CAS: 63478-76-2; 6-Heptyn-1-Ol

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四氢吡喃置于3,4-二氢-2H-吡喃,Potassium Carbonate,Zinc Dibromide体系中,用 甲醇 作为反应溶剂,化学反应生成 6-庚炔醇
参考文献:Total Synthesis Of Patulolide C And Its Homo-,Nor,And Iso Analogs
标题:Total Synthesis Of Patulolide C And Its Homo-,Nor,And Iso Analogs
摘要:The Stereospecific Total Synthesis Of The Naturally occurring Macrolide Patulolide C 19Eb As Well As Its Iso,Nor,And Homo Analogs Is Described By Applying The Photoinduced Rearrangement Of Enantiomerically Pure Epoxy Diazomethyl Ketones 14 To Gamma-Hydroxy Alpha,Beta-Unsaturated Esters 15 As The Key Step. The Required Epoxy Diazomethyl Ketones 14 Are Obtained By A Sharpless Epoxidation Of An Appropriate Allylic Alcohol,Followed By Ruthenium Tetraoxide Oxidation To An Oxiranecarboxylic Acid,Conversion Into A Mixed Anhydride,And Treatment With Diazomethane. Macrolide 19Zb,Which Is A Geometrical Isomer Of 19Eb,Turned Out To Be A Diastereomer Of Natural Macrolide Isopatulolide C,Which Implies The 4R,11R Configuration For This Natural Material. X-Ray Diffraction Analyses Of 19Ea And 19Eb Show That There Is A Considerable Difference In Spatial Arrangement; Particularly,The Different Torsion Angles Between The Carbonyl And Olefinic Bonds Are Note Worthy. The Conformational Behavior Of These Macrolides Is Also Deduced From The NMR And Uv Spectra.
DOI:10.1021/jo00077A047

专利信息

专利号:US-7183432-B2
优先权日:2004-06-04
标题 :Synthesis of ynamides
发明人：KRAUS GEORGE A; BAE JAEHOON
权利人:UNIV IOWA STATE RES FOUND INC
摘要:A method of synthesizing diacetylenic amides is described. The key steps of the invention include the reaction of an aldehyde with the monoanion of a diacetylene and the reductive removal of a propargylic alcohol. The invention offers the first known method of synthesizing diacetylenic amides that are naturally isolated from Echinacea through a direct and flexible route.

专利号:US-2005272954-A1
优先权日:2004-06-04
标题 :Synthesis of ynamides

专利号:US-2024208898-A1
优先权日:2021-03-25
标 题 :Enamine n-oxides: synthesis and application to hypoxia-responsive prodrugs and imaging agents
发明人：KIM JUSTIN; KANG DAHYE; CHEUNG SHELDON T
权利人:DANA FARBER CANCER INST INC
摘要:Disclosed are compounds and pharmaceutically acceptable salts and stereoisomers thereof that are suitable for diagnosis and the treatment of diseases and disorders characterized by, associate with or which exhibit tissue hypoxia, such as, for example, solid tumors. Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds.

专利号:US-11001783-B2
优先权日:2016-08-16
标题:Synthesis and use of ω-hydroxylated polyunsaturated fatty acids
发明人：ZHANG GUODONG; HAMMOCK BRUCE; HWANG SUNG HEE; WANG WEICANG
权利人:UNIV CALIFORNIA; UNIV MASSACHUSETTS
摘要:The present invention provides a synthetic chemical method for preparing ω-hydroxylated polyunsaturated fatty acids (PUFAs) including 20-hydroxyeicosatetraenoic acid (20-HETE), 20-hydroxyeicosapentaenoic acid (20-HEPE), and 22-hydroxydocosahexaenoic acid (22-HDoHE) and a method of use thereof for treating cancer and macular degeneration.

专利号:US-9896479-B2
优先权日:2012-05-16
标 题 :Functionalized naphthalene fluorophores
发明人：BRUMMOND KAY M; KOCSIS LAURA S; BENEDETTI ERICA
权利人:BRUMMOND KAY M; KAY M BRUMMOND
摘要:Methods for the synthesis and use of functionalized, substituted naphthalenes are described. The functionalized, substituted naphthalenes display useful properties including liquid crystals and fluorescence properties, such as solvatochromatic fluorescence, with high quantum yields, Stoke's shift, and show emission maxima that are significantly red-shifted.

专利号:US-2019270950-A1
优先权日:2016-08-16
标 题:Synthesis and use of omega-hydroxylated polyunsaturated fatty acids