CAS: 653-21-4; 2-(Perfluorophenyl)Acetic Acid

该化合物是一种氟芳烃化合物,其特点是,苯环附有5个氟原子,以及一个乙酸功能组;该化合物因其氟化物替代成分而具有高电子性,显著影响其化学反应和物理特性;该化合物一般具有高度稳定性和低挥发性,在各种化学应用中有用,包括作为有机合成的试剂和药品的开发;多种氟原子的存在,会增强其脂性,并可能影响其溶液性;此外,该化合物可能展示与生物系统的独特互动,而生物系统可能对药用化学感兴趣;在处理该物质时,安全因素十分重要,因为氟化化合物可能对环境和健康造成危害.

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CAS号771-56-2 2,3,4,5,6-五氟甲苯 | CAS号344-04-7 溴五氟苯 | CAS号653-37-2 五氟苯甲醛 | CAS号827-15-6 五氟碘苯 | CAS号440-60-8 五氟苄醇 | CAS号653-35-0 2,3,4,5,6-五氟苄基氯 | CAS号1765-40-8 2,3,4,5,6-五氟溴苄 | CAS号653-30-5 2,3,4,5,6-五氟苯基乙腈 | CAS号124-38-9 二氧化碳 | CAS号653-31-6 2-(五氟苯基)乙醇 | CAS号653-20-3 2-(2,3,4,5,6-pe... | CAS号832-72-4 Benzeneacetyl c... | CAS号853-74-7 1,2,3,4,5-penta...

合成工艺路线路线简述

    📜2,3,4,5,6-五氟甲苯置于硫酸,溴,溶剂黄146体系中,用 乙醇 作为反应溶剂,化学反应生成 5-氟苯乙酸
    参考文献:173.芳族多氟化合物.第八部分 五氟苯甲醛及相关的五氟苯基酮和羧酸
    标题:173.芳族多氟化合物.第八部分 五氟苯甲醛及相关的五氟苯基酮和羧酸
    摘要:
    DOI:10.1039/jr9610000808

    海关参考信息

    专利信息


    专利号:US-5214218-A
    优先权日:1992-05-04
    标题 :One step synthesis of methyl t-butyl ether from t-butanol using haloacid-modified clay catalysts
    发明人:KNIFTON JOHN F
    权利人:TEXACO CHEMICAL
    摘要:A method is disclosed wherein t-butanol is reacted with methanol in a reaction zone in one step to provide methyl tert-butyl ether and the improvement of accomplishing the reaction which comprises: n a. Using a catalyst comprising a montmorillonite clay treated with a haloacid; n b. continuously contacting said t-butanol and methanol in a molar amount of about 0.1 to 10 moles of methanol per mole of t-butanol with said catalyst at a temperature of about 20° C. to about 250° C. and a pressure of about atmospheric to about 1000 psig to obtain the methyl tert-butyl ether product.

    专利号:US-6531470-B1
    优先权日:1998-01-23
    标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:US-12180188-B2
    优先权日:2020-05-19
    标题:Antifibrotic compounds and related methods
    发明人:STEFANOVIC BRANKO; NEFZI ADEL
    权利人:UNIV FLORIDA STATE RES FOUND; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
    摘要:This discloses that compounds of Formula 1 have antifibrotic properties. In particular, this discloses a pharmaceutical composition including one or more compounds of Formula 1 and methods of using compounds of Formula 1 in fibrosis treatment and inhibiting type 1 collagen synthesis.

    专利号:US-6562844-B2
    优先权日:1998-01-23
    标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:US-9217012-B2
    优先权日:2009-04-08
    标题 :Inhibitors of protein tyrosine phosphatases
    发明人:ZHANG ZHONG-YIN; ZHANG SHENG
    权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
    摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

    专利号:US-7002020-B1
    优先权日:1998-01-23
    标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: S L De Wall, Et Al. Synthetic Receptors As Models For Alkali Metal Cation-Pi Binding Sites In Proteins. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6271-6.
    [参考文献]: Sebastian Demkowicz, Et Al. Synthesis And Biological Evaluation Of Fluorinated 3-Phenylcoumarin-7-O-Sulfamate Derivatives As Steroid Sulfatase Inhibitors. Chem Biol Drug Des. 2016 Feb;87(2):233-8.

    合成参考文献


    参考文献:10.1055/s-0033-1340194
    摘要:Weaver J. Hydrodefluorination of Perfluoroarenes Meets Visible Light Photocatalysis. Synlett. 2014 May 23;25(14):1946–52. doi: 10.1055/s-0033-1340194.
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