyl-2-Oxazoline]1.2 Reagents: 1,2-Dichloroethane1.3 -1.4 Reagents: Hydrochloric Acid Solvents: Water1.5 Solvents: Dichloromethane
    标题:Efficient Lewis Acid Catalyzed Intramolecular Cannizzaro Reaction
    作者:Russell,Albert E.; Miller,Steven P.; Morken,James P.
    参考文献:Journal Of Organic Chemistry 日期:2000 卷标:65(24) 页码:8381-8383]

    6818-08-2 = 89015-27-0 + 53439-96-6
    反应条件:1.1 Solvents: Diethyl Ether,Water; 17 H,Ph 8,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 4
    标题:Synthesis Of Chiral α-Aryl-α-Hydroxyacetic Acids: Substituent Effects In Pig Liver Acetone Powder (Plap) Induced Enantioselective Hydrolysis
    作者:Basavaiah,Deevi; Krishna,Peddinti Rama
    参考文献:Tetrahedron 日期:1995 卷标:51(8) 页码:2403-16]

    31197-66-7 = 89015-27-0 + 53439-96-6
    反应条件:1.1 Catalysts: Dibutylmagnesium,Dinaphtho[2,1-D:1′,2′-F][1,3,2]Dioxaphosphepin,4-Hydroxy-2,6-Di-9-Phenanthrenyl... Solvents: Mesitylene,Toluene; 10 Min,Rt1.2 Reagents: Catecholborane; 24 H,Rt1.3 Reagents: Ammonium Chloride Solvents: Water; Rt
    标题:Enantio- And Chemoselective Bronsted-Acid/mg(Nbu)2 Catalysed Reduction Of α-Keto Esters With Catecholborane
    作者:Enders,Dieter; Stoeckel,Bianca A.; Rembiak,Andreas
    参考文献:Chemical Communications (Cambridge 日期:2014 卷标:50(34) 页码:4489-4491]

    4118-51-8 = 89015-27-0 + 85806-02-6
    反应条件:1.1 Catalysts: Scandium Triflate,1799512-71-2 Solvents: Tetrahydrofuran; 30 Min,35 °C; 35 °C -> 0 °C1.2 48 H,0 °C
    标题:Kinetic Resolution Of Racemic Mandelic Acid Esters By N,N'-Dioxide-Scandium-Complex-Catalyzed Enantiomer-Selective Acylation
    作者:Zhang,Yuheng; Liu,Xiaohua; Zhou,Lin; Wu,Wangbin; Huang,Tianyu; Et Al
    参考文献:Chemistry - A European Journal 日期:2014 卷标:20(48) 页码:15884-15890]

    4118-51-8 = 89015-27-0 + 31197-66-7
    反应条件:1.1 Catalysts: Cobalt Diacetate,2,2′-[(1S)-[1,1′-Binaphthalene]-2,2′-Diylbis[(E)-Nitrilomethylidyne]]Bis[phenol] Solvents: Toluene; 10 Min,Rt1.2 Catalysts: Tempo; 5 Min,Rt1.3 Reagents: Oxygen; 9 H,90 °C
    标题:Chiral Cobalt-Catalyzed Enantioselective Aerobic Oxidation Of α-Hydroxy Esters
    作者:Alamsetti,Santosh Kumar; Sekar,Govindasamy
    参考文献:Chemical Communications (Cambridge 日期:2010 卷标:46(38) 页码:7235-7237]

    31197-66-7 = 89015-27-0
    反应条件:1.1 Solvents: Water; 2 H,Ph 7,30 °C
    标题:Asymmetric Reduction Of Ketones By Employing Rhodotorula Sp. As2.2241 And Synthesis Of The β-Blocker (R)-Nifenalol
    作者:Yang,Wei; Xu,Jian-He; Xie,Yan; Xu,Yi; Zhao,Gang; Et Al
    参考文献:Tetrahedron: Asymmetry 日期:2006 卷标:17(12) 页码:1769-1774]

    1075-06-5 = 89015-27-0
    反应条件:1.1 Catalysts: Iron(2+),Bis(Acetonitrile)Bis[1,3-Dihydro-1-[5-(Trifluoromethyl)-2-Pyridinyl-Kn... Solvents: Dichloromethane; 16 H,Rt
    标题:Chiral-At-Iron Catalyst: Expanding The Chemical Space For Asymmetric Earth-Abundant Metal Catalysis
    作者:Hong,Yubiao; Jarrige,Lucie; Harms,Klaus; Meggers,Eric
    参考文献:Journal Of The American Chemical Society 日期:2019 卷标:141(11) 页码:4569-4572]

    31197-66-7 = 89015-27-0
    反应条件:1.1 Reagents: (R)-Alpine Borane
    标题:Enantioselective Reduction Of Ketones
    作者:Itsuno,Shinichi
    参考文献:Organic Reactions (Hoboken 日期:1998 卷标:52]

    = 89015-27-0
    反应条件:1.1 Reagents: Sodium Formate Catalysts: [n-[(1S,2S)-2-(Amino-Kn)-1,2-Diphenylethyl]-4-Methylbenzenesulfonamidato-Kn]Chlo... Solvents: Methanol; 5 H,40 °C
    标题:Dual Pathway For The Asymmetric Transfer Hydrogenation Of α-Ketoimides To Chiral α-Hydroxy Imides Or Chiral α-Hydroxy Esters
    作者:Zhao,Qiankun; Zhao,Yuxi; Liao,Hang; Cheng,Tanyu; Liu,Guohua
    参考文献:Chemcatchem 日期:2016 卷标:8(2) 页码:412-416]

    31197-66-7 = 89015-27-0
    反应条件:1.1 Reagents: (R)-Alpine Borane
    标题:Selective Reductions. 37. Asymmetric Reduction Of Prochiral Ketones With B-(3-Pinanyl)-9-Borabicyclo[3.3.1]Nonane
    作者:Brown,Herbert C.; Pai,G. Ganesh
    参考文献:Journal Of Organic Chemistry 日期:1985 卷标:50(9) 页码:1384-94]

    4118-51-8 = 89015-27-0 + 31197-66-7
    反应条件:1.1 Reagents: Oxygen Catalysts: (Oc-6-53)-[n-[[3-(1,1-Dimethylethyl)-2-(Hydroxy-Ko)-5-[(1H-1,2,3-Triazol-5-Ylmet... (Polystyrene-Supported) Solvents: Chloroform; 30 H,Rt
    标题:Asymmetric Aerobic Oxidation Of α-Hydroxy Acid Derivatives Catalyzed By Reusable,Polystyrene-Supported Chiral N-Salicylidene Oxidovanadium Tert-Leucinates
    作者:Salunke,Santosh B.; Babu,N. Seshu; Chen,Chien-Tien
    参考文献:Advanced Synthesis & Catalysis 日期:2011 卷标:353(8) 页码:1234-1240]

    4118-51-8 = 89015-27-0 + 31197-66-7
    反应条件:1.1 Reagents: Oxygen Catalysts: (Oc-6-53)-[n-[[3,5-Bis(1,1-Dimethylethyl)-2-(Hydroxy-Ko)Phenyl]Methylene]-3-Meth... Solvents: Toluene; 19 H,Rt1.2 Reagents: Water
    标题:Chiral N-Salicylidene Vanadyl Carboxylate-Catalyzed Enantioselective Aerobic Oxidation Of α-Hydroxy Esters And Amides
    作者:Weng,Shiue-Shien; Shen,Mei-Wen; Kao,Jun-Qi; Munot,Yogesh S.; Chen,Chien-Tien
    参考文献:Proceedings Of The National Academy Of Sciences Of The United States Of America 日期:2006 卷标:103(10) 页码:3522-3527
📜D-扁桃酸,异丙醇置于对甲苯磺酸体系中,用 苯 作为反应溶剂,化学反应 7.0H,以87%的收率获得产物普瑞巴林杂质19
参考文献:2-取代的1 H Indole-3-Ethanamines(= Tryptamines)的c-(烷氧羰基)甲亚胺的非对映选择性螺环化:基础研究.第五次有关吲哚,吲哚肾上腺素和吲哚啉的交流†
标题:2-取代的1 H Indole-3-Ethanamines(= Tryptamines)的c-(烷氧羰基)甲亚胺的非对映选择性螺环化:基础研究.第五次有关吲哚,吲哚肾上腺素和吲哚啉的交流†
摘要:ç-型的(烷氧基羰基)formimines 15-18是从2-取代的色胺衍生的2,9,10,和11和用甲苯磺酰氯转化为类型三环3-Spiroindoles 19-22(方案3).研究了同手性烷氧基部分ad对该反应的立体化学结果的影响.以(-)-8-(苯基薄荷基-3-基)氧基(b)为纯手性助剂,观测到优异的非对映选择性.三轮车4,(2'R,3 S)-19B和(2'通过x射线分析确定s,3 R)20C,通过noe和cd研究以及通过化学相关性确定其他化合物的结构.讨论了解释螺环化的空间过程的可能性.
DOI:10.1002/hlca.19900730224

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合成方法参考DOI号:10.1002/hlca.19900730224
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