CAS: 83-74-9; Ibogaine

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CAS号510-22-5 伏康京碱 | CAS号113950-91-7 12-methoxy-20,2... | CAS号3885-19-6 12-Methoxy-16-m...

📜12-Methoxy-Ibogamin-19-One置于四氢呋喃,Lithium Aluminium Tetrahydride体系中,化学反应生成 伊博格碱
参考文献:Us2877229
标题:Us2877229

专利信息

专利号:US-11912647-B2
优先权日:2020-05-22
标 题:Diversity-oriented synthesis of N,N,O-trisubstituted hydroxylamines from alcohols and amines by N—O bond formation
发明人：CRICH DAVID; HETTIKANKANAMALAGE ASIRI; HILL JARVIS
权利人:UNIV GEORGIA
摘要:In one aspect, the disclosure relates to a method for the direct synthesis of complex N,N,O-trisubstituted hydroxylamines by N—O bond formation. In another aspect, the method can successfully be employed using a wide variety of commercially available alcohols and secondary amines and enables the construction of large fragment-based libraries of trisubstituted hydroxylamines for drug discovery purposes. Also disclosed are N,N,O-trisubstituted hydroxylamines having low basicity, high stability at ambient temperatures, and an inherent lack of reactivity towards acetylating and sulfonylating enzymes that confer mutagenicity on less-substituted hydroxylamines.

专利号:US-12331051-B2
优先权日:2021-09-20
标 题 :LSD derivatives, synthesis and method for treatment of diseases and disorders
发明人：SHESHBARADARAN HOOSHMAND; RUDGE SCOTT; GHAFFARI ABDI; SODERMAN STEFAN; DUSPARA PETAR
权利人:BETTERLIFE PHARMA INC
摘要:LSD derivative compounds and polymorphs thereof, methods for their synthesis, compositions and treatment of diseases and disorders are described herein, the compounds having the structure of Formula I: n nincluding pharmaceutically acceptable salts, hydrates, solvates, tautomers, enantiomers, diastereomers, racemates, polymorphs or combinations thereof; wherein: R 1 to R 14 are each independently selected from H, or a substituted or unsubstituted hydrocarbon group and X is selected from a halo group.

专利号:EP-3137618-A1
优先权日:2014-04-29
标 题 :Improved methods for making and using polynucleotide sequences in the synthesis of alkaloid compounds

专利号:US-9751877-B2
优先权日:2012-09-21
标题 :Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; PATEL NANDINI CHATURBHAI; STIFF CORY MICHAEL; TRAN TUAN PHONG; KAUFFMAN GREGORY WAYNE; STEPAN ANTONIA FRIEDERIKE; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-7872013-B2
优先权日:2006-08-16
标 题 :Preparation and utility of opioid analgesics
发明人：GANT THOMAS G; SARSHAR SEPEHR
权利人:AUSPEX PHARMACEUTICALS INC
摘要:The present disclosure is directed to modulators of opiate- and/or NMDA receptors and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the use of such compounds for the treatment and/or management of pain, anxiety, neurodegeneration, drug dependence, coughing, muscular tension, and/or glaucoma and any other condition in which it is beneficial to modulate an opiate- and/or NMDA receptor.

专利号:US-9403837-B2
优先权日:2011-12-08
标 题 :Stereoselective total synthesis of noribogaine
发明人：MORIARTY ROBERT M; MASH DEBORAH C
权利人:DEMERX INC
摘要:This invention relates generally to methods for synthesizing the non-addictive alkaloid noribogaine.